Delving into the Latest Updates on Hubei University of Technology with Synapse

Overview

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Neoplasms

Respiratory Diseases

Infectious Diseases

Oncolytic virus

Synthetic peptide

Recombinant polypeptide

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Neoplasms	3
Infectious Diseases	1

Top 5 Drug Type	Count

Synthetic peptide	1
Oncolytic virus	1
Genetically engineered subunit vaccine	1
Recombinant polypeptide	1

Top 5 Target	Count

GM-CSF(Macrophage colony stimulating factor 2)	1
SARS-CoV-2 S protein	1
MDM2 x MDMX	1
CTNNB(Beta catenins)	1

Higher-order structures hierarchy of κ-carrageenan in the presence of potassium was reported.Yet, the destiny of κ-carrageenan in higher-order structures in the colon and their impacts on the gut microbiota community remains to be revealed.This study aims to investigate the fermentation behaviors and trace the structural change of higher-order structures of κ-carrageenan during in vitro fermentationHerein, κ-carrageenan gels were induced in the presence of 10, 40, and 70 mmol/L potassium ions, and a structural-hierarchical transition from secondary to quaternary structures was observed using an AFM and TEM.Results from GPC-MALLS, TLC, IEC, and GC indicated that Single helixes were partially fermented by fecal microbiota, while supercoiled helixes (tertiary structures) and intertwined helixes networks (quaternary structures) were hardly fermented.Tracing the structural change of higher-order κ-carrageenan suggested that the single helixes were partially deformed, as shown by the 60% reduction of single helixes width, while supercoiled helixes were more resistant to fermentation compared to single helixes.The super-strands networks were hardly fermented as their width distribution center had been sustained at around 90 nm from 12 to 48 h.In addition, the 16S rRNA gene (V3-V4) amplicon sequencing results indicated that Bifidobacterium longum showed a pos. correlation to the structural hierarchy (R = 0.734, p < 0.01).Together, the higher-order structures hierarchy of κ-carrageenan can resist degradation by human gut microbiota.

01 Jan 2025·Food Chemistry

Highly ordered aggregation of soy protein isolate particles for enhanced gel-related properties through konjac glucomannan addition

Article

Author: Zhang, Binjia ; Tu, Wenyao ; Jiang, Fatang ; Li, Kexin ; Liu, Xizhong ; Qiao, Dongling

This study assessed the effect of konjac glucomannan (KGM) on the aggregation of soy protein isolate (SPI) and its gel-related structure and properties. Raman results showed that KGM promoted the rearrangement of SPI to form more β-sheets, contributing to the formation of an ordered structure. Atomic force microscopy, confocal laser scanning microscopy, and small-angle X-ray scattering results indicated that KGM reduced the size of SPI particles, narrowed their size distribution, and loosened the large aggregates formed by the stacking of SPI particles, improving the uniformity of gel system. As the hydrogen bonding between the KGM and SPI molecules enhanced, a well-developed network structure was obtained, further reducing the immobilized water's content (T₂₂) and increasing the water-holding capacity (WHC) of SPI gel. Furthermore, this gel structure showed improved gel hardness and resistance to both small and large deformations. These findings facilitate the design and production of SPI-based gels with desired performance.

01 Jan 2025·Journal of Colloid and Interface Science

In-situ strategies for melamine-functionalized graphene oxide nanosheets-based nanocomposite proton exchange membranes in wide-temperature range applications

Article

Author: Zhang, Rong ; Li, Xiao ; Hu, Shengfei ; Fu, Xudong ; Zhao, Feng ; Bao, Xujin ; Wang, Bei ; Ling, Zhiwei ; Yang, Jun ; Liu, Qingting

The traditional preparation of nanocomposite proton exchange membranes (PEM) is hindered by poor organic-inorganic interface compatibility, insufficient proton-conducting sites, easy aggregation of nanoparticles, and difficulty in leveraging nanoscale advantages. In this study, a novel method involving electrochemical anodic oxidation exfoliation was employed to prepare melamine-coated graphene oxide (Me@GO), which was subsequently subjected to in-situ polymerization with poly(2,5-benzimidazole) (ABPBI) to prepare a Me@GO/ABPBI composite proton exchange membrane. Benefiting from the strong hydrogen bonding and large π stacking interactions, melamine (Me) tightly bound to graphene oxide (GO), effectively preventing the secondary aggregation of GO after exfoliation. Moreover, the abundant alkaline functional groups of melamine enhanced the enhancement of phosphoric acid (PA) retention in the Me@GO/ABPBI membranes, thereby increasing the number of proton-conducting sites. The experimental results indicated that the introduction of Me@GO enhanced membrane properties. For Me@GO at a concentration of 1 wt%, the tensile strength of the 1Me@GO/ABPBI composite membrane reached 207 MPa, nearly 2.52 times that of the pure membrane. The proton conductivity of the 1Me@GO/ABPBI composite membrane reached 0.01 S cm^-1 across a wide temperature range (40-180 °C), peaking at 0.087 S cm^-1 at 180 °C. Additionally, a single-cell incorporating the 1Me@GO/ABPBI composite membrane achieved a peak power density of 0.304 W cm^-2 at 160 °C, nearly 1.46 times that of the pure membrane. Benefiting from the well-dispersed and PA-enriched proton channels provided by Me@GO, the Me@GO/ABPBI composite membrane exhibits excellent prospects for wide-temperature range (40-180 °C) applications.

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100 Translational Medicine associated with Hubei University of Technology

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Pipeline

Pipeline Snapshot as of 07 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

1

3

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

H203 ( MDM2 x MDMX )	Neoplasms More	Preclinical
Recombinant SARS-CoV-2 S-Trimer Vaccine (CHO Cell)(Binhui Biopharmaceutical) ( SARS-CoV-2 S protein )	COVID-19 More	Preclinical
Oncolytic Herpes Simplex Virus Type 2 ( GM-CSF )	Neoplasms More	Preclinical
CN114957491 ( CTNNB )	Neoplasms More	Discovery