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OBJECTSThis study compared the clinical efficacy and safety of anti-methicillin-resistant Staphylococcus aureus (MRSA) quinolones for treating acute bacterial skin and skin structure infections (ABSSSIs).METHODSPubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for relevant articles from inception to 21 July 2021. RCTs comparing the clinical efficacy and safety of anti-MRSA quinolones with other antibiotics for treating adult patients with ABSSSIs were included.RESULTSSix RCTs were included. A total of 1,264 and 1,307 participants received the anti-MRSA quinolone-based study group and the control group. In the study group receiving anti-MRSA quinolone-based treatment, 935, 246, and 83 patients received delafloxacin, levonadifloxacin, and acorafloxacin, respectively. No significant difference was observed in the clinical cure rate at test of cure between the study and control groups (OR, 1.08; 95% CI, 0.91-1.29; I² = 0%). In patients with MRSA-associated ABSSSIs, the clinical cure rate (OR, 1.09; 95% CI, 0.71-1.65; I² = 0%) and microbiological response rate (OR, 1.24; 95% CI, 0.48-3.21; I² = 0%) of anti-MRSA quinolones were similar to those of other antibiotics.CONCLUSIONSThe efficacy of anti-MRSA quinolone-based treatment is comparable to that of other anti-MRSA antibiotics for treating ABSSSIs.

01 May 2022·Pediatric Cardiology and Cardiac Surgery

ファロー四徴症修復術後患者の社会的自立状況と生活習慣の検討

Author: Chishaki, Hiroaki ; Nagata, Hazumu ; Chishaki, Akiko ; Shinbara, Ryoji ; Yamasaki, Keiko ; Tsutsui, Hiroyuki ; Sakamoto, Ichiro ; Sawatari, Hiroyuki ; Kang, Minjeong ; Yamamura, Kenichiro ; Tokunou, Tomotake

01 Nov 2021·Brain and DevelopmentQ4 · MEDICINE

Factors associated with high care burden of primary caregivers of children with medical complexity after completing a discharge-support program in a recovery center

Q4 · MEDICINE

Article

Author: Hamazaki, Takashi ; Funato, Masahisa ; Kondo, Masako ; Ito, Kazuya ; Fuyuki, Makiko ; Iijima, Yoshitaka ; Wada, Hiroshi ; Takemoto, Kiyoshi ; Shintaku, Haruo ; Yotani, Nobuyuki

INTRODUCTIONRecently, many seriously ill children requiring medical equipment are being recommended to transition from hospital to home care in Japan. Since 2011, our recovery center has provided a support program for the transfer process from hospital to home for ill children and their families. The purpose of this study was to evaluate the factors related to high care burden after completing the discharge-support program.METHODSA questionnaire-based cross-sectional study was conducted on all primary caregivers whose children received the program in our center and moved from hospital to home (30 children and 29 families) from May 2011 to May 2018. Fifteen children came from the neonatal intensive care unit. The questionnaire consisted of three parts: characteristics of children and families and life after the program; the Zarit Burden Interview (ZBI); and the Positive and Negative Affect Schedule (PANAS).RESULTSTwenty-three primary caregivers responded (79% response rate). All children received tracheostomy and 71% received home mechanical ventilation. Primary caregivers were all mothers. High ZBI score was not related to the severity and type of medical equipment. There were relationships between high ZBI score and following factors: 'unimproved relationship between patients and family members without primary caregivers' and 'additional medical equipment after discharge'. The result of PANAS showed that positive attitude was not different between those with high and low ZBI scores.CONCLUSIONIt is crucial to reach out to family members without a primary caregiver. Additional medical care/equipment after the program is related to the care burden of primary caregivers.

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