A comparison on the effects of Rocuronium and Vecuronium on tracheal intubation and maintainence of anaesthesia among patients undergoing elective surgery

Start Date01 Nov 2012

Sponsor / Collaborator

Sree Gokulam Medical College & Research Foundation

CTRI/2018/05/014173

/ CompletedPhase 4

A RANDOMIZED CONTROLLED TRIAL ON THE EFFECT OF USING PRIMING PRINCIPLE ON THE INDUCTION DOSE REQUIREMENTS OF PROPOFOL AND HAEMODYNAMIC CHANGES OF STUDY SUBJECTS - PROPOPRIME

Start Date26 Sep 2012

Sponsor / Collaborator

Sree Gokulam Medical College & Research Foundation

100 Clinical Results associated with Sree Gokulam Medical College & Research Foundation

0 Patents (Medical) associated with Sree Gokulam Medical College & Research Foundation

Literatures (Medical) associated with Sree Gokulam Medical College & Research Foundation

01 Apr 2025·INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH

PREVALENCE OF VISUAL IMPAIRMENT AND PATTERN OF OCULAR MORBIDITY AMONG INMATES IN A SPECIAL CARE WARD FOR ELDERLY CITIZENS.

Author: Varghese, Vivek Oommen ; Veettil Chalil, Sibiliya Karupam ; Thampi, Bindu ; R S, Rekha

Background: Visual Impairment (VI) and blindness are strongly associated with aging and late life disability. A large proportion of this VI is avoidable. This study was done to estimate the prevalence of VI and pattern of ocular morbidity among inmates in a special care ward for elderly citizens in a tertiary care hospital Methods: A hospital-based cross-sectional study was conducted among 72 patients. A questionnaire including sociodemographic profile, systemic conditions and detailed ocular history was collected. Distant visual acuity was assessed and VI was graded according to WHO classification(2018)into mild(<6/12to6/18),moderate(<6/18to6/60), severe(<6/60to3/60) and blindness(<3/60).Anterior segment examination, intra ocular pressure(IOP)measurement, Dry eye disease(DED)evaluation and dilated fundus examination was done. Results: Mean age was70.7 years.66.7% were females. The prevalence of VI was83.3%, majority of them having moderate VI. The leading cause of VI was Cataract (81.9%)in all the categories of VI followed by Diabetic Retinopathy(DR)in moderate and severe VI and Age Related Macular Degeneration(ARMD)in mild VI.58.3% had only primary level of education. 87.5% of the patients belonged to a low socioeconomic status.38.9% had not been visited by their relatives in over an year.31.9% had their previous ocular examination over an year ago. Type 2 Diabetes Mellitus(T2DM)(66.7%), Dyslipidaemia(DLP)(31.9%), Systemic Hypertension(SHTN)(45.8%)and Heart disease(5.56%)were the comorbidities. 61.11% had DED, 29.2% had DR,36.1% had ARMD, 19.4% had Hypertensive Retinopathy(HTNR)and 2.8% had Glaucoma. Conclusions: Prevalence of VI was found to be 83.3%, majority being moderate category. Cataract was found to be the leading cause of ocular morbidity which is a treatable cause of VI. Educating elderly people and their caregivers about common eye conditions, importance of preventive measures and early treatment will help in preventing ocular morbidity.

01 Apr 2025·Journal of the Association of Physicians of India

Spectrum of Thyroid Disorders in Rheumatoid Arthritis

Article

Author: Pallivalappil, Shiji ; Kumar, Megha S ; Nair, Adarsh S

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory arthritis involving 0.5–1% of the global population. Coexistence of RA and thyroid dysfunction is now increasingly being recognized. This is due to the shared factors involved in the pathogenesis of RA and autoimmune thyroid disease. Thyroid disorder is an important amplifier of disease activity, thereby impairing the quality of life. Objectives: To study the prevalence and pattern of thyroid dysfunction in RA patients, to compare the disease activity among RA patients with thyroid dysfunction and those without thyroid dysfunction, and to study the possible association between severe RA and thyroid dysfunction. Methodology: A hospital-based analytical cross-sectional study was done in 165 RA patients attending the General Medicine and Rheumatology outpatient facilities of the Department of General Medicine, Government Medical College, Kozhikode, from January to December 2019. Study subjects were selected based on the inclusion and exclusion criteria. Relevant investigations were done, which included serum thyroid stimulating hormone (TSH), free thyroxine (free T4), free triiodothyronine (free T3), and anti-thyroid peroxidase antibody (anti-TPO) antibody levels. Data were analyzed using MS Excel and Statistical Package for the Social Sciences (SPSS) software. The prevalence and pattern of thyroid disorders in RA patients were assessed. The association of thyroid dysfunction with disease activity was tested. Results: The prevalence of thyroid dysfunction among RA patients was 38.2%. The most common thyroid disorder observed was subclinical hypothyroidism, which was seen in 33.3% (55) of the study population, followed by overt hypothyroidism in 3.6% (6) of patients. Both subclinical hyperthyroidism and clinical hyperthyroidism were found in only 0.6% of RA patients. There was a significant difference in mean age between RA patients with thyroid dysfunction and euthyroid patients (p-value = 0.001). No significant association was found between the duration of RA and thyroid dysfunction (p-value = 0.253). RA patients with thyroid dysfunction had elevated inflammatory markers compared to those with normal thyroid function. The prevalence of autoimmune thyroid disorder in RA patients is 24.8%. There was a significant association between disease activity and thyroid dysfunction (p-value = 0.001). Patients with thyroid disorders had severe disease compared to euthyroid patients. A significant positive correlation was noted between serum TSH and Disease Activity Score-28 (DAS-28) (Pearson coefficient = 0.768, p-value = 0.000), and between anti-TPO antibody and DAS-28 (Pearson coefficient = 0.794, p-value = 0.000). Conclusion: Thyroid dysfunction is prevalent in 38.2% of RA patients, with subclinical hypothyroidism being the most common thyroid disorder encountered. RA patients with thyroid dysfunction had higher disease activity than euthyroid patients. Hence, thyroid function tests should be a routine investigation in all RA patients, and if found abnormal, they should be treated appropriately.

01 Mar 2025·IJID Regions

Klebsiella pneumoniae urinary tract infection: A multicentric study highlights significant regional variations in antimicrobial susceptibility across India

Article

Author: Sultan, Asfia ; Mohan, Balvinder ; Jardani, Amina Al ; Gupta, Aarti ; Rajaibi, Arwa Al ; Khan, Fatima ; Zadjali, Razan Al ; Farooq, Shaika ; Meena, Suneeta ; Sen, Manodeep ; Ilanchezhiyan, Nainaraj ; Mamari, Azza Al ; Balkhair, Abdullah ; Kapoor, Pawan ; Gur, Renu ; Masters, Ken ; Jain, Mannu ; Poojary, Aruna ; Taneja, Neelam ; Kanungo, Reba ; Goyal, Nisha ; Thakuria, Bhaskar ; Siddiqui, Areena H ; Dutta, Sudip ; Princess, Isabella ; Rajendradas, Rugma ; Soman, Rajeev ; John, Keith H St ; Jitendranath, Ashish ; Al Malehi, Amal ; Jabri, Zaaima Al ; Rizvi, Meher ; Mohapatra, Sarita ; Langford, Bradley ; Sami, Hiba ; Agarwal, Jyotsna ; Singh, Narendra Pal ; Khan, Maria ; Singh, Sarman ; Malhotra, Shalini ; Tahir, Hatim El ; Devi, Sheela ; Yamunadevi, Vellore Ramanathan ; Singh, Sanjeev ; Sardana, Raman

ObjectivesKnowledge of local antibiotic susceptibility rates is essential to strengthen antimicrobial stewardship programs. DASH to Protect Antibiotics (https://dashuti.com/), promotes the dissemination of focused local antibiograms in community urinary tract infection (UTI). This study mapped the susceptibility profile of Klebsiella pneumoniae from 18 Indian centers.MethodsThe centers spanned nine Indian States and three Union Territories. Urinary K. pneumoniae antibiograms from the outpatient clinic were collated and analyzed. Standardization was achieved through online training. For epidemiological purposes, five centers tested fosfomycin.ResultsOverall, low susceptibility (<60%) was observed for the standard oral antibiotics prescribed for cystitis: co-trimoxazole, 54% (36-68%); ciprofloxacin, 52% (29-55%); amoxicillin-clavulanic acid, 46%, (35-82%); nitrofurantoin, 39% (19-78%); and cefuroxime, 30% (15-62%). The rates for third- and fourth-generation cephalosporins were 49% (45-52%) and 60% (36-76%), respectively. Extended-spectrum beta-lactamases ranged from 36-61% in India. Piperacillin-tazobactam 74% (65-87%), amikacin 76% (45-91%), and meropenem 81% (61-87%) exhibited higher activity. Fosfomycin was the most active antimicrobial, with 89% (92-97%) susceptibility. K. pneumoniae susceptibility was directly linked to geographic region, log gross domestic product (P <0.001), and humidity, and low and high temperatures (P <0.05).ConclusionsOral treatment options for K. pneumoniae cystitis are rapidly decreasing. Northern and southern India showed significant differences in antimicrobial susceptibility, highlighting the importance of local antibiograms for promoting antimicrobial stewardship. For uncomplicated cystitis, co-trimoxazole (54%) may be the empirical choice. Good susceptibility to fosfomycin was observed (89%). The empirical use of fluoroquinolones, cephalosporins, and amoxicillin-clavulanic acid has been discouraged. Piperacillin-tazobactam and aminoglycosides are carbapenem-sparing agents.

100 Deals associated with Sree Gokulam Medical College & Research Foundation

100 Translational Medicine associated with Sree Gokulam Medical College & Research Foundation

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