[Translation] A randomized, double-blind, placebo-controlled, first-in-human Phase 1 study of oral ALG-000184 to evaluate single-dose escalation (Part 1) and multiple-dose escalation (Part 2) in healthy volunteers and chronic Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Dosing (Part 3) in Subjects with Hepatitis B.
评估口服ALG-000184在健康志愿者单次给药剂量递增(第1部分)和多次给药剂量递增(第2部分)以及慢性乙型肝炎受试者多次给药(第3部分)的安全性、耐受性、药代动力学和药效学。
[Translation] To evaluate the efficacy of oral ALG-000184 in single-dose escalation (Part 1) and multiple-dose escalation (Part 2) in healthy volunteers and multiple-dose (Part 3) in chronic hepatitis B subjects Safety, Tolerability, Pharmacokinetics and Pharmacodynamics.