Clinical and Radiographic Evaluation of Lesion Sterilization With Triple Antibiotic Paste Versus Root Canal Treatment With Calcium Hydroxide-iodoform Paste in Mandibular Primary Molars Diagnosed With Necrotic Pulp or Irreversible Pulpitis

The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.

Start Date30 Apr 2025

Sponsor / Collaborator

Canakkale Onsekiz Mart University

NCT06771362

/ Not yet recruitingNot ApplicableIIT

Evaluation of ART Restorations Using Two Different Bulk-Fill Restorative Materials in Primary Molars With 12-month Follow-up According to Modified USPHS and Revised FDI Criteria

The aim of this clinical study is to evaluate the success of two different bulk-fill restorative materials applied to teeth restored with atraumatic treatment at 3, 6, and 12-month follow-ups. The research seeks to address the following questions:
Which bulk-fill restorative material is more effective in terms of clinical success? How does the clinical success of bulk-fill restorations change over time (3, 6, and 12 months)? How do the two materials compare in terms of functional, aesthetic, and biological outcomes? To what extent does the cavity size of teeth with interproximal caries, restored using atraumatic treatment, influence treatment success? In this study, asymptomatic teeth with aproximal caries in children aged 4-9 will be repaired using atraumatic treatment and assessed based on the Modified USPHS (United States Public Health Service) and Revised FDI (World Dental Federation) criteria.

Start Date30 Jan 2025

Sponsor / Collaborator

Canakkale Onsekiz Mart University

NCT06756399

/ Not yet recruitingNot Applicable

Relationship Between Sarcopenia and Peripheral and Respiratory Muscle Strength in Geriatric Individuals

Population aging is a significant global trend, with projections indicating that by 2050, 1 in 6 individuals worldwide will be over 65 years old, compared to 1 in 11 in 2019. In Turkey, the elderly population is expected to rise to 11.0% by 2025 and reach 25.6% by 2080. Sarcopenia, characterized by the progressive loss of skeletal muscle mass (SMM) and function due to aging, affects approximately 29% of older adults in community healthcare settings. It is associated with various pathophysiological processes, leading to negative health outcomes like falls and frailty.
The European Working Group on Sarcopenia in Older People (EWGSOP) established diagnostic criteria for sarcopenia based on muscle mass, strength, and physical performance in 2010, later revised in 2018 (EWGSOP2), emphasizing low muscle strength as the primary diagnostic criterion. The SARC-F questionnaire is recommended for confirming sarcopenia, with a score of ≥ 4 indicating the condition.
The concept of respiratory sarcopenia, introduced in 2021, refers to the loss of respiratory muscle mass and strength alongside general body sarcopenia, though measuring respiratory muscle mass can be complex. Respiratory muscle strength can be assessed through mouth pressure measurement, but a consensus on the methodology is still lacking.
Overall, there is insufficient research on the relationship between peripheral and respiratory muscle weakness and sarcopenia in the elderly. This study aims to explore this relationship further.

Start Date20 Jan 2025

Sponsor / Collaborator

Canakkale Onsekiz Mart University

100 Clinical Results associated with Canakkale Onsekiz Mart University

0 Patents (Medical) associated with Canakkale Onsekiz Mart University

8,807

Literatures (Medical) associated with Canakkale Onsekiz Mart University

01 Oct 2025·Computational Biology and Chemistry

Prediction of newly synthesized heparin mimic’s effects as heparanase inhibitor in cancer treatments via variational quantum neural networks

Article

Author: Sever, Meryem Rüveyda ; Kocabay, Samet ; Taşkın, Irmak İçen ; Şener, Ramazan ; Acar, Erdi ; Memiş, Samet

Cancer remains a leading global cause of death, primarily driven by the uncontrolled proliferation of abnormal cells. Malignant tumors, such as carcinomas, originate from unchecked epithelial cell growth and produce growth factors like FGF and VEGF, which promote angiogenesis and tumor progression through heparanase-mediated degradation of heparan-sulfate proteoglycans. Chitosan and its derivatives have shown promise in inhibiting tumor growth and metastasis. This study aims to investigate newly synthesized sulfated chitosan oligomers as heparin mimics to inhibit heparanase, evaluating their cytotoxic effects on SH-SY5Y, HCT116, A549, and MDA-MB-231 cancer cell lines. Moreover, it seeks to leverage a variational quantum neural network (VQNN) to predict and validate cytotoxicity outcomes, integrating quantum computing methods into evaluating novel anticancer compounds. The VQNN algorithm was applied to analyze the anticancer effects of sulfated chitosan oligomers. Cytotoxicity data from wet lab experiments validated the model's predictive performance. The VQNN model demonstrated strong predictive capabilities in evaluating anticancer compounds. Specifically, it achieved a mean absolute error (MAE) of 6.5844, indicating a similar trend to the experimental results. Additionally, the model obtained an R² value of 0.6020, reflecting a moderate level of correlation between predicted and observed outcomes. The results underscore the potential of integrating quantum-based machine learning models into cancer research. The VQNN effectively predicted experimental outcomes, showcasing its utility in assessing novel anticancer compounds. This approach could speed up drug discovery by streamlining the identification and optimization of therapeutic candidates. Furthermore, the findings support the ongoing development of quantum computing techniques for tackling complex biological challenges, contributing to innovative cancer treatment strategies that target tumor growth and angiogenesis.

01 Aug 2025·Colloids and Surfaces B: Biointerfaces

Tannic acid-based bio-MOFs with antibacterial and antioxidant properties acquiring non-hemolytic and non-cytotoxic characteristics

Article

Author: Demirci, Sahin ; Ari, Betul ; Guven, Olgun ; Can, Mehmet ; Suner, Selin S ; Sahiner, Mehtap ; Sahiner, Nurettin

Tannic acid (TA) based bio-metal phenolic networks (bio-MPNs) were prepared by using Cu(II), Zn(II), Bi(III), Ce(III), La(III), and Ti(IV) metal ions. TA-based bio-MPNs exhibited wedge-shaped pores between 16.4 and 25.8 nm pore size ranges. The higher gravimetric yield% was achieved for TA-Bi(III), and TA-Ti(IV) bio-MPNs with more than 90 %, and higher surface area was observed for TA-La(IIII) bio-MPNs as 56.2 m²/g with 17.3 nm average pore sizes. All TA-based MPNs are non-hemolytic with less than 5 % hemolysis ratio, whereas TA-based Bio-MPNs do not affect blood clotting with > 90 % blood clotting indexes except for TA-Cu(II) Bio-MPNs at 0.1 mg/mL concentration. Moreover, TA-Bi(III) and TA-Ce(III) Bio-MPNs were found to be safer materials showing no significant toxicity on L929 fibroblast cells at 100 μg/mL concentration, along with TA-based Bio-MPNs prepared with Cu(II), Zn(II), La(III), and Ti(IV) metal ions that could be safely used in in vivo applications at 1 μg/mL concentration. It has been proven by 2 different antioxidant tests that the prepared TA-based Bio-MPNs show antioxidant properties even if their TA-derived antioxidant properties decrease. Furthermore, all types of TA-based Bio-MPNs show great antimicrobial activity depending on the metal ion or microorganism types and the highest antibacterial/antifungal effect was determined for TA-Cu(II), and TA-Zn(II) Bio-MPNs with the lowest MBC/MFC values against Pseudomonas aeruginosa ATCC 10145, Bacillus subtilis ATCC 6633, and Candida albicans ATCC 10231.

01 Jul 2025·Psychology of Sport and Exercise

Psychological predictors of mental well-being in Judo athletes: Exploring the impacts of the coach-athlete relationship, social support, and psychological safety

Article

Author: Adiloğulları, İlhan ; Ender Şenel ; Küttel, Andreas ; Jowett, Sophia

Psychological predictors of mental well-being are crucial for improving athletes' mental health. Identifying and supporting the mental health of athletes is essential for a well-functional elite sports system. Previous research suggested that the quality of the coach-athlete relationship and a psychologically safe interpersonal environment can positively influence mental health. However, the interplay between these components and the role of social support has yet to be tested empirically. Therefore, the present study explored the impact of coach-athlete relationship quality and psychological safety on mental well-being through perceived social support within and outside sports. A sample of 323 national and international Turkish Judo athletes completed online questionnaires. Structural equation modelling revealed significant positive effects of the coach-athlete relationship on Judo athletes' mental well-being, mediated by social support and psychological safety. These findings demonstrate that the quality of the coach-athlete relationship can enhance perceived support in and outside sport, and perceived social support can contribute to experiencing a psychologically safe environment within which mental health issues are discussed, leading to an elevated well-being. The coach-athlete relationship alone was not a key factor for enhancing a psychologically safe environment related to athletes' mental health. However, the relationship athletes develop with their coach positively influences mental well-being via the perception of received social support and an enhanced psychologically safe environment specifically designed to allow athletes to discuss mental health issues. These results offer practical recommendations for coaches and professionals working in sports to improve athletes' mental well-being.

100 Deals associated with Canakkale Onsekiz Mart University

100 Translational Medicine associated with Canakkale Onsekiz Mart University

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