ABX advanced biochemical compounds GmbH

TEWKSBURY, MA / ACCESSWIRE / April 25, 2024 / Cambridge Isotope Laboratories, Inc. (CIL) has acquired an additional 14.8 acres of land at its Cambridge Isotope Separations (CIS) Xenia, Ohio location. Mike Steiger, Vice President of Engineering and Project Execution for CIL, stated that the new land purchase will ensure easier access to utilities for future expansion. Cambridge Isotope Separations This newly acquired land is situated to the west of the 20 acres purchased in 2017, which is currently the site of the North Star expansion project. This recently completed project will greatly increase 13C production and is in the startup phase. North Star is the largest 13C separation facility ever built in the world and will significantly increase CIL's capacity ensuring customer reliability for this stable isotope. The land acquired provides the business flexibility to expand in the future as the demand continues to grow worldwide in all applications. "This investment shows CIL's commitment to innovation and growth for our customers," said CEO Cliff Caldwell. "CIL works closely with our diverse and global customers to develop and commercialize exciting, high-value applications for isotopically labeled compounds. As these applications commercialize, our customers rely on CIL's ability to scale our chemistry quickly and reliably. This land acquisition assures we have the space to continue meeting their expectations and enable these technology advancements." The CIS facility has the world's largest 13C separation facility, is one of the world's largest 18O isotope-separation facilities and houses the largest commercial D2O re-enrichment columns in the world. Stable isotopes, particularly deuterium, have seen an increase in commercial-scale applications in the last few decades. These applications include pharmaceuticals, semiconductors, flat panel displays, and other high-technology fields. CIL has a three-year supply contract with one Canadian source for D2O, as well as three other sources, and holds an average of an 18-24-month supply in four of CIL locations to ensure the most reliable supply. About Cambridge Isotope Laboratories, Inc. CIL is the world's largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL subsidiary ABX in Dresden, Germany, is active in the development and commercialization of radio isotopic-labeled compounds for the diagnosis and treatment of cancers. CIL is an operating business owned by Otsuka Pharmaceutical. The CIL business consists of two facilities in the Boston, Massachusetts, area; a large isotope-enrichment production plant in Xenia, Ohio; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France. For more information on CIL, visit isotope.com. Contact Information Crissy Krisko crissyk@isotope.com 1.978.269.1930 SOURCE: Cambridge Isotope Laboratories, Inc. View the original press release on newswire.com.

New name reflects the company's pipeline of paired fluorine-18 PET diagnostics and radioligand therapies to find and treat cancer, led by a GRPR-targeting program for prostate cancer THE WOODLANDS, Texas--(BUSINESS WIRE)-- Fuzionaire Diagnostics, Inc. announced today that it has changed its name to Fuzionaire Theranostics, Inc. (“Fuzionaire Tx”). Originally directed to make diagnostic radiopharmaceuticals for PET scans, the company's HetSiFA® library has become a powerful theranostics platform that can also make radioligand therapies. HetSiFAs, or heteroaromatic silicon-fluoride acceptors, are modular radiolabeling moieties that enable rapid prototyping of peptide-based theranostics and the rapid manufacturing of fluorine-18 (18F) PET companions at large scale. HetSiFA-based radioligand therapies use leading alpha- and beta-emitting radionuclides. The HetSiFA® platform creates chemically identical diagnostic and therapeutic companions, a feature that enables a personalized therapeutic dose for each cancer patient. The name change marks a milestone in the company's growth plan and reflects a developing theranostic pipeline in oncology. Preclinical Oncology Pipeline Beginning With GRPR-Positive Prostate Cancer The company's first theranostic development program aims to improve the care of patients with metastatic prostate cancer by targeting the gastrin-releasing peptide receptor (GRPR) with a chemically identical and scalable 18F/ lutetium-177 (177Lu) theranostic pair. GRPR has emerged as a promising and validated target for prostate cancer to complement the widely utilized target prostate-specific membrane antigen (PSMA). In recent years, several PSMA-targeting radiopharmaceuticals have become available to patients worldwide. Novartis's PSMA-targeting radioligand therapy Pluvicto®, Lantheus's 18F PET imaging agent Pylarify®, Blue Earth Diagnostics' 18F PET imaging agent Posluma®, and ABX's PET imaging agent 18F-PSMA-1007 have been approved by regulatory agencies. Like Pylarify, Posluma, and 18F-PSMA-1007, Fuzionaire Tx's HetSiFA-based PET diagnostics use the nuclide 18F, which offers superior availability, production scalability, and image resolution as compared to gallium-68 (68Ga), often used in theranostics. Like Posluma, Fuzionaire Tx's HetSiFA-based radiopharmaceuticals are enabled by silicon. Posluma is the first drug approved by the FDA with a silicon-fluoride acceptor (SiFA) moiety. Fuzionaire Tx's patented HetSiFAs share the manufacturing advantages of SiFAs but with additional features, including an ability to create a more comprehensive array of theranostic candidates with different physicochemical and labeling properties. HetSiFAs are protected by a portfolio of issued and pending patents covering HetSiFAs and HetSiFA-containing candidates and the underlying silicon chemistry. In the context of the growth of PSMA radiopharmaceuticals and recent evidence that not all patients can benefit from them, GRPR has emerged as the most promising target to complement PSMA. The success of 18F/177Lu theranostics targeting PSMA underscores the need for an 18F/177Lu theranostic targeting GRPR. In this context, Fuzionaire Tx’s lead program targeting GRPR could occupy a key space in the portfolio of radiopharmaceuticals for prostate cancer. Additional Programs and Possibilities With origins in Robert Grubbs' lab at Caltech and the Crump Institute for Molecular Imaging at UCLA, the company's programs are advancing through a multi-party collaboration with McGill University, McMaster University, and Montreal-based contract research organization Paraza Pharma. The company is also advancing its programs in consultation with Prof. Mathias Schreckenberger, Director of the Nuclear Medicine Department at the University Medical Center Mainz in Germany, and the radiopharmaceutical contract development and manufacturing organization AtomVie Global Radiopharma Inc. The company's pipeline can expand further. The modularity of the HetSiFA platform enables the company to expand its pipeline rapidly with existing collaborators and new partners. In addition to the GRPR program, the company has discovery-stage programs for lung cancer and PSMA/GRPR-positive prostate cancer. Initial preclinical data from the GRPR program will be presented by Alexey Kostikov, PhD, Associate Professor at McGill University, at the American Chemical Society Fall Conference in August 2023. “We are motivated to continue to innovate in how we collaborate with new partners to expand the use of HetSiFAs and the ecosystem supporting these important new labeling moieties, and to advance our GRPR and other programs through clinical trials,” said Nick Slavin, CEO of Fuzionaire Tx. “By doing so, we can create new ways to treat cancer and make new theranostic medicines more accessible.” About Fuzionaire Theranostics Fuzionaire Theranostics is a radiopharmaceutical company on a mission to make theranostic treatments more accessible to people with cancer. With origins in Nobel laureate Robert Grubbs' lab at Caltech, the company's patented HetSiFA® platform offers manufacturing advantages in a clinical setting and enables a personalized therapeutic dose for each cancer patient. Current development plans address pressing clinical needs in prostate and lung cancer. For more, visit us at:

DUBLIN, Sept. 5, 2022 /PRNewswire/ -- The "Prostate Cancer Nuclear Medicine Diagnostics Market Forecast to 2028 - COVID-19 Impact and Global Analysis By Type, PET Product, and End User" report has been added to ResearchAndMarkets.com's offering. The global prostate cancer nuclear medicine diagnostics market is expected to grow from US$ 720.12 million in 2022 to US$ 1,315.66 million by 2028. It is estimated to grow at a CAGR of 10.6% from 2022 to 2028. Prostate cancer affects the prostate glands in males. Prostate cancer is common cancer following skin cancer in males. Common determinants responsible for prostate cancer are family history, old age, and race. Nuclear medicine is imaging that needs radioactive materials. It is a helpful method to identify and treat prostate cancer and helps radiologists conclude the stage of cancer. In terms of occurrence, prostate cancer (PCa) is the fourth most common cancer across the US. The rising incidences of prostate cancer in the country led to the increased use of nuclear medicines for its treatment. This cancer is more likely to grow in older adults. Thus, the rising cases of prostate cancer offer substantial growth opportunities for the prostate cancer nuclear medicine diagnostics market during the forecast period. Based on type, the prostate cancer nuclear medicine diagnostics market is bifurcated into SPECT and PET. The PET segment held the largest share of the market in 2021 and is anticipated to register the highest CAGR during the forecast period. A positron Emission Tomography (PET) scan is usually the most effective way to restage recurrent prostate cancer. After prostate cancer treatment, PET scanning may be used to determine the effectiveness of the treatment and is now commonly being used to detect biochemically recurrent prostate cancer for restaging. Rising research activities for developing novel imaging agents to improve prostate cancer detection and the development of novel imaging agents to improve prostate cancer detection are key factors driving the growth of nuclear medicine diagnostics. Researchers are conducting several studies to introduce new diagnostic agents for PET with higher efficiency than the existing agents. For instance, in March 2018, a study in The Journal of Nuclear Medicine demonstrated a novel PET agent named Copper-64 Chloride (64CuCl2) to detect prostate cancer. This new imaging agent exhibited a higher detection rate when compared with Fluorine-18-Choline (18F-choline). The adoption of PET as a diagnostic tool is significantly increasing, as it offers higher accuracy to that other diagnostic techniques. Accuracy in diagnosis has a direct impact on decision-making and treatment monitoring processes. Increasing demand for these diagnostic procedures is expected to fuel the growth of the prostate cancer nuclear medicine diagnostics market during the forecast period. Reimbursement policies is expected to further fuel the development of nuclear medicine diagnostics. Several programs such as Medicaid, Medicare, and the Health Insurance programs in the US are expected to create growth opportunities for the market players. For instance, the Centers for Medicare & Medicaid Services (CMS) covers PET services through National Coverage Determination (NCD) which includes tracers necessary for the diagnosis of prostate cancer. Therefore, due to the factors mentioned above, PET is expected to hold the largest market share. Key Market Dynamics Market Drivers Rising Prevalence of Prostate Cancer Surging Demand for Early and Precise Diagnosis of Prostate Cancer Market Restraints High Cost Related to the Prostate Cancer Diagnostics and Treatment Market Opportunities Growing Use of Radiopharmaceuticals in Prostate Cancer Future Trends Increasing Research Activities for Development of Innovative Imaging Agents Company Profiles Blue Earth Diagnostics Limited ImaginAB Curium Jubilant Radiopharma NCM-USA LLC ABX Advanced Biochemical Compounds GmbH Telix Pharmaceuticals Ltd. Novartis AG Theragonostics Lantheus Medical Imaging Inc. For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets