Delving into the Latest Updates on Laboratorios Alter SA with Synapse

Overview

Eterylate (I) [62992-61-4] was prepared by coupling p-(2-hydroxyethoxy)acetanilide [50375-15-0] with o-acetoxybenzoyl chloride [5538-51-2] and tested for antiinflammatory and analgesic activities.The activities of I were similar to those of acetylsalicylic acid and benorylate in equimol. doses.The oral LD₅₀ in mice for I, benorylate, and acetylsalicylic acid, were 3160, 1551, and 1259 mg/kg, resp.The gastrointestinal lesions observed after treatment for 30 days revealed that both I and benorylate were tolerated better than acetylsalicylic acid.Further, I had the advantage of causing less gastric lesioning and less hemorrhaging.Phys. and chem. properties of I are discussed.

Archivos de Farmacologia y Toxicologia

Effect of eterylate, benorylate and acetylsalicylic acid on glycemia in normal and experimental diabetic rats

Author: Armijo, M. ; Ortega, M. P. ; Alonso, S.

The effects of acetylsalicylic acid (I) [50-78-2] on blood sugar levels in normal and streptozotocin-diabetic rats were compared with those of its (acetylamino)phenyl ester, benorylate (II) [5003-48-5], and its [(acetylamino)phenoxy]ethyl ester, eterylate [62992-61-4], at equimolar doses.All 3 drugs had a hypoglycemic effect in diabetic animals when administered orally at a high dose (500 mg/100 g feed, calculated as I), but only II decreased blood sugar levels in normal rats.

Archivos de Farmacologia y Toxicologia

Relation between antiinflammatory activity and lipophilicity of new indomethacin phenol esters

Author: Sunkel, C. ; Armijo, M. ; Dorrego, F.

Hansch anal. of 7 indomethacin phenol esters showed that antiinflammatory activity increased with increasing lipophilicity.Preparation of the compounds from indomethacin chloride (I) and the corresponding phenols is described.

100 Deals associated with Laboratorios Alter SA

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100 Translational Medicine associated with Laboratorios Alter SA

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Pipeline

Pipeline Snapshot as of 18 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

PCA-50938 ( VDCCs )	Hypertension More	Pending
PCA-50941 ( VDCCs x calcium channel )	Hypertension More	Pending
PCA-50922 ( calcium channel )	Epilepsy More	Pending