Objective This study compared the fatigue behavior of endodontic instruments manufactured with conventional NiTi alloy electropolishing, RaCe (FKG Dentaire, LaChauxdeFonds, Switzerland), with instruments manufactured with NiTi CM Wire subjected to thermomech. treatment, in the manufacturing process, HyFlex CM (Colténe Whaledent, Cuyahoga Falls, Ohio, USA), both with similar geometry and dimensions in order to determine the influence of the manufacturing process in the fatigue resistance. Methods The methodoly consisted of twenty HyFlex CM and RaCe instruments with D0 0.25 mm, taper 0.06 mm / mm, 25 mm length, both with triangular cross section. The fracture resistance was evaluated by static fatigue test, using a stainless artificial canal with 5mm of radius (86°), recording the time and calculating the number of cycles until fracture occurs (NCF). For statistical anal. the Student t test was used The fractured instruments surface was analyzed by SEM. Results The NCF was significantly higher for HyFlex CM instruments in comparison with RaCe files (P♂0.05) being 1336% more resistant to fatigue. The anal. of the fractured surface by SEM showed ductile-kind morphol. characteristics for both instruments and the absence of plastic deformation. Conclusion HyFlex CM instruments present higher values of NCF. Thus, it can be concluded that the thermal treatment to which these instruments with CM Wire alloy are submitted makes them more resistant to fracture than Race instruments manufactured with conventional NiTi alloy electropolishing.