Last update 01 Nov 2024

Public Higher Medical Professional School in Opole

Private Company

Last update 01 Nov 2024

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Translational Medicine

Overview

Clinical Trials associated with Public Higher Medical Professional School in Opole

IRCT20131001014844N1 / SuspendedNot Applicable

Clinical effect and postural stability analysis of Extracorporeal Shock Wave Therapy (ESWT) in the treatment of Low Back Pain (LBP): randomized controlled trial

Start Date09 Jun 2639

Sponsor / Collaborator

Public Higher Medical Professional School in Opole

ISRCTN28257448 / RecruitingNot Applicable

Assessment of selected skin parameters and quality of life after cosmetic procedures in people with acne vulgaris and oily skin

Start Date01 Oct 2020

Sponsor / Collaborator

Public Higher Medical Professional School in Opole

ISRCTN98261720 / CompletedNot Applicable

Impact of sonophoresis using a seboregulating ampoule on selected skin parameters and the quality of life acne patients

Start Date04 Feb 2020

Sponsor / Collaborator

Public Higher Medical Professional School in Opole

100 Clinical Results associated with Public Higher Medical Professional School in Opole

0 Patents (Medical) associated with Public Higher Medical Professional School in Opole

Literatures (Medical) associated with Public Higher Medical Professional School in Opole

25 Jul 2024·Journal of Medicinal Chemistry

Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity

Article

Author: Bendova, Katerina ; Shanzer, Abraham ; Aguiar, Mario ; Haas, Hubertus ; Caballero, Patricia ; Hubmann, Isabella ; Neuzilova, Barbora ; Gumienna-Kontecka, Elzbieta ; Petrik, Milos ; Mular, Andrzej ; Decristoforo, Clemens ; Kozłowski, Henryk

The pathogenic fungus Aspergillus fumigatus utilizes a cyclic ferrioxamine E (FOXE) siderophore to acquire iron from the host. Biomimetic FOXE analogues were labeled with gallium-68 for molecular imaging with PET. [⁶⁸Ga]Ga(III)-FOXE analogues were internalized in A. fumigatus cells via Sit1. Uptake of [⁶⁸Ga]Ga(III)-FOX 2-5, the most structurally alike analogue to FOXE, was high by both A. fumigatus and bacterial Staphylococcus aureus. However, altering the ring size provoked species-specific uptake between these two microbes: ring size shortening by one methylene unit (FOX 2-4) increased uptake by A. fumigatus compared to that by S. aureus, whereas lengthening the ring (FOX 2-6 and 3-5) had the opposite effect. These results were consistent both in vitro and in vivo, including PET imaging in infection models. Overall, this study provided valuable structural insights into the specificity of siderophore uptake and, for the first time, opened up ways for selective targeting and imaging of microbial pathogens by siderophore derivatization.

07 Dec 2020·Current Pharmaceutical BiotechnologyQ4 · MEDICINE

The Influence of Salinomycin on the Expression Profile of mRNAs Encoding Selected Caspases and MiRNAs Regulating their Expression in Endometrial Cancer Cell Line

Q4 · MEDICINE

Article

Author: Boroñ, Dariusz ; Januszyk, Krzysztof ; Januszyk, Piotr ; Oplawski, Marcin ; Grabarek, Beniamin O.

Background:Apoptosis could take place in the pathway dependent on death receptors or pathways dependent on mitochondria. In both, a key role is played by enzymes with protease activity, known as caspases.Aim: The aim of this study was to assess the variances in the expression pattern of caspase-dependent signaling pathways in the endometrial cancer cell line when treated with salinomycin. Additionally, the changes in the level of miRNA that potentially regulate these mRNAs were evaluated.Materials and Methods:Endometrial cancer cells were treated with 1 μM of salinomycin for 12, 24 and 48 hours. Untreated cells made up the control culture. The molecular analysis consisted of screening mRNA and miRNA microarray expression profiles of caspases, and the evaluation of the expression of caspases 3,8 and 9 by RTqPCR, also on the protein level.Results and Discussion:It was observed that 5 of the 14 differentiating mRNAs were commonly found for all incubation times of the cells and they corresponded with CASP3, CASP8, and CASP9 genes. The highest impact probability was determined between CASP3(up-regulated) and hsa- miR- 30d (FC -2.01), CASP8 (down-regulated) and hsa-miR-21 (FC +1.39) and between CASP9 (upregulated) and hsa-miR-1271 (FC +1.71).Conclusion:Salinomycin induces the apoptosis of endometrial cancer cells. The largest increase in activity was noted for caspases 3 and 9, while the expression of caspase 8 was decreased. Salinomycin causes a regulatory effect on the transcriptomes of mRNA and miRNA in in vitro endometrial cancer cells.

01 Dec 2020·Pomeranian Journal of Life Sciences

Radiopaque gauze migrating into the intestine – a case presentation

Author: Jabłecki, Jerzy ; Pupka, Dominika ; Szajerka, Tobiasz

AbstractDespite the meticulous monitoring of surgical material using the WHO Surgical Safety Checklist, gauze sponges and surgical instruments continue to be left inside patients after operations. It is an important issue for surgeons, operating room nurses and the entire medical team. Foreign bodies retained in the system may cause many disorders and result in potentially serious consequences for patients, including death. As well as this, further procedures are needed to remove them and treat any subsequent complications. Retained foreign bodies are rare, but intraluminal migration of the foreign body should be considered extraordinary. Very few cases have been reported so far. The authors believe that it is desirable to perform a wide range of diagnostic imaging in such cases.

100 Deals associated with Public Higher Medical Professional School in Opole

100 Translational Medicine associated with Public Higher Medical Professional School in Opole

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Public Higher Medical Professional School in Opole

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