The electrostatic potential (V(r)), the average local ionization energy (I(r)), the relative hardness (ηrel), the electron affinity (EA), the ionization potential (IP), the electronegativity (χ), the hardness (η) and the electrophilicity (ω) were tested as theor. descriptors of the reported in-vitro antiviral activities against SARS-CoV-2 for seven different compounds with the same set of controlled variables: chloroquine, favipiravir, nafamostat, nitazoxanide, penciclovir, remdesivir, rivabirin, in order to obtain information about the electronic nature of the hosting sites in the virus. Results indicate that the hardness of the studied drugs correlates moderately well with the biol. activity, which gives some insights to infer in terms of the HSAB principle of Pearson, that the electrostatic interactions must predominate in the virus hosting sites and that these areas have low polarizability. When a multiple correlation anal. is performed, the correlation improves when the conceptual hardness (η), Vmin, and the mol. volume are considered, which suggests that the interaction of the mols. with the preferred hard hosting sites should be neg. affected by the volume of the selected drug and that Vmin contributes to the correlation.