Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention

To evaluate the efficacy and safety of different doses of tiloxime hydrochloride tablets in the treatment of silicosis using placebo as control.

This study intends to conduct a pharmacokinetic study on oral administration of Tiloxime Hydrochloride Tablets developed by the Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, in healthy Chinese male volunteers, with the aim of providing accurate in vivo metabolic parameters and experimental basis for the design of clinical dosing regimen and dosage determination of Tiloxime Hydrochloride Tablets.

Healthy male volunteers were selected, and different doses of the drug were given to the subjects using a dose-escalation scheme, starting from a safe initial dose, to observe the body's tolerance to Tiloxime Hydrochloride Tablets, so as to provide a safe dosage range for the formulation of the dosing regimen for the Phase II clinical trial of this product.