Farmoquímica SA

2. Participants will:
* Take nitazoxanide 600mg (or placebo) orally twice daily for 7 days, for a total of 14 doses.
* Visit the clinic on the 7th day of treatment for a check-up and safety tests.
* Keep a diary of their symptoms and other medications used

The goal of this clinical trial is to identify the immunophenotypic profile of the local immune response, the cervicovaginal microenvironment and the microbiological profile of women with CIN 3 treated with imiquimod. Participants will be divided in 3 groups: CIN 3 who will use 16 doses of imiquimod in the uterine cervix, applied twice a week and will be treated with LEEP procedure; 2) patients with CIN 3 who will undergo standard treatment with LEEP procedure; 3) patients with negative cytology and HPV (human papillomavirus) test. Blood and cervicovaginal lavage collections will be performed at different times, for comparisons between cellular response profiles to imiquimod during treatment and baseline levels in healthy patients.