Kunshan Double Crane Pharmaceutical Co. Ltd.

9-(2-Hydroxyethyl) adenine was prepared from ethylene carbonate and adenine with recycling of DMF solvent.

The synthesis of L-(+)-alaninol was described.L-Alanine, as starting material, was esterified with thionyl chloride and ethanol.The ester formed was reduced by zinc borohydride and hydrolyzed with sodium hydroxide to yield the title compound with 60% overall yield and 99% content.Zinc borohydride was prepared by the reaction of potassium borohydride and anhydrous zinc chloride.

1-(3-Chlorophenyl) piperazine was synthesized from 3-chloroaniline and bis(2-chloroethyl)amine hydrochloride, and reacted with 1-bromo-3-chloropropane to give 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine hydrochloride.The overall yield was 45.7%.