Comparison of chronic groin pain in patients with or without mesh fixation with tacks undergoing Total Extra Peritoneal hernia repair for unilateral inguinal hernia : a randomized control trial - Nil

Start Date25 Nov 2024

Sponsor / Collaborator

Lady Hardinge Medical College

CTRI/2024/10/075615

/ Not yet recruitingNot ApplicableIIT

A randomised controlled trial to compare the use of fan retractor and Nathanson retractor for operative view score after liver retraction in laparoscopic bariatric surgery. - NIL

Start Date30 Oct 2024

Sponsor / Collaborator

Lady Hardinge Medical College

100 Clinical Results associated with Lady Hardinge Medical College

0 Patents (Medical) associated with Lady Hardinge Medical College

4,129

Literatures (Medical) associated with Lady Hardinge Medical College

01 Feb 2025·Gene

MALAT1 is important for facilitating HIV-1 latency reversal in latently infected monocytes

Article

Author: Singh, Aradhana ; Malik, Rupali ; Tandon, Ravi ; Kumar, Abhishek ; Verma, Anjali ; Gulati, Sameer ; Rai, Ankita ; Gaur, Ritu ; Nikita ; Dandu, Himanshu

Long non-coding RNAs (lncRNAs) are long RNA transcripts with length >200 nucleotides that do not encode proteins. They play a crucial role in regulating HIV-1 infection, yet their involvement in myeloid cells remains underexplored. Myeloid cells are susceptible to HIV infection and contribute substantially to the latent HIV reservoir. Therefore, disruption of latency within these reservoirs is crucial for achieving a definite cure. In this study, we aimed to ascertain the role of MALAT1 lncRNA in reversal of HIV-1 latency. Latently HIV-infected cell line, U1 was treated with SAHA, followed by qRT-PCR assays to confirm HIV-1 reactivation, and MALAT1 expression was assessed. The in vitro experiments revealed a significant increase in MALAT1 expression following latency reactivation and HIV-1 infection, while its knockdown using siRNA resulted in suppression of HIV transcription, which implies that MALAT1 play a significant role in facilitating the reversal of HIV-1 latency by promoting HIV transcription. Clinical samples were analysed to measure MALAT1 and pro-inflammatory cytokines expression. The elevated MALAT1 expression in treatment-naïve subjects compared to those on ART and HIV-negative controls suggests its association with HIV replication. Moreover, correlation analysis revealed a positive association between MALAT1 expression and pro-inflammatory cytokines, TNF-α and IP-10. To conclude, MALAT1 lncRNA emerged as a crucial facilitator of HIV-1 latency reversal in latently infected monocytes by inducing the expression of pro-inflammatory factors. These findings highlight that MALAT1 could potentially be explored as the therapeutic intervention to reactivate latent cells in monocytes.

08 Jan 2025·The American Journal of Tropical Medicine and Hygiene

Successful Management of Rhinofacial Conidiobolus coronatus Infection with Itraconazole Monotherapy

Article

Author: Bansal, Abhinav ; Sharath, Savitha ; Ahuja, Arvind ; Sinha, Surabhi

ABSTRACT.There are no standard guidelines on the management of Conidiobolus infections, and many antifungals have been used, either alone or in combination. Relapses are common even after successful management. Although localized, they can result in severe facial disfigurement and may rarely cause disseminated entomophthoromycosis, which can have fatal complications. We present a case of biopsy-proven conidiobolomycosis in a young immunocompetent male patient with progressive unilateral rhinofacial swelling who was successfully treated with itraconazole monotherapy and showed no relapse after 1 year of therapy.

01 Jan 2025·Indian Journal of Orthopaedics

Bone and Joint Involvement in Beta Thalassemic Patients: A Cross-sectional Study

Article

Author: Kakkar, Shruti ; Jain, Deepak ; Nayyar, Anisha ; Khosla, Nitish ; Selhi, Harpal Singh ; Selhi, Arshneet Kaur

PurposeThere is paucity of guidelines with inadequate data available about the extent and prevention of bone and joint disease in beta-thalassemic patients in Indian population. This study aims to determine bone and joint involvement in beta-thalassemic patients. It evaluates serum biochemical parameters of bone formation and resorption and correlates with the symptomatology in these patients. The study also determines their daily physical activity and find a correlation if any with bone mineral density.MethodsThe study was carried out on 40 regularly transfused beta thalassemic patients between 5 and 18 years of age under regular follow-up at our centre from June 2012 to June 2014. All patients were interviewed as per a well-structured proforma for symptoms relating to bone and joint disease as described by the patient/parents in past 1 year and physical activity by QAPACE questionnaire. Venous blood samples were drawn under aseptic conditions and used for estimation of biochemical parameters (calcium, phosphorus, alkaline phosphatase, vitamin D, parathyroid hormone and serum ferritin). Enrolled subjects were scanned for bone mineral density (BMD) at femur neck, trochanter and Ward's angle using dual-energy X-ray absorptiometry.ResultsA total of 40 patients were enrolled in the study (Male:Female = 80:20). Half the patients (n = 20) had symptoms pertaining to bone and joint disease. The most common symptom was leg pain (42.50%), followed by backache (22.50%). Asymptomatic patients had greater mean serum vitamin D as compared to the symptomatic patients (22.2 vs 15.08 ng/ml) (p = 0.225). Five patients were detected to have osteopenia, all above 10 years of age. The mean BMD in symptomatic patients at femur neck, trochanter and ward's angle was 0.781, 0.639 and 0.735 g/cm², respectively, as compared to 0.754, 0.635 and 0.722 g/cm² in asymptomatic patients. The difference was not statistically significant. Patients with low BMD had lower mean pre-transfusion Hb (< 9 g/dl) (p = 0.01). Eighty percent of osteopenic patients had sedentary lifestyle as compared to 44% of patients with normal BMD. Bone mineral density did not have any correlation with vitamin D levels, serum ferritin and type of chelation therapy.ConclusionPre-transfusion hemoglobin of more than 9 gm/dL has a protective role in maintaining good bone health and bone mineral density. Engaging thalassemia patients in physical activity has a positive effect on bone mineral density. Low vitamin D levels contribute to symptoms of bone and joint involvement in thalassemia and the same needs to be determined and supplemented.

100 Deals associated with Lady Hardinge Medical College

100 Translational Medicine associated with Lady Hardinge Medical College

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