Conjugated microporous polymers (CMPs) represent an innovative category of porous materials distinguished by their unique amalgamation of π-conjugated systems and permanently microporous frameworks.Due to their inherent microporosity, large surface area, and exceptional stability, CMPs have attracted considerable attention across numerous fields, especially in membrane separationThis review provides an in-depth summary of the latest developments in CMP-based membranes, highlighting their fascinating properties, diverse fabrication strategies, and promising applications in various separation processes.Initially, the key characteristics that determine the separation performance of CMP-based membranes, including pore size, hydrophilicity/hydrophobicity, stability, and processability, are discussed.Then, a comprehensive examination of their diverse fabrication strategies is presented, highlighting the specific steps along with the advantages and disadvantages of each method.Furthermore, we explore the applications of CMP membranes in gas separation, water purification, organic solvent nanofiltration, and other emerging areas.Finally, we highlight the current challenges facing CMP-based membranes and propose potential future directions for the advancement of these sophisticated membrane materials.