Delving into the Latest Updates on Medcin Instituto da Pele Ltda. with Synapse

Overview

This is a single-centre, single-blind, non-comparative clinical trial to assess the safety of the investigational product through clinical probability assessment.
Thirty-three female participants, aged between 18-45, will be required. Assessment of dermal (dermatological) and gynecological acceptance, in addition to pH measurements and vaginal force collection for microbiological analysis at the beginning and end of the study.

Start Date05 Nov 2023

Sponsor / Collaborator

BIOLAB SANUS Farmacêutica Ltda.

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100 Clinical Results associated with Medcin Instituto da Pele Ltda.

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0 Patents (Medical) associated with Medcin Instituto da Pele Ltda.

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2

Literatures (Medical) associated with Medcin Instituto da Pele Ltda.

01 Aug 2015·Anais Brasileiros de DermatologiaQ4 · MEDICINE

Physiological and lifestyle factors contributing to risk and severity of peri-orbital dark circles in the Brazilian population

Q4 · MEDICINE

ArticleOA

Author: Bombarda Júnior, Mário Sérgio ; Christopher, J ; Vanderover, Garrett ; Bueno, Juliana Regina ; Matsui, Mary S ; Viscomi, Bianca Lenci Inácio ; Schalka, Sérgio ; Bombarda, Patricia Camarano Pinto ; Fthenakis, Christina G.

BACKGROUNDPeri-orbital dark circles are a cosmetic concern worldwide, and have been attributed to hyperpigmentation from allergy or atopic dermatitis, blood stasis, structural shadowing effects, and a thin epidermis/dermis under the eye. It is of interest to better understand lifestyle and demographic risk factors and the relative impact of melanin, blood and epidermal/dermal factors on the severity of Peri-orbital dark circles.OBJECTIVETo compare by non-invasive imaging the impact of biological factors to a visual grading scale for Peri-orbital dark circles, and test the correlation of various demographic factors with Peri-orbital dark circles.METHODSSubjects completed a lifestyle and health survey, and Peri-orbital dark circles severity was evaluated using standardized photographs. Hyperspectral image analysis was used to assess the contributions of melanin, blood volume, degree of blood oxygen saturation, and dermal scattering.RESULTSFamily history was the most significant risk factor for Peri-orbital dark circles. The average age of onset was 24 years, and earlier onset correlated with higher severity scores. Asthma was significantly associated with Peri-orbital dark circles scores, but self-reported allergy was not. In this study, sleep was not correlated with Peri-orbital dark circles scores. Hyperspectral imaging indicated that melanin was the dominant correlate for Peri-orbital dark circles severity, while oxygen saturation was secondary. The difference between under-eye and cheek measurements for ΔL*and ΔE* were the most significant instrumental parameters correlated with visual assessment of Peri-orbital dark circles severity.CONCLUSIONAlthough typically associated with lack of sleep, risk of Peri-orbital dark circles is primarily hereditary. The main factors contributing to the appearance of Peri-orbital dark circles are melanin and (deoxygenated) blood.

Journal of Clinical & Experimental Dermatology Research

Injectable Polyethylene Glycol Gel as Dermal Filler: 01 Year Clinical and Ultrasound Follow-Up

Author: Addor, Flavia A. S. ; Neri, Simone R. Nogueira Guerra

Facial alterations that occur with aging are result of combined effects of soft tissue atrophy with loss of facial volume, gravitational factor and decrease of elastic tissue.In order to minimize these alterations, minimally invasive procedures such as cutaneous filling have been gaining space in clin. practice.In 2008, Scientech Corporation-Italia introduced hydrogel of polyethylene glycol (PEG) REMAKE as cutaneous filler.This prospective study was developed to prove the effectiveness, safety and durability over the 12 mo after the application of PEG hydrogel, commercialized under the name of REMAKE. 40 female volunteers were included, between 30 and 60 years, with signs of malar region volume loss between 2 and 3 (Raspaldo's classification) and Nasogenian furrow accentuation, with score between 2 and 3 (Day and collaborators' classification).No patient had carried out procedures of temporary filling for 1 yr or permanent filling at any time.Objective parameters always show the scale of the improvement and an evaluation was selected through ultrasound exams and surface scan for evaluation of size and depth of wrinkles improvement.Evaluations by the US were carried out for 30, 120 and 360 days of product use, in a pilot group of 18 patients randomly selected to measure the product in the application plan and numerically assess alterations of volume (absorption/migration).Its durability of up to 01 yr after application is proved when no significant reduction

100 Deals associated with Medcin Instituto da Pele Ltda.

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100 Translational Medicine associated with Medcin Instituto da Pele Ltda.

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