The efficacy of computerized cognitive rehabilitation on improving cognitive deficits and positive and negative symptoms of people diagnosed with schizophrenia

Start Date09 Jun 2024

Sponsor / Collaborator

University of Mohaghegh Ardabili

IRCT20200912048696N2

/ CompletedNot Applicable

The effect of NASM exercises on ground reaction forces, muscle electrical activity, and plantar pressures in people with piriformis syndrome, back pain, and foot peroneitis

Start Date05 Mar 2024

Sponsor / Collaborator

University of Mohaghegh Ardabili

100 Clinical Results associated with University of Mohaghegh Ardabili

0 Patents (Medical) associated with University of Mohaghegh Ardabili

7,177

Literatures (Medical) associated with University of Mohaghegh Ardabili

01 Feb 2025·Journal of Molecular Structure

Catalyst-free synthesis, antimicrobial evaluation, DFT, and molecular docking studies of novel spiro benzo[d]pyrrolo[2,1-b]thiazole-1,2′-indene hybrids

Author: Nassiri, Mahmoud ; Dehghani, Zahra ; Salehzadeh, Jaber

This research paper focuses on a novel, rapid, facile and highly efficient catalyst-free multi-component reaction of benzothiazole core 1, with 2-bromo-1,3-indandione 2 in the presence of acetylenic esters 3 for the synthesis of 1′,3′-dioxo-1′,3′-dihydro-3aH-spiro[benzo[d]pyrrolo[2,1-b]thiazole-1,2′-indene]-3-carboxylate derivatives 4a-i.This method was completed at ambient temperature in only 8 h with excellent yields, utilizing mild reaction conditions and cost-effective starting materials.Full confirmation of the synthesized compounds was obtained by a range of spectroscopic and anal. techniques, such as elemental anal., ¹HNMR, ¹³ CNMR, IR, and MS.The described structure of 4a was subjected to structural and electronic investigation, as well as ¹H and ¹³C chem. shifts, which were computed using the Gaussian 09 package and the B3LYP/6-311++G (d, p) level of d. functional theory (DFT) approach.The DFT study set out to allocate spectroscopic data in a way that made sense.The calculated DFT data are in close agreement with the exptl. data.Several bacterial strains were used to assess the produced compounds′ antibacterial properties.Certain substances demonstrated antibacterial activity that was either equivalent to or superior to the reference medications, gentamicin, and ciprofloxacin.Mol. docking research was also conducted on the chosen chems.According to the ADMET study of the synthesized mols., structures 4a, 4d and 4g show the most promise as drug-like mols.

01 Jan 2025·Gene

Association of adiponectin gene single nucleotide polymorphisms with environmental risk factors in type 2 diabetes mellitus: An updated evidence of haplotype-based analysis study

Article

Author: Siahkouhian, Marefat ; Ramezanzade, Raziye ; Mamashli, Elahe ; Davarnia, Behzad ; Jaspers, Richard T ; Iranparvar, Manouchehr ; Goulding, Richie P ; Skishahr, Farnaz Seifi

BACKGROUND AND AIMAdiponectin (ADIPOQ) gene is considered to be one of the promising players in deciphering the genetic bases of type 2 diabetes. This study investigated the associations between haplotype combinations of three single nucleotide polymorphisms (SNPs) of the ADIPOQ gene and two SNPs of the adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) genes with environmental risk factors for the prediction of T2DM disorder susceptibility in the Iranian population.METHODSThis case-control and cross-sectional study was conducted on 182 patients with T2DM and 155 healthy controls. Genotyping was performed using amplification refractory mutation system-PCR (ARMS-PCR) for rs17300539G/A, rs2241766T/G, and rs1501299G/T of the ADIPOQ gene, rs1342387C/T of the AdipoR1 gene, and rs10773989T/C of the AdipoR2 gene.RESULTSAll polymorphisms met the Hardy-Weinberg equilibrium (p> 0.05). The studied SNPs; rs17300539, rs2241766 of the ADIPOQ gene and rs10773989 of the AdipoR2 gene, were significantly associated with an increased risk of T2DM. Two-way ANOVA analysis indicated that GG carriers of rs2241766T/G had a significantly lower waist-to-hip ratio (P= 0.049) and body mass index (P= 0.011) and higher HbA1c (P= 0.048) compared to TT carriers, while TT genotype carriers of rs2241766T/G showed the higher plasma adiponectin concentration compared to TG and GG carriers (P= 0.009 and P= 0.013, respectively). CC carriers of rs10773989T/C displayed a significantly higher LDL level compared to the TT genotype carries (P= 0.036). Also plasma adiponectin concentrations were significantly lower in AA genotype carriers of rs17300539G/A compared to GG and GA genotypes carriers in the control group only (P= 0.005 and P= 0.016, respectively). According to Combined Haplotype ([rs17300539, rs2241766, rs1501299]/[rs17300539, rs2241766, rs1501299]) analysis, GTT-homozygote carriers displayed the highest plasma adiponectin concentration and in contrast, GGG/GTG, ATG/GTG, and GGG/GGG showed the lowest plasma adiponectin concentration in the controls (p> 0.05).CONCLUSIONThe adiponectin gene haplotype combinations were associated with plasma adiponectin concentration in healthy individuals. In T2DM, adiponectin genetic variants displayed less effect on adiponectin plasma concentration.

31 Dec 2024·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Utilizing developed multi-verse optimization algorithm for optimizing envelope design of residential structure

Author: Wan, Yunjie ; Ju, Yimeng ; Abdolhosseinzadeh, Sama

100 Deals associated with University of Mohaghegh Ardabili

100 Translational Medicine associated with University of Mohaghegh Ardabili

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