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Last update 03 Mar 2026
Virginia Wesleyan University
Last update 03 Mar 2026
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NCT07413406
A Randomized Controlled Trial of a Care Partner-Centered Structured Retrieval Practice Intervention for Dementia Caregiver Education and Well-Being
100 Clinical Results associated with Virginia Wesleyan University
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27 Jan 2026ACS Omega
Design of Nanomaterial-Based Sensors for Enhanced Halogen Bonding
Article
Author: Leopold, Michael C. ; Hughes, Lillian B. ; Parish, Carol A. ; Vinnikov, Arielle ; Kittredge, Kevin W. ; Bevc, Felix ; Sheppard, Charles W. ; Chuidian, Lucas A. ; Edelman, Ben H.
Halogen bonding is a highly directional, noncovalent, intermolecular interaction which has been harnessed for a variety of applications, including sensor design. A halogen bond (XB) is formed between a region of positive electrostatic potential on a halogen atom (X) and electron rich portions of target molecules. The strength of XB interactions relies on shorter XB bond distances and more linear R-X···B bond angles, which facilitate stronger, more negative binding energies. While prior studies have sought to maximize interactions, few have explored or experimentally demonstrated how geometries and bond angles can enhance XB interactions. Herein, fundamental studies are conducted at self-assembled monolayers (SAMs) and gold nanoparticle (Au-NP) interfaces that are functionalized to engage in XB interactions. Alkanethiolate-stabilized Au-NPs, known as monolayer-protected gold clusters (MPCs), were enhanced with XB-donor capability by incorporating specialized XB donor thiol ligands including halogen terminated perfluorinated straight chain and rigid perfluoro-aromatic amide ligandsboth of which were used within nanomaterial composite films of single-walled carbon nanotubes (SWCNTs) as a sensing interface in both solution and the gas phase. DFT and vapor studies targeting cyclohexanone (CH), a known byproduct of hard-to-detect, nonvolatile explosives (e.g., RDX), produced a sensing interface that achieved detection limits of CH (<10 ppm) that markedly outperform similar systems. The materials and methods presented in this study further demonstrate the potential of XB systems as a rapid and sensitive step toward developing field sensors for explosives.
23 Oct 2025JOURNAL OF BACTERIOLOGY
Characterization of two co-regulated response regulators in
Clostridioides difficile
Article
Author: Cooper, D. Kane ; Thomas, Cynthia G. ; Mehra, Anchal ; Palmer, Jack Riley ; Tamayo, Rita ; Williams, Caitlin Lee ; Harrison, Emily K. ; Garrett, Elizabeth M.
ABSTRACT:
As an obligate anaerobe,
Clostridioides difficile
grows
exclusively in the host intestinal tract, necessitating mechanisms to sense
and respond to the gut environment. The atypical signal transduction system
encoded by
cmrRST
includes two OmpR-family response
regulators, CmrR and CmrT. These regulators control multiple important
phenotypes in
C. difficile
, including cell chaining, colony
morphology, swimming motility, and biofilm formation. CmrR has a typical
receiver domain with key conserved residues for phosphotransfer and
conformational change, while CmrT is missing conserved residues and is
likely a pseudoreceiver. Here, we used multiple methods to investigate dimer
formation, including bacterial two-hybrid systems in both
Escherichia coli
and
C. difficile
and
pull-down assays in
E. coli
. We detected CmrR homodimers
and found that CmrR recognizes a specific DNA sequence found in multiple
places in the genome, including upstream of
cmrRST
. CmrT
formed homodimers in multiple assays, and mutation analysis of residues in
its unusual active site suggests multiple mutations are needed to maximally
reduce CmrT activity. Our data also suggest that CmrR and CmrT can form
heterodimers, though the biological relevance of CmrR-CmrT heterodimers
remains unclear. Our results suggest that CmrR and CmrT work together in
transcriptional responses to stimuli.
IMPORTANCE:
Two-component systems are nearly ubiquitous among bacteria and are one of
the primary ways that bacteria respond to their environment. Atypical
two-component proteins and systems are being identified in diverse
bacteria, and studying these proteins helps us to understand the
underlying mechanisms of these systems. CmrRST is an unusual
two-component system that regulates many important phenotypes in
Clostridioides difficile
. This work begins to
untangle the complex regulatory mechanisms by which CmrRST controls gene
expression and furthers our understanding of the fundamental biology of
C. difficile
.
02 Sep 2024Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
Teaching older adults to use retrieval practice improves their self-regulated learning
Article
Author: Babineau, Addison ; Tauber, Sarah K. ; Ariel, Robert
Retrieval practice can reduce associative memory deficits for older adults but they underutilize this potent learning tool during self-regulated learning. The current experiment investigated whether teaching older adults to use retrieval practice more can improve their self-regulated learning. Younger and older adults made decisions about when to study, how often to engage in retrieval practice, and when to stop learning a list of medication-side effect pairs. Some younger and older adults received instructions before learning that emphasized the mnemonic benefits of retrieval practice over restudying material and described how to schedule retrieval practice to learn to a goal criterion level. This minimal intervention was effective for improving both younger and older adults' associative memory. These data indicate that a simple strategy for improving older adults self-regulated learning is to provide them with instructions that teach them how to use criterion learning to schedule their retrieval practice for to-be learned material.
13 Sep 2022
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100 Deals associated with Virginia Wesleyan University
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100 Translational Medicine associated with Virginia Wesleyan University
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