[Translation] An open-label, multi-center, dose-escalation and expansion phase I clinical study evaluating the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of WTS-005 tablets in patients with advanced solid tumor cancer.
主要目的
1.评价WTS-005片在晚期实体瘤患者的安全性和耐受性。
2.确定最大耐受剂量(MTD)及II期推荐剂量(RP2D)。
次要目的 1.评价WTS-005片的初步抗肿瘤疗效。
2.评价WTS-005片在晚期实体瘤患者体内的药代动力学特征。
[Translation] main purpose
1. To evaluate the safety and tolerability of WTS-005 tablets in patients with advanced solid tumors.
2. Determine the maximum tolerated dose (MTD) and phase II recommended dose (RP2D).
Secondary objectives 1. To evaluate the preliminary anti-tumor efficacy of WTS-005 tablets.
2. To evaluate the pharmacokinetic characteristics of WTS-005 tablets in patients with advanced solid tumors.