Delving into the Latest Updates on Brise Pharmaceuticals Co., Ltd. with Synapse

Overview

Tags

Nervous System Diseases

Other Diseases

Cardiovascular Diseases

Small molecule drug

Monoclonal antibody

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Nervous System Diseases	9

Top 5 Drug Type	Count

Unknown	5
Small molecule drug	4
Monoclonal antibody	1

Top 5 Target	Count

CGRP(Calcitonin gene-related peptide)	1
TRPM3(transient receptor potential cation channel subfamily M member 3)	1
TrkA(Nerve growth factor receptor Trk-A)	1

主要目的：1.在健康成年试验参与者中评估多次口服CYP3A4诱导剂利福平胶囊对BR005-036C片药代动力学特征的影响；2.在健康成年试验参与者中评估多次口服CYP3A4/P-gp抑制剂伊曲康唑胶囊对BR005-036C片PK特征的影响； 3. 在健康成年试验参与者中评估多次口服BR005-036C片对CYP3A底物咪达唑仑PK特征的影响。次要目的：在健康成年试验参与者中评估BR005-036C片分别与利福平、伊曲康唑、咪达唑仑合并用药的安全性和耐受性

[Translation]

Primary Objectives: 1. To evaluate the effect of multiple oral administrations of the CYP3A4 inducer rifampin capsules on the pharmacokinetic characteristics of BR005-036C tablets in healthy adult participants; 2. To evaluate the effect of multiple oral administrations of the CYP3A4/P-gp inhibitor itraconazole capsules on the pharmacokinetic characteristics of BR005-036C tablets in healthy adult participants; 3. To evaluate the effect of multiple oral administrations of BR005-036C tablets on the pharmacokinetic characteristics of the CYP3A substrate midazolam in healthy adult participants. Secondary Objectives: To evaluate the safety and tolerability of BR005-036C tablets in combination with rifampin, itraconazole, and midazolam in healthy adult participants.

Start Date05 Sep 2026

Sponsor / Collaborator

Brise Pharmaceuticals Co., Ltd.

100 Clinical Results associated with Brise Pharmaceuticals Co., Ltd.

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0 Patents (Medical) associated with Brise Pharmaceuticals Co., Ltd.

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100 Deals associated with Brise Pharmaceuticals Co., Ltd.

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100 Translational Medicine associated with Brise Pharmaceuticals Co., Ltd.

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Pipeline

Pipeline Snapshot as of 03 Nov 2026

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

6

2

Preclinical

Phase 1

1

Phase 3

Other

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

BR005-036C ( CGRP )	Acute migraine More	Phase 1
Recombinant humanized anti-TrkA monoclonal antibody(Brise Pharmaceutical) ( TrkA )	Low Back Pain More	Phase 1
BR008	Neuralgia More	Preclinical
BR009	Migraine Disorders More	Preclinical
WO2025247396 Patent Mining	Arrhythmias, Cardiac More	Discovery