Top 5 Target	Count

mTOR(Serine/threonine-protein kinase mTOR)	1
EGFR(Epidermal growth factor receptor erbB1)	1
EGFR T790M(Epidermal Growth Factor Receptor T790M)	1
CDK7(Cyclin-dependent kinase 7)	1

Drugs associated with University of Ulsan

rAAV2-sVEGFRv-1 (CuroGene Life Sciences/University of Ulsan)

Target

EGFR

Mechanism

EGFR modulators [+1]

Active Org.

University of Ulsan [+2]

Originator Org.

University of Ulsan

Active Indication

Age Related Macular Degeneration [+2]

Inactive Indication-

Drug Highest PhaseIND Application

First Approval Ctry. / Loc.-

First Approval Date-

rAAV2-shmTOR-GFP (CuroGene Life Sciences/University of Ulsan)

Target

mTOR

Mechanism

mTOR inhibitors

Active Org.

CdmoGen Co., Ltd. [+2]

Originator Org.

CdmoGen Co., Ltd.

Active Indication

Age Related Macular Degeneration [+2]

Inactive Indication-

Drug Highest PhaseIND Application

First Approval Ctry. / Loc.-

First Approval Date-

OBX1-012

Target

EGFR T790M

Mechanism

EGFR T790M inhibitors

Active Org.

University of Ulsan

Originator Org.

University of Ulsan

Active Indication

Non-Small Cell Lung Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date-

Clinical Trials associated with University of Ulsan

KCT0006775

/ RecruitingNot Applicable

Optimization of virtual reality for pain management of percutaneous transhepatic biliary drainage

Start Date09 Dec 2021

Sponsor / Collaborator

University of Ulsan

NCT04749888

/ Active, not recruitingNot ApplicableIIT

Impact of the Korea Early Childhood Home-visiting Intervention on Childhood Health and Development and Maternal Health: A Randomized Controlled Community Trial

Maternal and early childhood home visits have been proposed as an effective strategy to improve the health and development of disadvantaged children. In South Korea (hereafter, Korea), a maternal and early childhood home visit program has been implemented since 2013 in Seoul, and then was adopted in 2019 by the central government as a national policy for child health and development.
The Korea Early Childhood Home-visiting Intervention (KECHI) encompasses 25-29 home visits, group activities, and community service linkage by social workers from the prenatal period until the child reaches the age of 2 years; as such, it is a complex intervention involving various domains to address a wide range of outcomes. Each home visit is implemented based on the family's needs, and individualized interventions are provided to improve parenting and the home environment in order to promote children's health and development and maternal health.
This study is a randomized controlled community trial conducted in Korea to examine the impact of targeted home visits led by nurses in the prenatal and early childhood period on children's health and development and maternal health.
This study is a superiority trial with two parallel groups from pregnancy until the child reaches 2 years of age. Pregnant women with two or more risk factors will be recruited to participate in the study after they provide informed consent. Participants will then be randomly assigned to the intervention or control group with a 1:1 allocation through an independent web-based random allocation system. We expect a total of 800 families (400 families in each group) to be recruited. The intervention group will receive the KECHI program and the control group will receive existing maternal and child health services (usual care), but not multiple home visits by nurses. Both groups will receive gift cards of 30,000 Korean won (about 27 USD) for each round of surveys.
The intervention and control groups will be surveyed on the outcome variables of home environment, child development, breastfeeding, maternal health, child hospital visits due to injuries, and community service linkage at four home visits by trained research nurses at baseline and at 6 months, 12 months, and 24 months after birth. Telephone contact will also be made at 6 weeks and 18 months after birth for both groups. Outcome measurements will be performed by research nurses and data management will be conducted by statistical analysts. The analysis will be conducted for the intention-to-treat (ITT) and per-protocol (PP) groups, with an interim analysis of outcomes up to the 6-month follow-up. For the primary outcomes and certain secondary outcomes, subgroup analyses will be performed based on factors such as region, fertility status, number of risk factors, presence of depression, education level, etc.

Start Date27 Oct 2021

Sponsor / Collaborator

Seoul National University Hospital

[+6]

KCT0005817

/ CompletedNot Applicable

A Prospective Multicenter Randomized Controlled Study for the Evaluation of Efficacy and Safety of Balloon Eustachian Tuboplasty for Patients with Chronic Otitis Media due to Obstructive Tube Dysfunction

Start Date19 Jan 2021

Sponsor / Collaborator

University of Ulsan

100 Clinical Results associated with University of Ulsan

0 Patents (Medical) associated with University of Ulsan

24,350

Literatures (Medical) associated with University of Ulsan

01 Mar 2025·Carbohydrate Polymers

Polydopamine-integrated cellulose/graphene oxide monoliths: A versatile platform for efficient continuous-flow iodine capture and photothermal-enhanced reduction of Cr(VI)

Article

Author: Huang, Haiji ; Choi, Won Mook ; Lee, Myeong Joo ; Kim, Mun Ho ; Pradyasti, Astrini

The global challenge of wastewater contamination, especially from persistent pollutants like radioactive isotopes and heavy metals, demands innovative purification solutions. Radioactive iodine isotopes (¹³¹I and ¹²⁹I), stemming from nuclear activities, pose serious health risks due to their mobility, bioaccumulation, and ionizing radiation, particularly impacting thyroid health. Similarly, hexavalent chromium, Cr(VI), is highly toxic and persistent in water, linked to cancer and other severe health issues. Developing effective technologies for iodine capture and Cr(VI) reduction is therefore critical for public health and environmental protection. This study presents two distinct cellulose-based composite materials tailored for environmental remediation: cellulose/graphene oxide/polydopamine (cellulose/GO/PDA) monoliths for iodine capture and cellulose/graphene oxide/polydopamine/palladium nano-crystals (cellulose/GO/PDA/Pd) monoliths for the reduction of Cr(VI). PDA substantially enhances the adsorptive, catalytic and photothermal properties of monoliths. The monoliths demonstrated exceptional performance in both batch and continuous-flow reactor studies. Complete iodine removal was achieved within 15 s, while Cr(VI) was entirely reduced within 9 min under dark conditions and 5 min under photothermal conditions. Continuous-flow experiments showed sustained iodine adsorption of 92 % and Cr(VI) reduction of 81 % over 240 min. This research highlights the potential of PDA-enhanced cellulose-based composites as highly efficient and sustainable platforms for practical water remediation and environmental protection.

01 Mar 2025·Biomaterials

Direct extrusion of multifascicle prevascularized human skeletal muscle for volumetric muscle loss surgery

Article

Author: Phan, Huu Lam ; Nguyen, Chanh Trung ; Seo, Jongmo ; Le, Van Phu ; Koo, Kyo-In ; Lin, Chien-Chi ; Dang, Thao Thi ; Le, Thi Huong ; Back, Sung Hoon ; Koo, Kyo-in ; Duong, Van Thuy

Skeletal muscle is composed of multiple fascicles, which are parallel bundles of muscle fibers surrounded by connective tissues that contain blood vessels and nerves. Here, we fabricated multifascicle human skeletal muscle scaffolds that mimic the natural structure of human skeletal muscle bundles using a seven-barrel nozzle. For the core material to form the fascicle structure, human skeletal myoblasts were encapsulated in Matrigel with calcium chloride. Meanwhile, the shell that plays a role as the connective tissue, human fibroblasts and human umbilical vein endothelial cells within a mixture of porcine muscle decellularized extracellular matrix and sodium alginate at a 95:5 ratio was used. We assessed four types of extruded scaffolds monolithic-monoculture (Mo-M), monolithic-coculture (Mo-C), multifascicle-monoculture (Mu-M), and multifascicle-coculture (Mu-C) to determine the structural effect of muscle mimicking scaffold. The Mu-C scaffold outperformed other scaffolds in cell proliferation, differentiation, vascularization, mechanical properties, and functionality. In an in vivo mouse model of volumetric muscle loss, the Mu-C scaffold effectively regenerated the tibialis anterior muscle defect, demonstrating its potential for volumetric muscle transplantation. Our nozzle will be further used to produce other volumetric functional tissues, such as tendons and peripheral nerves.

01 Mar 2025·Applied Energy

Natural TPMS porous architectures for flow-field patterns to improve mass transport in high current density operations of proton exchange membrane fuel cells

Author: Lim, Ocktaeck ; Ho-Van, Phuc

Extending the ability to work at high current densities in proton-exchange membrane fuel cells (PEMFCs) is imperative for widespread adoption.Notably, multiple studies point to developing suitable flow-field patterns to mitigate mass-limited losses, yet there is no flow field that can effectively address the dual challenges of water flooding and fuel starvation in these operating conditions.In this study, we introduced a novel approach by integrating nature-inspired triply periodic minimal surface-based (TPMS) porous architectures into the PEMFC flow field.Our numerical results suggest that the G-ligament network (G²⁵_L-FF) is the most promising solutionPeriodic, non-tortuous pores effectively guide airflow toward gas diffusion layer (GDL), making G²⁵_L-FF achieve the lowest pressure drop among the proposed flow fields.MATLAB-based image processing reveals that G²⁵_L-FF keeps O₂ evenly distributed, leading to a c.d. of 1.91 A/cm² at a cell voltage of 0.4 V - 5 % greater than the state-of-the-art 3D fine-mesh flow field (3DFF) based on Toyota Mirai.An almost linear relationship in the polarization curve with no decline in the power d. was also observedAddnl., the G²⁵_L-FF shown the lowest water content in both vapor and liquid phases within the porous media but still achieved optimal membrane hydration, demonstrating its capability to prevent both drying and flooding.On the other hand, the I-ligament network improved reactant distribution uniformity over conventional parallel flow field (CPFF) due to its smaller local rib area, leading to an 8-15 % increase in c.d. in the ohmic loss region.Although it falls short in supporting forced convective gas penetration into the GDL, resulting in a c.d. of 1.7 A/cm² against 1.82 A/cm² for 3DFF, it nevertheless increased peak power d. by 18 % over CPFF.Our findings provide initial insight into the outstanding performance of the G-ligament network, confirming its potential to address mass-transport limitation, thereby extending the operational range of PEMFCs at high current densities and providing a new direction for next-generation flow-field designs.

News (Medical) associated with University of Ulsan

21 Jan 2021

·www.globenewswire.com

Global Crude Oil Refinery Maintenance Review 2020: Focus on Crude Distillation, Coking, Fluid Catalytic Cracking, Hydrocracker, Hydrotreater, and Reformer Units

Dublin, Jan. 18, 2021 (GLOBE NEWSWIRE) -- The "Global Crude Oil Refinery Maintenance Review, 2020 - Asia and North America Witness the Highest Maintenance in the Year" report has been added to ResearchAndMarkets.com's offering. In 2020, Asia had the highest refining capacity under maintenance (both planned and unplanned) globally with 11,524 mbd. In terms of highest capacity under planned maintenance, Asia led among the regions again with 11,319 mbd, while North America had the highest capacity under unplanned maintenance with 5,520 mbd. Among countries, the US, South Korea, and China were the top three countries globally in terms of refining capacity under maintenance (both planned and unplanned) for 2020. Ulsan refinery in South Korea, Ruwais in United Arab Emirates, and Yeosu in South Korea were the top three refineries in terms of refining capacity under maintenance (both planned and unplanned) in 2020. Scope Analysis of capacity under maintenance for crude distillation, coking, fluid catalytic cracking, hydrocracker, hydrotreater, and reformer units globally for 2020 Comparison of select refinery units under maintenance (planned, unplanned and both) by major regions for 2020 and 2019 Comparison of select refinery units under maintenance (planned, unplanned and both) by PADD regions in the US for both the years Comparison of select refinery units under maintenance (planned, unplanned and both) by operators for both the years Comparison of factors responsible for unplanned maintenance globally by region for 2020 and 2019 Reasons to Buy Keep abreast of major refinery units (crude distillation, coking, fluid catalytic cracking, hydrocracker, hydrotreater and reformer) undergoing maintenance globally Obtain information on region-wise maintenance globally for 2020 in comparison with 2019 Identify and compare PADD regions and operators with highest maintenance in both the quarters Facilitate decision making on the basis of strong refinery maintenance data Assess your competitor's refinery maintenance data Key Topics Covered: 1. Global Refinery Maintenance Review, 2020 1.1 Key Highlights 1.2 Major Outages in 2020 vis-a-vis 2019 1.3 Regional Maintenance Briefs 1.4 Factors Responsible for Unplanned Maintenance by Region, 2020 vis-a-vis 2019 2. Global Upcoming Planned Maintenance, 2021 3. Global Refinery Maintenance by Region 3.1 Global Refining Capacity under Maintenance by Region, 2020 vis-a-vis 2019 3.2 Global Coking Capacity under Maintenance by Region, 2020 vis-a-vis 2019 3.3 Global Fluid Catalytic Cracking (FCC) Capacity under Maintenance by Region, 2020 vis-a-vis 2019 3.4 Global Hydrocracker Capacity under Maintenance by Region, 2020 vis-a-vis 2019 3.5 Global Hydrotreater Capacity under Maintenance by Region, 2020 vis-a-vis 2019 3.6 Global Reformer Capacity under Maintenance by Region, 2020 vis-a-vis 2019 4. Refinery Maintenance by Petroleum Administration for Defense Districts (PADD) Regions in the US 4.1 Refining Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 4.2 Coking Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 4.3 FCC Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 4.4 Hydrocracker Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 4.5 Hydrotreater Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 4.6 Reformer Capacity under Maintenance by PADD Regions in the US, 2020 vis-a-vis 2019 5. Global Refinery Maintenance by Operator 5.1 Global Refining Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 5.2 Global Coking Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 5.3 Global FCC Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 5.4 Global Hydrocracker Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 5.5 Global Hydrotreater Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 5.6 Global Reformer Capacity under Maintenance by Operator, 2020 vis-a-vis 2019 For more information about this report visit Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research. CONTACT: ResearchAndMarkets.com Laura Wood, Senior Press Manager press@researchandmarkets.com For E.S.T Office Hours Call 1-917-300-0470 For U.S./CAN Toll Free Call 1-800-526-8630 For GMT Office Hours Call +353-1-416-8900

100 Deals associated with University of Ulsan

100 Translational Medicine associated with University of Ulsan

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Pipeline

Pipeline Snapshot as of 02 Feb 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

Other

Current Projects

Drug(Targets)	Indications	Global Highest Phase

QS1189 ( CDK7 )	Mantle-Cell Lymphoma More	Preclinical
rAAV2-sVEGFRv-1 (CuroGene Life Sciences/University of Ulsan) ( EGFR )	Choroidal Neovascularization More	Preclinical
rAAV2-shmTOR-GFP (CuroGene Life Sciences/University of Ulsan) ( mTOR )	Retinal Diseases More	Preclinical
OBX1-012 ( EGFR T790M )	Non-Small Cell Lung Cancer More	Preclinical
JDY-8112	Inflammation More	Pending

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