University of Shaoxing

Near early T-cell precursor acute lymphoblastic leukemia represents a distinct subtype of T-cell acute lymphoblastic leukemia characterized by specific immunophenotypic and molecular biological characteristics. Currently, no standardized treatment protocol exists.

This study presents a case of near early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) characterized by plasmacytoid dendritic cell proliferation, which manifested clinically through pancytopenia and generalized multiple rashes.

The patient underwent successful treatment with chemotherapy consisting of Venetoclax combined with HAG regimen administered for one cycle.

This case report provides preliminary evidence suggesting that the combination of Venetoclax with HAG (homoharringtonine, cytarabine, and granulocyte colony-stimulating factor) regimen may constitute an effective and tolerable therapeutic approach for patients with near ETP-ALL. However, these initial observations necessitate further validation through comprehensive clinical studies with larger sample sizes to definitively establish the treatment's efficacy and safety profile.

Extraction of uranium (U(VI)) from fluoride-rich radioactive wastewater is essential for nuclear energy development and environmental remediation.The current investigation delves into the viability of employing Dictyophora indusiata biochar (DIBC) materials modified with different chem. reagents (H₃PO₄, polyaniline, NaOH and KMnO₄) for the effective capture of U(VI) from highly fluoridated wastewater.By comparing the effects of different modification methods, the KMnO₄-modified DIBC (KM-DIBC) showed the most significant removal effect, which was attributed to its huge sp. surface area, strong heterogeneity and a profusion of O-containing functional groups.The maximum removal capacity of U(VI) by KM-DIBC reached 182.90 mg·g^-1, marking a remarkable enhancement of 2.15 times compared to the original DIBC, and the uptake capacity remained as high as 132.44 mg·g^-1 even in an environment with high concentration of fluoride ions (c (F^-) = 10 g·L^-1).Furthermore, KM-DIBC exhibited excellent stability in complex environments where multiple ions coexist, further confirming its great potential for practical applications.Detailed studies and analyses have indicated that the mechanism by which KM-DIBC removes U(VI) likely encompasses a sophisticated interplay of cation-π interactions, electrostatic attraction, coordination and Lewis acid-base interactions.This investigation not only provides new materials and methods for the effective removal of U(VI) from high-fluoride wastewater, but also provides important theor. basis and tech. support in the field of environmental remediation and nuclear resource recovery.

This study aims to evaluate the safety of primary anastomosis (PA) without a protective stoma in emergency left colon surgery.

A systematic search was conducted in the PubMed, Web of Science, Embase, and Cochrane Library databases, covering articles from the inception of these databases until September 2024. The primary outcome was the incidence of anastomotic leakage.

The PA group exhibited a higher incidence of anastomotic leakage compared to the stoma surgery group (odds ratios (OR) = 5.86, p = 0.05). However, in cases of perforated diverticulitis (OR = 3.80, p = 0.19) and malignant obstruction (OR = 5.40, p = 0.23), the PA group did not show an increased risk of anastomotic leakage. In terms of other outcomes, the reoperation rate in the PA group was higher compared to the stoma surgery group (OR = 1.89, p < 0.001). However, there were no statistically significant differences in the mortality rate (OR = 1.04, p = 0.80) or the incidence of postoperative complications (OR = 1.50, p = 0.27) between the two groups.

Primary anastomosis without a protective stoma is generally safe and can be considered a viable option in emergency left colon surgery.