Front Pharmaceutical PLC.

Healthy subjects were used as research subjects to compare the absorption rate and extent of the test preparation of flurbiprofen gel patch and the reference preparation of flurbiprofen gel patch in healthy subjects and evaluate the bioequivalence of the two preparations. The safety, skin reactivity and adhesion of the test preparation flurbiprofen gel patch and the reference preparation flurbiprofen gel patch in Chinese healthy subjects were observed.

Primary study objective: To evaluate the absorption rate and extent of leprocaine cream and EMLA in healthy male and female subjects, and to evaluate whether the two preparations are bioequivalent. Secondary study objective: To evaluate the safety of the test preparation leprocaine cream and the reference preparation EMLA in healthy subjects.

Healthy subjects were used as the research subjects, diclofenac diethylamine emulsion developed by Fuyuan Pharmaceutical Co., Ltd. was used as the test preparation, and diclofenac diethylamine emulsion (Voltaren) certified by GSK Consumer Healthcare Schweiz AG and produced by GSK Consumer Healthcare SARL was used as the reference preparation. The pharmacokinetics of the two preparations in healthy subjects were compared and the bioequivalence of the two preparations was evaluated. The safety of the test preparation diclofenac diethylamine emulsion and the reference preparation diclofenac diethylamine emulsion in healthy subjects was observed.