[Translation] An open-label Phase Ib study to evaluate the safety, tolerability, preliminary efficacy, and PK/PD characteristics of ORIC-1940 in Chinese patients with previously treated hemophagocytic lymphohistiocytosis
1.评价ORIC-1940在中国噬血细胞性淋巴组织细胞增多症(hemophagocytic lymphohistiocytosis, HLH)经治患者中的安全性和耐受性。
2.评价ORIC-1940在中国HLH经治患者中的初步疗效,确定II期推荐剂量(recommended phase 2 dose, RP2D)
3.评价ORIC-1940在中国HLH经治患者中的PK/PD特征
[Translation] 1. Evaluate the safety and tolerability of ORIC-1940 in Chinese patients with hemophagocytic lymphohistiocytosis (HLH) who have been treated.
2. Evaluate the preliminary efficacy of ORIC-1940 in Chinese patients with HLH who have been treated and determine the recommended phase 2 dose (RP2D)
3. Evaluate the PK/PD characteristics of ORIC-1940 in Chinese patients with HLH who have been treated