Evaluation of Post Operative Pain Following Reciprocating and Rotary Heat-treated NiTi Instrumentation of Root Canals: a Randomized Controlled Clinical Trial

The present clinical evaluation was planned for comparing the post-operative pain incidence in maxillary premolar teeth with acute irreversible pulpitis treated by recently introduced heat treated TruNatomy TM and other widely studied heat-treated files Hyflex EDM, Protaper Gold and one heat-treated reciprocating EdgeFile in single-visit root canal treatment.

Start Date03 Jan 2021

Sponsor / Collaborator

The Tamil Nadu Dr. M.G.R. Medical University

NCT04248803

/ RecruitingNot ApplicableIIT

Efficacy of Gluma Desensitizer in Controlling the Immediate Post-treatment Sensitivity in Etch-and-rinse and Self-etch Adhesive Bonded Occlusal Composite Restorations

To evaluate the effect of Gluma desensitizer in controlling immediate post-treatment sensitivity in posterior occlusal composite restorations.

Start Date06 Feb 2020

Sponsor / Collaborator

The Tamil Nadu Dr. M.G.R. Medical University

100 Clinical Results associated with The Tamil Nadu Dr. M.G.R. Medical University

0 Patents (Medical) associated with The Tamil Nadu Dr. M.G.R. Medical University

918

Literatures (Medical) associated with The Tamil Nadu Dr. M.G.R. Medical University

01 Jun 2025·Current Computer-Aided Drug Design

In-silico Design, ADMET Screening, Prime MM-GBSA Binding Free Energy Calculation and MD Simulation of Some Novel Phenothiazines as 5HT₆R Antagonists Targeting Alzheimer’s Disease

Article

Author: Natarajan, Ramalakshmi ; Vediappan, Prema ; Arumugam, Meena

Background:Alzheimer's disease is a type of dementia that affects neuronal function, leading to a decline in cognitive functions. Serotonin-6 (5HT6) receptors are implicated in the etiology of neurological diseases. 5HT6 receptor antagonists act as anti-dementia agents. PDB ID: 7YS6 represents a membrane protein, and amplification and overexpression of this protein are associated with Alzheimer's disease. Coumarin-fused phenothiazines are significant anti-Alzheimer's agents due to their inhibitory activity on the Serotonin- 6 receptor.Objectives:Numerous previously unreported Coumarin-substituted Phenothiazines [A2 to A50] were designed using in-silico methods to evaluate their 5HT6 receptor antagonistic activity. Molecular modeling techniques were employed to study the ligands [A2 to A50] in interaction with the Serotonin-6 receptor (PDB ID: 7YS6) using Schrödinger Suite 2019-4.Methods:Molecular modeling studies of the designed ligands [A2 to A50] were conducted using the Glide module. In-silico ADMET screening was performed using the QikProp module, and binding free energy calculations were carried out using the Prime MM-GBSA module within the Schrödinger Suite. The binding affinity of the designed ligands [A2 to A50] towards 5HT6 receptors was determined based on Glide scores. Subsequently, ligand A31 underwent a 100 ns molecular dynamics simulation using the Desmond module of Schrödinger Suite 2020-1, which is based in New York, NY.Results:The majority of the designed ligands exhibited strong hydrogen bonding interactions and hydrophobic associations with the serotonin-6 receptor, which hinder its activity. These ligands achieved remarkable Glide scores within the range of -4.2859 to -7.7128, in comparison to reference standards such as Idalopirdine (-7.78149), Intepirdine (-5.20103), Latrepirdine (-5.54853), and the co-crystallized ligand (-7.02889). In-silico ADMET properties for these ligands fell within the recommended values for drug-likeness. It is worth noting that the MMGBSA binding free energy of the most potent inhibitor was positive, indicating a strong binding interaction. Additionally, the dynamic behavior of the protein (7YS6)-ligand (A31) complex was studied by subjecting ligand A31 to a 100 ns molecular dynamics simulation.Conclusion:The results of this study reveal strong evidence supporting the potential of coumarin- substituted phenothiazine derivatives as effective Serotonin-6 receptor antagonists. Ligands [A2 to A50], which exhibited noteworthy Glide scores, hold promise for significant anti- Alzheimer activity. Further in-vitro and in-vivo investigations are warranted to explore and confirm their therapeutic potential.

01 Apr 2025·The American Journal of Emergency Medicine

MINOCA post-blood donation: Beyond volume loss

Letter

Author: Sanjay, Patne ; Jena, Narendra Nath ; Thirumalaikolundusubramanian, Ponniah ; Senthilkumaran, Subramanian

28 Mar 2025·The Journal of Contemporary Dental Practice

Efficacy of Hamstring Stretching, Ultrasound Therapy, and Pressure Pain Threshold for Masseter Muscle in TMJ Dysfunction Patients: A Randomized Controlled Trial

Article

Author: Ramachandran, Sajani ; Kurusumuthu, Frankin Shaju M ; Irusappan, Srikanth

AIMThis study aims to evaluate the impact of adding bilateral hamstring muscle stretching to pressure pain threshold and ultrasound therapy, compared to using pressure pain threshold and ultrasound therapy alone, on pain reduction and maximum vertical mouth opening (MVMO) in individuals with temporomandibular disorders (TMD).MATERIALS AND METHODSA total of 56 participants diagnosed with TMD were randomly allocated into 2 groups: The Experimental Group, which received bilateral hamstring stretching, pressure pain threshold application, and ultrasound therapy, and the control group, which received only pressure pain threshold and ultrasound therapy. The study included participants of both genders, aged between 18 and 35 years, with a previous history of TMD pain lasting no longer than 6 months. Assessments were conducted at baseline and after 5 treatment sessions per week over 1 week. Pain levels were measured using the visual analog scale (VAS), and MVMO was assessed using a vernier caliper. Data were recorded and statistically analyzed.RESULTSThe results showed a significant reduction in pain and an increase in MVMO in both groups. In the Experimental Group, the mean pain score on the VAS decreased from 6.8 ± 1.2 to 2.9 ± 1.1, whereas in the control group, it decreased from 6.7 ± 1.3 to 4.1 ± 1.2 (p < 0.001). Similarly, MVMO improved significantly, with an increase from 31.4 ± 2.6 mm to 39.8 ± 2.1 mm in the Experimental Group, compared to an increase from 31.2 ± 2.8 mm to 36.1 ± 2.4 mm in the control group (p < 0.001). The between-group comparison showed a significant difference in pain reduction and MVMO improvement in the Experimental Group compared to the control group (p < 0.001).CONCLUSIONHamstring stretching combined with ultrasound therapy and pressure pain threshold application was significantly more effective in reducing TMD-related pain and improving MVMO than pressure pain threshold and ultrasound therapy alone. These findings indicate that integrating hamstring stretching into TMD treatment protocols could improve rehabilitation outcomes.CLINICAL SIGNIFICANCEThe findings of this study highlight the potential benefits of integrating hamstring stretching into standard physiotherapy interventions for TMD. Given the significant improvements observed in pain reduction and MVMO, clinicians may consider including hamstring flexibility exercises in rehabilitation programs for TMD patients to achieve better functional outcomes. How to cite this article: Irusappan S, Kurusumuthu FSM, Ramachandran S. Efficacy of Hamstring Stretching, Ultrasound Therapy, and Pressure Pain Threshold for Masseter Muscle in TMJ Dysfunction Patients: A Randomized Controlled Trial. J Contemp Dent Pract 2025;26(1):34-39.

100 Deals associated with The Tamil Nadu Dr. M.G.R. Medical University

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