Comparison of the effect of two simulation methods on the mannequin and the escape room on team performance and self-efficacy understanding of nursing students of the two and three semester regarding the evaluation of cardiopulmonary resuscitation training.

Start Date06 Apr 2024

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Zabol University of Medical Sciences

100 Clinical Results associated with Zabol University of Medical Sciences

0 Patents (Medical) associated with Zabol University of Medical Sciences

1,908

Literatures (Medical) associated with Zabol University of Medical Sciences

01 Dec 2024·Molecular Biology Reports

Interaction of estradiol and renin–angiotensin system with microRNAs-21 and -29 in renal fibrosis: focus on TGF-β/smad signaling pathway

Review

Author: Kazeminia, Sara ; Saberi, Shadan ; Rajizadeh, Mohammad Amin ; Shahraki, Sarieh ; Rajabi, Soodeh ; Askaripour, Majid ; Najafipour, Hamid

Kidney fibrosis is one of the complications of chronic kidney disease (CKD (and contributes to end-stage renal disease which requires dialysis and kidney transplantation. Several signaling pathways such as renin-angiotensin system (RAS), microRNAs (miRNAs) and transforming growth factor-β1 (TGF-β1)/Smad have a prominent role in pathophysiology and progression of renal fibrosis. Activation of classical RAS, the elevation of angiotensin II (Ang II) production and overexpression of AT1R, develop renal fibrosis via TGF-β/Smad pathway. While the non-classical RAS arm, Ang 1-7/AT2R, MasR reveals an anti-fibrotic effect via antagonizing Ang II. This review focused on studies illustrating the interaction of RAS with sexual female hormone estradiol and miRNAs in the progression of renal fibrosis with more emphasis on the TGF-β signaling pathway. MiRNAs, especially miRNA-21 and miRNA-29 showed regulatory effects in renal fibrosis. Also, 17β-estradiol (E2) is a renoprotective hormone that improved renal fibrosis. Beneficial effects of ACE inhibitors and ARBs are reported in the prevention of renal fibrosis in patients. Future studies are also merited to delineate the new therapy strategies such as miRNAs targeting, combination therapy of E2 or HRT, ACEis, and ARBs with miRNAs mimics and antagomirs in CKD to provide a new therapeutic approach for kidney patients.

01 Dec 2024·Analytical Methods in Environmental Chemistry Journal

Removal of polypropylene nanoplastics from aqueous solution by biochar derived from Date palm fibers: Kinetics and isotherms studies

Author: Khodadadi, Batool Rezaei Kahkha Maryam ; Zhaleh, Mahdi Rezaei Kahkha ; Faghihi-Zarandi, Mohsen ; Kahkha, Mohammad Reza Rezaei

In this work, activated carbon (AC) derived from powder of date palm fibers (DPF) was examined as an adsorbent for removing polypropylene nanoplastics (PPNPs) from aqueous solutions. The adsorbent was characterized using XRD, FT-IR, and SEM analyses. Affecting parameters on removal efficiency in a batch reactor, such as contact time, concentration of PPNPs and amount of adsorbent, were evaluated and optimized. Equilibrium and kinetic studies are performed to understand adsorption mechanisms. In the batch system, 30 mL of polypropylene suspension (5-40 mgL-1) was added to Erlenmeyer flask. First, different amounts of AC adsorbent were added to the container, then microplastic was added to the reactor. The mixture was shaken on a shaker for four hours at 25oC. The flask was removed from the shaker, the concentration of PPNPs in the supernatant was measured, and a settling time of 30 min was obtained. A control suspension system without PPNPs nanoplastics (with biochar and without PPNPs) was also performed to evaluate carbon particle interference by turbidity measurements. Our results showed that kinetic data were consistent with the pseudo-second-order kinetic model. Equilibrium data for the adsorption of PPNPs on biochar represented by the Langmuir isotherm model is better than the Freundlich isotherm model.

11 Sep 2024·Cell journal

Mac-1 Alongside Platelet-Monocyte Aggregates as Potential Markers in Acute Coronary Syndrome: A Case-Control Study.

Article

Author: Shahraki, Hojat ; Olazadeh, Keyvan ; Gheydari, Mohammad Esmail ; Bashash, Davood ; Ghorbani, Mohammad ; Sargazi-Aval, Omolbanin ; Mohammadi, Mohammad Hossein ; Amiri, Vahid ; Hamidpour, Mohsen ; Mirsattari, Dariush

OBJECTIVECardiovascular diseases (CVDs) are the leading cause of death worldwide, with atherosclerosis serving as a primary factor in their development. Platelets, leukocytes, and their interactions play a crucial role in initiating and amplifying atherosclerosis. This study aims to evaluate the levels of platelet-monocyte aggregates (PMA) and specific integrins involved in leukocyte recruitment, including macrophage-1 antigen (Mac-1) and lymphocyte functionassociated antigen-1 (Lfa-1), in patients with acute coronary syndrome (ACS).MATERIALS AND METHODSIn this case-control study, thirty-two subjects with ACS and 30 healthy individuals participated. It aimed to evaluate PMA expression and the median fluorescence intensity (MFI) of Mac-1 and Lfa-1 using flow cytometry. Dot plots and Pearson correlation coefficient were employed to examine the relationship between PMA, Mac-1, and Lfa-1. Multilevel model analysis was used to explore the effects and relationships of various parameters, including Mac-1 and Lfa-1, on PMA. Finally, receiver operating characteristic (ROC) curves were utilized to assess the diagnostic accuracy of PMA, Mac-1, and Lfa-1 markers.RESULTSIt was observed that patients had higher PMA levels compared to the control group (58.99 ± 16.27 vs. 29.99 ± 4.19 in controls, P<0.001), which correlated with PLT (ρ=0.512, P=0.035). Additionally, CD18 and CD11b expression on monocytes were significantly elevated in patients (P<0.001) and were positively associated with PMA (β=19.09, P<0.001; β=6.90, P=0.022), but no significant relationship between CD11a and PMA was observed (β=5.06, P=0.315). PMA and Mac-1 were identified as better markers for differentiating patients from healthy individuals. (respectively, AUC=0.94, Sensitivity= 0.84, specificity=0.98; AUC=0.84, Sensitivity= 0.93, specificity=0.70).CONCLUSIONThe study results indicated an increase in both Mac-1 and PMA levels in patients with ACS. Additionally, the significant association observed between Mac-1 and PMA in the patient group suggests a potential relationship between these markers and ACS.

100 Deals associated with Zabol University of Medical Sciences

100 Translational Medicine associated with Zabol University of Medical Sciences

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