Delving into the Latest Updates on Sclavo Spa with Synapse

Overview

A simple two-step procedure for purifying F(ab)2 fragments of horse immunoglobulins is described. In the first step, the horse plasma is diluted, made up to 12% (w/v) with ammonium sulphate and digested with pepsin. In the second step, the previously dialyzed solution is chromatographed. Instead of a normal ion-exchange resin, a DEAE-cellulose, covalently linked to a synthetic vinyl polymer, was used (DEAE-Zeta-Prep). With this assembly it is possible to perform chromatography at a high flow-rate without the problems related to the use of large columns. The yield and purity of the final product are satisfactory. This method has been scaled up for industrial application.

Biologically active retro-inverso analogs of thymopentin

Author: Groggia, Antonio ; Pessi, Antonello ; Villa, Luigi ; Silvestri, Sergio ; Marcozzi, Giordana ; Mariotti, Sabina ; Sisto, Alessandro ; Nencioni, Luciano ; Verdini, Antonio S.

A report from a symposium on the preparation and biol. activity of thymopentin retro-inverso analogs.The retro-inverso modification at the N-terminal amide bond slowed enzymic cleavage yielding an analog with prolonged half-life in human plasma and an increased activity.An analog with 2 retro-inverso modifications was the most potent compound, over 200 times more potent than the parent compound

Large-scale peptide synthesis through continuous flow Fmoc-polyamide

Author: Longobardi, M. G. ; Caciagli, V. ; Pessi, A.

A report from a symposium on the large-scale solid-phase preparation of H-Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys-OH from 1-200g of polyamide resin.

100 Deals associated with Sclavo Spa

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100 Translational Medicine associated with Sclavo Spa

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Pipeline

Pipeline Snapshot as of 06 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Other

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