Delving into the Latest Updates on Stellate Therapeutics SAS with Synapse

Overview

Tags

Nervous System Diseases

Endocrinology and Metabolic Disease

Other Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

No Data

Disease Domain	Count

Nervous System Diseases	2
Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	3

A review.In this perspective, we now suggest that this novel role for SETX provides an addnl. pathway by which transcriptional and gene expression defects caused by mutations in SETX can lead to neurol. disease.The perspective introduced the novel role of SETX (senataxin) for regulating autophagy, including autophagy and neurol. disease, AOA2, ALS4 and SETX, SETX is linked to autophagy, SETX and R loops, etc.

01 Jan 2015·Synthetic Biology

The Cellular Chassis as the Basis for New Functionalities: Shortcomings and Requirements

Author: Antoine Danchin

By default synthetic biology refers to construction of synthetic genetic programs. Yet, programs must be expressed within a machine, and the elusive but multipurpose “chassis” is usually taken for granted. The program replicates while the chassis reproduces, showing that maturation, ageing and senescence are core processes which must be taken into account in order to explore realistic outcomes. Functional analysis reveals the essential functions that we need to consider. Some are listed in the present chapter, with emphasis on the role of information recruitment. This is a built-in process of living organisms whose outcome is the production of an ever young progeny as a way to cope with ageing and senescence. Life innovates using Maxwell’s demons-like nanomachines. This is at odds with standard engineering practices, opening up new perspectives for synthetic biology.

The emergence of the first cells

Author: Danchin, Antoine

A review discusses prebiotic metabolism , following the emergence of nucleotides, with polyphosphates as energy store, nucleic acids begin as the substrates of metabolic reactions, before the emergence of nucleic acids as templates for the transfer of information, with the translation process at its core.It also discusses various scenarios to explain the origin of primary components (elementary biobricks), particularly basic amino acids, nucleotides, coenzymes, and lipids, which are required to allow the building up of compartmentalized cells.Subsequently, a scenario is proposed where populations of protocells displaying a general propensity to behave as phagocytes will evolve into the three domains of life as it is known today, namely Eukarya, Bacteria, and Archaea.

100 Deals associated with Stellate Therapeutics SAS

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100 Translational Medicine associated with Stellate Therapeutics SAS

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Pipeline

Pipeline Snapshot as of 06 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

3

1

Other

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

STL-301	Nervous System Diseases More	Discovery
STL-401	Behavioural disorders More	Discovery
STL-201	Parkinson Disease More	Discovery
STEL-101	Parkinson Disease More	Pending