Shanghai Shikangte Pharmaceutical Co.,Ltd.

Healthy Chinese subjects were used as test subjects. A self-crossover design was used to determine the time course of dexamethasone plasma concentration in healthy subjects after administration of dexamethasone acetate tablets produced by Shanghai Shikangte Pharmaceutical Co., Ltd., and to estimate the corresponding pharmacokinetic parameters. Dexamethasone acetate tablets (trade name: DECTANCYL®) produced by SANOFI AVENTIS FRANCE were used as a reference to evaluate the bioequivalence between the preparations and observe the safety in healthy Chinese subjects.

The primary objective is to evaluate the bioequivalence of famotidine tablets (20 mg) produced by Shanghai Shikangte Pharmaceutical Co., Ltd. (test preparation) and Astellas Pharma's Famotidine Tablets (20 mg) (reference preparation) after a single oral dose in healthy adult subjects under fed conditions. The secondary objective is to monitor the drug safety of the subjects participating in the study through clinical biochemistry, physical examination and adverse event/serious adverse event monitoring.

The primary objective is to evaluate the bioequivalence of famotidine tablets (20 mg) produced by Shanghai Shikangte Pharmaceutical Co., Ltd. (test preparation) and Astellas Pharma's Famotidine Tablets (20 mg) (reference preparation) after a single oral dose in healthy adult subjects under fasting conditions. The secondary objective is to monitor the drug safety of the subjects participating in the study through clinical biochemistry, physical examination and adverse event/serious adverse event monitoring.