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Overview

Basic Info

Introduction

The Qingdao Marine Biomedical Research Institute is a privately-owned organization based in China, specializing in biomedical research.

Tags

Digestive System Disorders

Neoplasms

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	1

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

Tubulin	1

Stimulating the STING signaling pathway for immune system activation is considered a promising strategy for cancer treatment. However, activating the STING pathway can lead to adverse effects, as aberrant activation or specific mutations in STING may result in autoimmune and inflammatory diseases. Therefore, the development of STING inhibitors is equally important. In this study, we first introduced hydroxyl groups into the STING inhibitors C170 and H151, creating functional sites for further modification. Then the introduction of various substituents resulted in the identification of more potent inhibitors, Y2 and HY2, which effectively suppressed the activation of the STING pathway in THP1 and RAW264.7 cells. Compounds Y2 and HY2 demonstrated potent anti-inflammatory effects in mice cisplatin-induced acute kidney injury models by inhibiting the STING pathway. Collectively, Y2 and HY2 warrant further investigation as novel anti-inflammatory agents.

01 May 2025·Carbohydrate Research

Carboxyl-converting titration versus other methods for the uronic acid content analysis of alginate oligosaccharide

Article

Author: Shao, Meng ; Li, Quancai ; Liu, Hao ; Lv, Youjing ; Sun, Yuanyuan ; Yang, Yue ; Zhou, Hui ; Yu, Guangli ; Zhao, Xia

This study presents a carboxyl-conversing titration method for determining the uronic acid content of alginate oligosaccharide (AOS). All C6 carboxyl groups on the monosaccharide residues of AOS were initially converted into carboxylates, which were subsequently transformed into carbonates through carbonization and incineration. Quantification was finally done through acid titration. The AOS content, which was represented by the amount of monosaccharide residues (ManA and GulA residues) in AOS sample, was calculated based on the stoichiometric relationship between the C6 carboxyl group and monosaccharide residue. To evaluate its performance, the carboxyl-conversing titration method was compared with the sulfuric acid-carbazole method and 1-phenyl-3-methyl-5-pyrazolone (PMP) pre-column derivatization high performance liquid chromatography (PMP-HPLC) method. The content of the uronic acid in AOS sample were detected 96.24 % ± 0.42 % using the carboxyl-conversing titration method, 186.85 ± 0.49 % (ManA/GulA = 1/1 as the reference standard) using the sulfuric acid-carbazole method, and 3.00 ± 0.08 % using the PMP-HPLC method. The carboxyl-conversing titration method demonstrated the highest accuracy of the content value. The validation of this method was also confirmed in the terms of specificity, limits of detection and quantification, recovery, repeatability, intermediate precision and durability. Compared to the sulfuric acid-carbazole and PMP-HPLC methods, the carboxyl-conversing titration method was proved easy to operate, reliable, and independent of reference standards. This innovative method offers a promising solution for accurately determining AOS content in laboratory and industrial settings.

01 Apr 2025·Bioorganic Chemistry

Design, synthesis, and anti-cancer evaluation of the novel conjugate of gemcitabine's ProTide prodrug based on CD13

Article

Author: Xu, Wenfang ; Chen, Yuxin ; Zhao, Jianchun ; Jia, Geng ; Jiang, Yuqi ; Jing, Fanbo ; Zhang, Liang ; Wang, Xuejian ; Li, Zhongqiang ; Li, Xiaoyang ; Sun, Simin

NUC1031 is a gemcitabine ProTide prodrug which is currently undergoing phase III. CD13 inhibitor bestatin is utilized as an adjunct therapy in conjunction with chemotherapy for cancer treatment, which has limitations in cytotoxic efficacy. In this study, we designed and synthesized a novel series of bestatin-gemcitabine's ProTide prodrug conjugates aimed at enhancing the antitumor efficacy of NUC1031. The representative compound 5f demonstrates a 10-fold increase in anti-proliferative activity compared to NUC-1031, with an IC₅₀ of 8.5 nM against the prostate cancer cell line 22Rv1. In vitro and in vivo pharmacokinetic studies revealed that compound 5f gradually degrades into the metabolic product 17, potentially extending its anti-tumor activity. 5f demonstrates significant in vivo anti-tumor activity in 22Rv1 xenograft tumor models. Our findings indicate that 5f shows strong potential for further development as a candidate for the treatment of prostate cancer.

100 Deals associated with Marine Biomedical Research Institute of Qingdao

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100 Translational Medicine associated with Marine Biomedical Research Institute of Qingdao

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Pipeline

Pipeline Snapshot as of 13 May 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

2

1

IND Approval

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

BG-136	Solid tumor More	IND Approval
Deuterated Plinabulin (Marine Biomedical Research Institute of Qingdao) ( Tubulin )	Neoplasms More	Preclinical
MBRI-003	Inflammatory Bowel Diseases More	Preclinical