Zhuhai Tongyuan Pharmaceutical Co. Ltd.

Main study purpose: Using Oseltamivir Phosphate Capsules (Specification: 75 mg, calculated as oseltamivir) developed by Zhuhai Tongyuan Pharmaceutical Co., Ltd. as the test preparation (T), and Oseltamivir Phosphate Capsules (Trade name: Tamiflu®, Specification: 75 mg, calculated as oseltamivir) produced by Delpharm Milano S.r.l., Italy and packaged by Shanghai Roche Pharmaceuticals Co., Ltd. as the reference preparation (R), the pharmacokinetic parameters of the test preparation and the reference preparation when administered in a single dose under fasting and high-fat meal conditions were studied, and the bioequivalence of the test preparation and the reference preparation was evaluated in humans. Secondary study purpose: Compare the safety of the test preparation and the reference preparation (trade name: Tamiflu®) of Oseltamivir Phosphate Capsules in healthy subjects.

The aim of the study was to investigate the bioavailability of Ambroxol Hydrochloride Dispersible Tablets (test preparation, 30 mg/tablet) produced by Zhuhai Tongyuan Pharmaceutical Co., Ltd. and Ambroxol Hydrochloride Tablets (reference preparation, trade name: SURBRONC, 30 mg/tablet, current licensee: Sanofi-aventis France) produced by Boehringer Ingelheim France under fasting/postprandial conditions, to compare the pharmacokinetic behaviors of the two preparations in healthy Chinese subjects, and to evaluate the bioequivalence of the two preparations.

Main purpose: Using pharmacokinetic parameters as the primary endpoint evaluation indicators, the pharmacokinetic behavior of the test preparation Teprenone Capsules (Specification: 50 mg, manufacturer: Zhuhai Tongyuan Pharmaceutical Co., Ltd.) and the reference preparation Teprenone Capsules (Specification: 50 mg, licensee: Eisai (China) Pharmaceutical Co., Ltd., trade name: Servier®) in healthy Chinese subjects after oral administration in the fasting/postprandial state was compared to evaluate the bioequivalence of the test preparation and the reference preparation. Secondary purpose: To observe the safety of the test preparation Teprenone Capsules and the reference preparation Teprenone Capsules in healthy Chinese subjects.