Delving into the Latest Updates on Dentaid SL with Synapse

Overview

This is a randomized, controlled clinical trial with two parallel groups in which 150 volunteers (75 per group) will receive either VITIS CPC Protect® mouthwash (Mouthwash with cetylpyridinium chloride (CPC) as an anti-plaque antiseptic at a concentration of 0.07%) or mouthwash without cetylpyridinium chloride, as control group Subjects included in the study will be followed for 90 days. Symptoms associated with vURTIs (viral upper respiratory tract infections) should be recorded, when they appear, to determine the existence of viral infections of the upper respiratory tract.
Symptoms and adverse effects will be recorded when the episode occurs. The assignment as VURIs will be made by the investigator once the diaries have been completed, or during the symptoms if possible.

Start Date15 Nov 2023

Sponsor / Collaborator

Dentaid SL

NCT05354986

/ CompletedNot Applicable

Impact of a Newly Formulated Tooth Paste in the Prevention/Elimination of Tooth Staining Associated With Adjunctive Use Chlorhexidine Mouth Rinses to Subgingival Instrumentation. A Randomized Clinical Trial

Dental staining may interfere with compliance with chlorhexidine mouth rinse use
Thus, developing strategies to control tooth staining associated with chlorhexidine use may be relevant for improving compliance. Thus, a new anti-staining toothpaste formulation (Dentaid, Barcelona, Spain) has been recently developed, aiming to interfere with the development of extrinsic staining associated with chlorhexidine use (preventive action), but also with the capacity of removing staining already formed. For that, the proposed formulation includes hexametaphosphate, tripolyphosphate and polyvinylpyrrolidone (PVP), within its ingredients. Thus, it may be relevant to test the efficacy of this new anti-staining toothpaste formulation in two consecutive randomized clinical trials (RCTs).
Objectives The primary objective of these RCTs will be to evaluate the capacity of preventing tooth staining, associated with the use of a chlorhexidine mouth rinse, adjunctive to subgingival instrumentation (step 2 of periodontal therapy) (RCT #1). As secondary objective, the capacity of eliminating or reducing tooth staining already present will be assessed (RCT #2).

Start Date01 Oct 2022

Sponsor / Collaborator

Universidad Complutense de Madrid

[+1]

NCT05356806

/ RecruitingNot Applicable

Incidence of Peri-implant Mucositis in Patients With Treated Periodontitis: a Prospective Study.

the objective of this study is to determine the incidence of peri-implant mucositis in patients with treated periodontitis and enrolled in periodontal maintenance and to evaluate the associated risk indicators. An analytical prospective observational study will be carried out, with an initial follow-up of 12 months.

Start Date10 Jan 2022

Sponsor / Collaborator

Universidad Complutense de Madrid

[+1]

100 Clinical Results associated with Dentaid SL

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Literatures (Medical) associated with Dentaid SL

Characterizing the oral microbiota of adolescents: results from the Generation R Study

Author: Blanc, Vanessa ; Medina-Gomez, Carolina ; Wolvius, Eppo ; Kragt, Lea ; Àlvarez, Gerard ; Arredondo, Alexandre ; Veenman, Francien ; Rivadeneira, Fernando

Abstract

Objective The objective of this study was to investigate the microbial signature of the oral cavity in caries-free adolescents without orthodontic treatment from the general population. We also aimed to identify lifestyle factors shaping oral microbiota composition and assess the impact of technical covariates related to sample collection and analysis. Methods For the cross-sectional analysis, 750 Dutch adolescents without caries or orthodontic treatment (16.1%) were selected from all participants from the Generation R Study with oral microbiota profiling (n = 4,646). Oral microbiota data was obtained from supragingival biofilm swabs using 16S rRNA sequencing (V3-V4 region), and analyzed at four levels; core microbiota, alpha diversity, beta diversity and differential abundance. Results Participants (13.6 ± 0.29 years, 56% male) shared a large core microbiota consisting of 23 different genera, with the five most abundant and prevalent—Streptococcus, Rothia, Haemophilus, Gemella, and Neisseria—being well-known early colonizers of the dental biofilm. Among participant characteristics, tooth brushing frequency emerged as the strongest determinant of microbiota composition. Compared to participants who brushed twice or more a day, those who brushed once or less, exhibited higher bacterial richness (Chao1; β:15.04, 95% CI:1.78;28.31) and higher Porphyromonas abundance (LFC:0.63, SD:0.16, q-value:0.002). The sampling time, identified as the most impactful technical covariate, showed a negative association with bacterial richness (early-morning vs late-afternoon: Chao1; β:-57.04, 95% CI:-77.44;-36.64). Conclusion This study revealed a high similarity in oral microbiota of adolescents from the general population at the genus level, while highlighting the influence of tooth brushing frequency, sex, and sugar consumption on bacterial composition. Clinical relevance The findings provide a valuable reference for future studies exploring the link between adolescents' oral microbiota and both oral and systemic health.