Delving into the Latest Updates on Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd. with Synapse

Overview

Tags

Immune System Diseases

Respiratory Diseases

Otorhinolaryngologic Diseases

Allergen extract

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Immune System Diseases	13
Infectious Diseases	4

Top 5 Drug Type	Count

Allergen extract	13
Small molecule drug	1

Top 5 Target	Count

Taste 2 receptors	1

Primary objective: To evaluate the efficacy of kubutan saponin A inhalation solution in patients with moderate chronic obstructive pulmonary disease (COPD) for 29 consecutive days. Secondary objective: To evaluate the safety of kubutan saponin A inhalation solution in patients with moderate chronic obstructive pulmonary disease (COPD) for 29 consecutive days.

Start Date16 Apr 2024

Sponsor / Collaborator

Shanghai Kaiyi Pharmaceutical Technology Co., Ltd.

CTR20232303 / CompletedPhase 1

一项在中国志愿者中探索烟曲霉点刺液安全性及有效性的临床研究—单中心、开放的I期临床研究

[Translation] A clinical study to explore the safety and efficacy of Aspergillus fumigatus prick solution in Chinese volunteers—a single-center, open-label phase I clinical study

本研究通过对志愿者进行6种不同剂量的烟曲霉点刺液梯度试验，考察在一定剂量范围内的安全性及有效性，为确定烟曲霉点刺液后期的临床剂量提供参考。

[Translation]

This study conducted a gradient test of 6 different doses of Aspergillus fumigatus prick solution on volunteers to examine the safety and efficacy within a certain dosage range, providing a reference for determining the later clinical dosage of Aspergillus fumigatus prick solution.

Start Date05 Sep 2023

Sponsor / Collaborator

Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

100 Clinical Results associated with Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

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0 Patents (Medical) associated with Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

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4

Literatures (Medical) associated with Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

01 Jan 2019·Journal of Cosmetics, Dermatological Sciences and Applications

Effects of Silk Fibroin Moisturizing Cream on Acetone/Ether-Induced Dry Skin Pruritus in Mice

Author: He, Jianming ; Tong, Yuling

Objectives: The morbidity of dry and itchy skin was high during a person's lifetime and it had a significant neg. impact.This study aimed to investigate the pos. effect of silk fibroin moisturizing cream on dry skin pruritus induced by acetone/ether-water (AEW) method in mice.Method: We established a dry skin model in mice with AEW treatment, and the control group was treated with ultrapure water.The mice in AEW model group were locally administrated with silk fibroin moisturizing cream (SilkArmor).The transepidermal water loss (TEWL), scratching behavior, condition of skin erythema, skin histol. (by hematoxylin-eosin staining) and the results of electron microscopy were measured to evaluate the pos. effect of SilkArmor on dry and itchy skin in mice.Results: The TEWL value, spontaneous scratching behavior and erythema score were significantly increased after AEW modeling compared with the control group.There was no significant difference in the TEWL value, scratching behavior and erythema score between the SilkArmor group and the control group (P > 0.05).Compared with the AEW group, the value of TEWL, scratching behavior and the erythema score of mice in the AEW + SilkArmor group were improved, with statistically significant differences (P < 0.05).Skin histopathol. and electron microscopy also showed that SilkArmor had certain improvement and repairment on AEW-induced skin pathol. changes.Conclusions: A dry skin model was successfully established in this experiment, showing that SilkArmor brought an obvious alleviation to AEW-induced dry and itchy skin in mice.

01 Sep 2017·Applied Microbiology and Biotechnology

Erratum to: Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis

Article

Author: Zhang, Yue ; Tang, Zheng-Kun ; Zhang, Jie ; Pang, Ai-Ping ; Zhao, Guang-Rong ; Lin, Chun-Yan ; Li, Xiao-Mei ; Qiao, Jianjun

There were errors in several figures.The corrected figures are provided.

01 Aug 2017·Applied Microbiology and Biotechnology

Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis

Article

Author: Zhang, Yue ; Tang, Zheng-Kun ; Zhang, Jie ; Pang, Ai-Ping ; Zhao, Guang-Rong ; Lin, Chun-Yan ; Li, Xiao-Mei ; Qiao, Jianjun

Monensin, a polyether ionophore antibiotic, is produced by Streptomyces cinnamonensis and worldwide used as a coccidiostat and growth-promoting agent in the field of animal feeding. The monensin biosynthetic gene cluster (mon) has been reported. In this study, the potential functions of three putatively pathway-specific regulators (MonH, MonRI, and MonRII) were clarified. The results from gene inactivation, complementation, and overexpression showed that MonH, MonRI, and MonRII positively regulate monensin production. Both MonH and MonRI are essential for monensin biosynthesis, while MonRII is non-essential and could be completely replaced by additional expression of monRI. Transcriptional analysis of the mon cluster by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and electrophoresis mobility shift assays (EMSAs) revealed a co-regulatory cascade process. MonH upregulates the transcription of monRII, and MonRII in turn enhances the transcription of monRI. MonRII is an autorepressor, while MonRI is an autoactivator. MonH activates the transcription of monCII-monE, and upregulates the transcription of monT that is repressed by MonRII. monAX and monD are activated by MonRI, and upregulated by MonRII. Co-regulation of those post-polyketide synthase (post-PKS) genes by MonH, MonRI, and MonRII would contribute to high production of monensin. These results shed new light on the transcriptional regulatory cascades of antibiotic biosynthesis in Streptomyces.

100 Deals associated with Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

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100 Translational Medicine associated with Zhejiang Wolwo Bio-Pharmaceutical Co., Ltd.

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Pipeline

Pipeline Snapshot as of 14 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

IND Application

1

Phase 1 Clinical

Phase 2 Clinical

3

2

Phase 3 Clinical

NDA/BLA

3

4

Approved

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Skin Prick Solution for Artemisia annua Pollen Allergens	Rhinitis, Allergic, Seasonal More	Approved
Dermatophagoides Farinae Drops(Wolwo Bio-Pharma)	Hypersensitivity More	Approved
Skin Prick Solution for Humulus japonicus Pollen Allergens	Rhinitis, Allergic, Seasonal More	Approved
Skin Prick Solution for Betula platyphylla Suk. Pollen Allergens	Rhinitis, Allergic, Seasonal More	Approved
Platanus Acerifolia Pollen Prick solution(Zhejiang Wolwo Bio-Pharmaceutical)	Anaphylaxis More	NDA/BLA