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Knee Osteoarthritis (OA) is one of the most frequent causes of physical disability and pain among adults. Recent evidence suggests that shorter exercise programs that incorporate kinesthesia, balance and agility (KBA) techniques may result in more rapid symptom relief and functional improvements in comparison to traditional therapeutic exercise. KBA techniques are designed to improve dynamic joint stability by using a series of activities which challenge balance and coordination. To determine the independent effects of KBA training on functional abilities, it is necessary to test it as a training program unto itself. The proposed clinical trial is designed to do this by using three training groups: KBA only; lower extremity strength training only; and a combination of the two. The total exercise time and intensity of each condition will be approximately equal. A non-exercise group will control for any effects related to the testing procedures and the passage of time. Community volunteer men and women age 50 and over with physician diagnosed symptomatic knee OA will participate.

Start Date01 Jan 2009

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University of Zululand

100 Clinical Results associated with University of Zululand

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0 Patents (Medical) associated with University of Zululand

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2,932

Literatures (Medical) associated with University of Zululand

01 Aug 2025·Vacuum

Selenium migration and SiC structural evolution post helium and selenium Co-implantation and annealing

Author: Mthalane, S. ; Abdelbagi, H. A. A. ; Skuratov, V. A. ; Mtshali, C. B. ; Ntshangase, S. S. ; Hlatshwayo, T. T. ; Li, B. S.

Polycrystalline SiC samples were first implanted with 200 keV selenium (Se) ions at room temperature (RT) to a fluence of 1 x 10¹⁶ cm^-2.Thereafter, some of the pre-implanted SiC samples were sep. implanted with helium (He) ions of 17 keV to a fluence of 1 x 10¹⁷ cm^-2 at RT and 500 °C.The samples were then annealed in a vacuum at 1000 °C for 5 h.Raman spectroscopy and transmission electron microscopy (TEM) were used to study the influence of Se and He co-implantation and annealing on the microstructure of SiC.Rutherford backscattering spectrometry (RBS) was used to study the migration behavior of Se in SiC before and after co-implantation and annealing.Implantation of Se at RT amorphized the SiC near the surface implanted region.Co-implantation at RT created a high portion of free carbon atoms in the damaged region accompanied by the formation of He nano-bubbles, while co-implantation at 500 °C led to some recrystallization of initially amorphous SiC and formation of larger He bubbles.Annealing at 1000 °C caused some recrystallization in both as-implanted (SiC implanted with Se only) and co-implanted samples.However, the recrystallization was accompanied by the formation of graphite crystals (with an average size of 10 nm) in the samples co-implanted at RT.This indicates that co-implantation at RT induces more detrimental effects on the phys. integrity of SiC.RBS results showed no change in Se distribution in SiC after subsequent implantation with He ions at RT and 500 °C.However, annealing at 1000 °C caused the Se atoms to migrate towards the bulk of SiC in the co-implanted samples, while no significant migration of Se atoms was observed in the as-implanted samples (SiC implanted with Se only) annealed under the same conditions.This suggests that He assisted Se migration in SiC.

01 Jun 2025·Toxicology in Vitro

Prolonged exposure to simvastatin affects coenzyme Q9/10 status leading to impaired mitochondrial respiratory capacity and reduced viability of cultured cardiac cells

Article

Author: Muller, Christo J F ; Mthembu, Sinenhlanhla X H ; Nkambule, Bongani B ; Silvestri, Sonia ; Dludla, Phiwayinkosi V ; Mazibuko-Mbeje, Sithandiwe E ; Orlando, Patrick ; Tiano, Luca

This study investigates the effects of prolonged simvastatin exposure on coenzyme Q_9/10 (CoQ_9/10) levels, an essential component of antioxidant defense, in cultured cardiac cells. Statins, commonly used to manage dyslipidemia and reduce cardiovascular risk, may impair mitochondrial function, but their impact on CoQ₁₀ depletion and oxidative stress is not well understood. We examined the influence of simvastatin on mitochondrial oxidative capacity, reactive oxygen species (ROS) production, and CoQ_9/10 status at concentrations of 0.3, 0.6, 1.25, 2.5, 5, 10, and 20 μM, over durations of 24, 48, and 72 h. Using an in vitro model of cultured H9c2 cardiomyoblasts, our results showed that short-term exposure (24 h) at lower concentrations (<5 μM) enhanced cytosolic and mitochondrial ROS levels without affecting mitochondrial function or CoQ_9/10 status. However, prolonged exposure to higher concentrations (≥10 μM for >48 h) resulted in impaired mitochondrial oxidative capacity, indicated by increased proton leak and elevated ROS levels, which were followed by significantly reduced cell viability. These findings suggest that prolonged, high-dose simvastatin exposure may disrupt the oxidative balance of CoQ_9/10, leading to myocardial injury. This research addresses a gap in understanding the long-term effects of statins on mitochondrial health and underscores the need for further studies to optimize statin therapy and minimize adverse effects on myocardial function.

17 Apr 2025·Institutes of Higher Education (IHE) and Workforce Collaboration for Digital Literacy

Bridging the Digital Divide in the Access and Usage of Technology Through Digital Literacy in Rural Vocational Schools

Author: Ndjama, Joelle Danielle Ngo

The digital divide phenomenon presents a significant challenge in rural vocational schools, where disparities in access to and utilisation of technology can hinder educational opportunities for marginalised individuals. Despite the extensive body of research on the integration of digital technologies in academic settings, there remains a notable deficiency in understanding effective digital literacy practices tailored specifically for vocational education. This study employs resource and appropriation theory to explore the inequalities in technological access and usage within vocational institutions. The investigation identifies four distinct types of digital divides: the physical access divide, the skills access divide, the usage divide, and the network or internet divide. The findings suggest that bridging the digital divide necessitates a collaborative approach involving four critical stakeholders: vocational institutions, industry partners, government agencies, and rural communities, thereby fostering an inclusive environment.

100 Deals associated with University of Zululand

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100 Translational Medicine associated with University of Zululand

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Pipeline

Pipeline Snapshot as of 12 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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