[Translation] An open-label, single-center, dose-escalation study of the safety, tolerability, and pharmacokinetics of CTB006 monotherapy in the treatment of advanced solid tumors
主要目的: 探索重组抗人DR5单克隆抗体注射液单药治疗晚期实体肿瘤的安全性与耐受性; 次要目的: 评估重组抗人DR5单克隆抗体注射液单药治疗晚期实体肿瘤的药代动力学特征; 初步评估重组抗人DR5单克隆抗体注射液治疗晚期实体肿瘤的抗肿瘤活性; 评估重组抗人DR5单克隆抗体注射液的免疫原性;
[Translation] Primary purpose: To explore the safety and tolerability of recombinant anti-human DR5 monoclonal antibody injection as a monotherapy for advanced solid tumors; Secondary purpose: To evaluate the pharmacokinetic characteristics of recombinant anti-human DR5 monoclonal antibody injection as a monotherapy for advanced solid tumors; To preliminarily evaluate the antitumor activity of recombinant anti-human DR5 monoclonal antibody injection in the treatment of advanced solid tumors; To evaluate the immunogenicity of recombinant anti-human DR5 monoclonal antibody injection;