Author: Morgan, Juliet ; Aleksic, Milos ; Ternette, Nicola ; Sparrow, Emma ; Cundell, Michael ; Paes, Wayne ; Shiers, Jason J. ; Anderton, Kate ; Pinggera, Michael P. ; Sette, Jessica ; Joyce, Peter I. ; Ribeiro, Ana ; Quibell, Martin ; Leishman, Andrew

AbstractImmune checkpoint inhibitors (ICI) have changed the cancer treatment paradigm, yet significant unmet need remains. Clinical data shows that increasing antigen presentation diversity, genomic instability, tumor mutational burden and HLA diversity, as well as preventing permanent exhaustion of pre-existing cytotoxic T cells, caused by chronic cancer antigen stimulation, are all factors that improve clinical response to ICI. Additionally, increasing presentation of cancer-specific target peptides on cancer cells will enhance T cell receptor (TCR)-mediated therapeutics such as ImmTACs or TCR-Engineered T cells. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides loaded into classical and non-classical MHC Class I. In cancer, knockout or inhibition of ERAP1 changes a proportion of the antigen repertoire, generating and upregulating cancer antigens. This leads to the activation of de novo anti-tumor T cell responses, causing tumor growth inhibition and bypassing T cell exhaustion. We report the preclinical development, characterization and mechanistic analysis of the first-in-class ERAP1 inhibitor, GRWD5769. Extensive analysis of the immunopeptidomes of diverse cancer cell lines robustly showed that GRWD5769 modulates the cancer-related antigen repertoire across genotypes and cancer-type backgrounds. Novel or upregulated neoantigens generated by ERAP1 inhibition are conserved across cancer cell types and genetic backgrounds. ERAP1 inhibition in combination with an ICI (anti-PD1 mAb) diversified the TCR repertoire, upregulated prognostic immune gene markers in the tumor, including markers for recently activated (thus non-exhausted) T cells, and drove infiltration of T cells into syngeneic mouse model tumors. This combination is efficacious across syngeneic models, including different mouse strains and the effects of ERAP1 inhibition on the T cell response correlate with efficacy. Further, ex vivo human T cell co-cultures with cancer cell lines demonstrate that novel and upregulated neoantigens generated by ERAP1 inhibition drive tumor cell killing. In addition, these studies showed enhanced tumor cell killing when an ImmTAC was used in combination with ERAP1 inhibition to enhance presentation of the cancer-specific target peptide. In conclusion, the first-in-class, ERAP1 inhibitor clinical candidate, GRWD5769, drives novel anti-tumor T cell responses through neoantigen creation and circumventing T cell exhaustion. GRWD5769 has demonstrated a good safety profile in GLP toxicology studies and robust proof of mechanism and proof of principle biomarkers have been developed to provide a clear path to establish the activity and efficacy of GRWD5769 in patients in 2023.Citation Format: Andrew Leishman, Wayne Paes, Emma Sparrow, Ana Ribeiro, Michael Cundell, Milos Aleksic, Michael P. Pinggera, Jessica Sette, Kate Anderton, Nicola Ternette, Juliet Morgan, Jason J. Shiers, Martin Quibell, Peter I. Joyce. GRWD5769: A first-in-class inhibitor of ERAP1, generating novel cancer antigens to drive de novo anti-tumor T cell responses [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3467.

15 Jun 2022·Cancer Research

Abstract 2065: A small molecule approach to drive novel neoantigen generation: First-in-class inhibitors of ERAP1 generate novel neoantigens driving anti-tumor effects

Author: Coulson, Richard ; Anderton, Kate ; Shiers, Jason ; Sette, Jessica ; Pinggera, Michael ; Quibell, Martin ; Joyce, Peter Ian ; Paes, Wayne ; Morgan, Juliet ; Ternette, Nicola ; Leishman, Andrew

AbstractImmune checkpoint inhibition (ICI) therapy has changed the cancer treatment paradigm; however, most patients respond poorly to ICI alone. In order to be effective, ICI requires neoantigen expression to drive anti-tumor T cell responses and numerous clinical studies have shown that high neoantigen load and tumor mutation burden correlate with improved patient response. Given the central importance of neoantigens in ICI response there is an urgent need for therapies that generate new neoantigens to drive novel anti-tumour cytotoxic T cell responses thereby increasing the number of patients achieving durable benefit. Grey Wolf are developing inhibitors of endoplasmic reticulum aminopeptidases (ERAP1 and ERAP2) to generate novel neoantigens. ERAP enzymes are members of the antigen presentation pathway, trimming a subset of peptides (15-20%) prior to their loading onto MHC Class I. Strikingly, reduced tumoral expression of ERAP1 in cancer correlates with a 50% increase in overall survival. Independent groups have also shown that ablation of ERAP1 generates neoantigens, causing tumor growth inhibition in various syngeneic models in combination with ICI. Grey Wolf have generated and profiled highly potent and selective ERAP1 inhibitors, leading to the nomination of the first-in-class ERAP1 inhibitor development candidate, GRWD5769. Extensive analysis of the immunopeptidomes of diverse cancer cell lines robustly show that ERAP1 inhibition consistently generates novel neoantigens in vitro and in vivo. Analysis of syngeneic tumor models treated with an orally administered ERAP1 inhibitor in combination with anti-PD-1 show that neoantigen generation produces a differentiated T cell response, including: 1) diversification of the tumoral T cell repertoire; 2) increased infiltration of T cells into tumors; and 3) synergistic upregulation of translationally relevant immune gene markers shown to correlate with response to anti-PD-1 in patients. In addition, elevations in immune mediated effects caused by ERAP1 inhibition in combination with anti-PD-1 correlate with tumor growth inhibition in mouse syngeneic studies. Importantly, ERAP1 inhibitors are well tolerated in mouse, rat, and non-human primates, which aligns with the observations that increases in T cell effects are tumor specific and not observed in peripheral tissue. Our investigation of the effects of ERAP1 inhibitors in mouse tumor models and ex vivo primary human T cell co-cultures have provided proof of mechanism and proof of principle biomarkers that will be used to explore the effects of GRWD5769 during Phase 1 clinical development in the second half of 2022.Citation Format: Andrew Leishman, Wayne Paes, Richard Coulson, Michael Pinggera, Jessica Sette, Kate Anderton, Nicola Ternette, Juliet Morgan, Jason Shiers, Martin Quibell, Peter Ian Joyce. A small molecule approach to drive novel neoantigen generation: First-in-class inhibitors of ERAP1 generate novel neoantigens driving anti-tumor effects [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2065.

01 Jul 2021·Cancer Research

Abstract 1715: First in class inhibitors of ERAP1 have the potential to be a transformative immunotherapy in oncology

Author: Poynton, Fergus ; Leonard, Henry ; Clark, Kristopher ; Quibell, Martin ; Reeves, Emma ; Shiers, Jason ; James, Edd ; Joyce, Peter Ian ; de Almeida, Camila ; Lori, Elisa ; Tong, Carmen ; Leishman, Andrew ; Ternette, Nicola

AbstractClinical data demonstrates increased antigen presentation diversity is an important factor in determining response rates to checkpoint inhibitors. In addition to tumor mutational burden, increased HLA heterozygosity and HLA evolutionary diversity are non-overlapping factors which further diversify the immunopeptidome and improve clinical response to checkpoint therapies. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an enzyme that trims peptides loaded into classical and nonclassical MHC Class I molecules. Human genome-wide association studies have identified single nucleotide polymorphisms within ERAP1 that are associated with immune-related diseases, such as ankylosing spondylitis, providing human genetic validation for ERAP1's role in human disease and antigen presentation. Further, ablation of mouse ERAAP modifies the immunopeptidome, resulting in improved immunogenicity, generation of CD8+ T cell responses and tumor growth inhibition.Grey Wolf Therapeutics have developed highly potent and selective ERAP1 inhibitors. These inhibitors demonstrate significant modulation of the cancer-related antigen repertoire across diverse ERAP1 and HLA genotypes and cancer-type backgrounds, both in vitro and in vivo. These changes in the antigen repertoire drive changes in T cell activation and response, leading to increased T cell infiltration into CT26 syngeneic tumors and T cell receptor (TCR) diversification when combined with anti-PD-1. We have identified immune related markers that are modulated following ERAP1 inhibition in syngeneic tumor models which have the potential to be used as biomarkers. Importantly, ERAP1 inhibitor induced immunopeptidome and T cell changes lead to significant tumor growth inhibition in syngeneic mouse models when combined with anti-PD-1. In parallel, we have demonstrated the ability of ERAP1 inhibitor induced novel cancer associated antigens to stimulate human CD8+ T cell responses. Extensive assessment of the potential of ERAP1 inhibitors to enhance tumor immune responses in combination with additional therapies (e.g. chemotherapy and radiotherapy), across different tumor microenvironments, is ongoing. These data provide the foundation from which we plan to explore the potential of our first-in-class ERAP1 inhibitor development candidate in the clinic.Citation Format: Andrew Leishman, Fergus Poynton, Nicola Ternette, Elisa Lori, Camila de Almeida, Henry Leonard, Emma Reeves, Edd James, Kristopher Clark, Carmen Tong, Jason Shiers, Martin Quibell, Peter Ian Joyce. First in class inhibitors of ERAP1 have the potential to be a transformative immunotherapy in oncology [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1715.

News (Medical) associated with Grey Wolf Therapeutics Ltd.

09 Jul 2024

·www.biospace.com

Pathios Therapeutics Appoints Paul G. Higham as Chief Executive Officer

Founding CEO, Stuart Hughes, Ph.D., to Transition to Chief Scientific Officer and Focus Efforts on Advancing Company's First-of-its-Kind GPR65 Inhibition Approach to Immuno-Oncology Company Continues Active Investor Engagement Following First Close of $25M Series B Financing in Q2 2024; On Target to Enter Clinic by End of Year OXFORD, England, July 9, 2024 /PRNewswire/ -- Pathios Therapeutics Limited ("Pathios"), a biotech company focused on the development of first-in-class therapies for cancer, today announced the appointment of experienced biotechnology industry executive, Paul G. Higham, as Chief Executive Officer (CEO). He brings over 20 years of C-level executive biotechnology company experience to Pathios, as the company prepares to enter clinical development with its first-in-class GPR65 antagonist. In conjunction with Mr. Higham's appointment, Pathios' founding CEO, Stuart Hughes, Ph.D., will transition to the role of Chief Scientific Officer (CSO), where he will continue to focus his efforts and deep scientific expertise on the company's first-of-its-kind GPR65 inhibition approach to cancer immunotherapy. This will include playing a key role on the team advancing PTT-4256, the company's lead internally discovered, oral, highly potent, and selective small molecule inhibitor of GPR65, into human clinical trials in advanced solid cancers by the end of 2024. "Following several years of excellent leadership under Stuart, Pathios is preparing to take a critical step forward and enter the clinic with its lead immuno-oncology program. As we transition from a company with preclinical assets to a full-fledged clinical-stage biotech, we will benefit greatly from Paul's deep operational and strategic expertise. We are thrilled to welcome Paul to the Pathios team and look forward to the successes he will drive, including ongoing fundraising efforts focused on completing our Series B round," said Tom McCarthy Ph.D., co-founder and Executive Chair of Pathios. "Importantly, Stuart will now be able to focus the full force of his scientific acumen on helping shepherd the company's unique therapeutic approach through development to unlock significant value for patients and shareholders alike." Paul most recently served as chief executive officer of Valo Therapeutics, an immuno-oncology company developing tumour antigen-coated oncolytic viruses. In this role, he led the company from pre-clinical stage into clinical development. Prior to his tenure with Valo Therapeutics, Paul held the position of CEO at two other immuno-oncology focused companies, Glycotope, and Immatics Biotechnologies. Earlier in his career, he built a strong foundation of strategic and operational expertise in roles that included commercial development at Ark Therapeutics Group, where he established the company's adenovirus gene-based medicine production facilities in Finland, Vice President, commercial development at GSK, and General Manager of Bayer Pharmaceuticals for Sweden and Denmark. "With an exciting first-in-class therapeutic candidate poised for advancement into first-in-human clinical studies and support from a top-tier investor syndicate of Bristol Myers Squibb, Canaan and Brandon Capital, Pathios is exceptionally well positioned for success. I am delighted to have the opportunity to bring my experience and energy to what is already an exceptional leadership team and help advance the exciting GPR65 antagonist approach at Pathios into much-needed additional therapeutic approaches for patients battling cancer," said Mr. Higham. "This is an exciting time for Pathios as we work diligently toward the initiation of clinical trials for PTT-4256. These studies will allow us to begin to test our scientific hypothesis around the therapeutic potential of inhibiting the immunosuppressive activity of GPR65 in patients with cancer, marking a key step forward for the development of this novel approach to immunotherapy," said Dr. Hughes. "I am looking forward to working alongside Paul to advance this science and support him in executing the strategic and operational initiatives that will best position Pathios for long-term success." Pathios is pursuing a novel immuno-oncology approach to the treatment of cancer focused on counteracting the immunosuppressive polarization of immune cells, including tumour associated macrophages (TAMs), that is triggered by an acidic tumour microenvironment (TME). It does so by attacking a ubiquitous cancer immune evasion pathway through the targeting of GPR65, an acid sensing G protein-coupled receptor that has been shown to foster immunosuppressive polarization of immune cells. GPR65 is exclusively expressed on immune cells and is associated with driving the immunosuppressive immune cell phenotype in the TME that prevents immune-mediated killing of cancer cells. Pathios' internal human genetic analysis demonstrates that reductions in GPR65 function are associated with significantly improved survival across a range of solid tumour types, positioning it as a unique immuno-oncology target for therapeutic intervention. Preclinical data for PTT-4256 have demonstrated that the compound possesses excellent drug-like properties and impressive monotherapy anti-tumour activity. In addition to cancer, there are strong genetic associations between GPR65 activity and a variety of other immunologically mediated diseases, offering Pathios the opportunity to expand its research and development into other high-value therapeutic areas with significant unmet need. About Pathios Therapeutics Pathios is a drug discovery and development company focused on translating innovative science into new medicines. Pathios was founded by a team of experienced biotech and pharmaceutical industry professionals, entrepreneurs, and clinicians. The company is focused on developing small molecule inhibitors of the pH-sensing G protein-coupled receptor GPR65 to counteract the GPR65 mediated immunosuppressive polarization of immune cells, including tumour associated macrophages, that is triggered by an acidic tumour microenvironment present in most cancers. To date, Pathios has raised a total of US$58M including support from the leading venture capital firms, Canaan and Brandon Capital, as well as a strategic investment from Bristol Myers Squibb. Pathios is headquartered at the Innovation Centre on Milton Park, a key science precinct south of Oxford, UK, where together with Grey Wolf Therapeutics and ThirtyFiveBio it is part of the unique M:M Bio drug discovery and development ecosystem. For more information, please visit . Contacts: Pathios Therapeutics Tom McCarthy, Executive Chair +44 1235 644 960 info@pathios.com Paul Higham, CEO +44 1235 644 960 info@pathios.com Vida Strategic Partners (on behalf of Pathios Therapeutics) Tim Brons +1 646 319 8981 tbrons@vidasp.com

Executive ChangeImmunotherapy

03 Jun 2024

·www.prnewswire.com

Grey Wolf Therapeutics Presents First Clinical Data for GRWD5769, a First-in-Class ERAP1 Inhibitor, at the 2024 American Society for Clinical Oncology (ASCO) Annual Meeting

Preliminary data from ongoing Phase 1/2 trial show dose dependent target engagement and provide clinical proof-of-mechanism for GRWD5769, demonstrating ability to modulate the human immunopeptidome with therapeutic intent for first time Company's lead immuno-oncology candidate shown to be well tolerated with predictable pharmacokinetics following oral administration OXFORD, England, June 3, 2024 /PRNewswire/ -- Grey Wolf Therapeutics, a clinical-stage biotechnology company leveraging first-of-its-kind antigen modulation therapies to address the source of immune dysfunction in oncology and autoimmunity, today announced that initial data from the company's ongoing adaptive Phase 1/2 clinical trial of GRWD5769, an investigational first-in-class ERAP1 inhibitor, were reported in a poster presentation at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. The presented data consisted of preliminary findings from the initial repeat dosing monotherapy module of the study and demonstrated well-tolerated dose dependent target engagement following administration of escalating oral doses of GRWD5769. Importantly, the observed modulation of the human immunopeptidome with GRWD5769 provides clinical proof-of-mechanism for the novel immuno-oncology candidate and its foundational antigen modulation technology. "We are highly encouraged by the initial data from our ongoing study, highlighted by the achievement of success in the first known attempt to modulate the immunopeptidome for specific therapeutic purposes. These clear signs of target engagement provide compelling support for our antigen modulation strategy in immuno-oncology, which is designed to allow T cells to recognize new targets on tumour cells and drive de novo anti-tumour responses," said Tom Lillie, M.D., Ph.D., chief medical officer of Grey Wolf Therapeutics. "The presented data demonstrate a promising tolerability profile for GRWD5759 across all four dose levels administered to date, along with achievement of stable disease for a number of patients, some of whom have remained on treatment for nearly a year. These findings strongly support our recent initiation of combination dosing with GRWD5769 and cemiplimab, and our plans for further expansion cohorts in the near future." Grey Wolf has developed and is advancing a unique immuno-oncology therapeutic strategy utilizing a proprietary antigen modulation strategy to reveal novel and potent cancer antigens on the surface of tumour cells. This is achieved through oral delivery of a targeted inhibitor of the endoplasmic reticulum aminopeptidases (ERAP1 or ERAP2), key proteins in the antigen presentation pathway. The targeted inhibition of ERAP is designed to elicit a de novo T cell response against tumours and to avoid T-cell exhaustion, thereby overcoming two key resistance mechanisms to current immuno-oncology therapy. The company is evaluating this novel immuno-oncology approach through the EMITT-1 (ERAP Mediated Immunopeptide Targeting Trial – 1) Phase 1/2 clinical trial. The modular multi-part, multi-arm open-label study is designed to evaluate the safety, tolerability, preliminary efficacy and pharmacokinetics of GRWD5769 alone and in combination with Regeneron's PD-1 inhibitor Libtayo® (cemiplimab) in patients with a range of solid tumour types. Key takeaways from the EMITT-1 trial presented at ASCO include: GRWD5769 was well tolerated, with predictable pharmacokinetics following repeat oral administration in all dose cohorts (up to 200 mg BID). Dose-dependent target engagement as evidenced by modulation of the immunopeptidome. Clinical proof-of-mechanism, confirming the expected mechanistic effects of ERAP1 inhibition and consistent with those seen in preclinical models. Initial, early efficacy assessments demonstrating stable disease achieved by a number of patients, some of whom have remained on treatment for nearly a year. The dose escalation portion of the trial continues as the company seeks to identify the recommended Phase 2 dose for GRWD5769. The company has also recently initiated dosing in the study's first cohort combining GRWD5769 with immune checkpoint inhibition. Grey Wolf recently reported that it is expanding the scope of the study, allowing for the enrolment of patients with additional tumour types. Further information about the EMITT-1 Phase 1/2 clinical trial can be found by searching trial registration number ACTRN12623000108617 on the Australian New Zealand Clinical Trial Registry (). About Grey Wolf Therapeutics Grey Wolf Therapeutics is a clinical-stage, UK- and Australian-based drug discovery and development biotechnology company spearheading a new therapeutic approach based on a first-of-its-kind antigen modulation platform. The company's innovative technology is centered on inhibiting the endoplasmic reticulum aminopeptidases (ERAP1 or ERAP2), which play a key role in the antigen presentation pathway, allowing therapeutic approaches to address the source of immune dysfunction in oncology and autoimmunity. The company's lead clinical development candidate, GRWD5769, is a potent and selective oral ERAP1 inhibitor that has shown the potential to elicit a powerful and differentiated immune response against tumours. A second ERAP1 inhibitor, GRWD0715, is advancing through preclinical development as a potential treatment for autoimmune disease. The company is also leveraging its leadership in neoantigen creation with an ERAP2 drug discovery program and by therapeutically targeting novel ERAP1 inhibitor generated cancer antigens with MHC Class I directed therapies, such as soluble T cell receptor (TCR) and TCR mimic bispecifics. For more information, please visit: Contacts: Grey Wolf Therapeutics Peter Joyce Chief Executive Officer +44 (0) 01235 644 970 [email protected] Vida Strategic Partners (on behalf of Grey Wolf Therapeutics) Tim Brons (Media) 415-675-7402 [email protected] SOURCE Grey Wolf Therapeutics

ImmunotherapyASCO

29 May 2024

·www.prnewswire.com

Grey Wolf Therapeutics to Present First Clinical Data for GRWD5769, a First-in-Class ERAP1 Inhibitor, at the 2024 American Society for Clinical Oncology (ASCO) Annual Meeting

Interim Results from Ongoing Phase 1/2 Clinical Trial of Lead Immuno-Oncology Candidate to be Reported in Poster Presentation OXFORD, UK, May 29, 2024 /PRNewswire/ -- Grey Wolf Therapeutics, a clinical-stage biotechnology company leveraging first-of-its-kind antigen modulation therapies to address the source of immune dysfunction in oncology and autoimmunity, today announced that the first clinical data for the company's lead immuno-oncology candidate, GRWD5769, will be presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting. The presented findings will consist of initial data from the company's ongoing Phase 1/2 clinical trial of the first-in-class ERAP1 inhibitor in a range of solid tumour types. The 2024 ASCO Annual Meeting is being held May 31 – June 4, 2024, in Chicago, IL. Details of the company's presentation at the 2024 ASCO Annual Meeting are as follows: Abstract Number: 2589 Title: EMITT-1: Proof-of-mechanism immunopeptidome (ImPD) effects at target PK exposure, in a Phase 1 study of GRWD5769 (a first-in-class inhibitor of Endoplasmic Reticulum Aminopeptidase 1 [ERAP1]) in patients with solid malignancies Presenting Author: Thomas Lillie, M.D., Ph.D., Chief Medical Officer of Grey Wolf Therapeutics Poster Session: Development Therapeutics - Immunotherapy Date/Time: Saturday, June 1, 2024, 9:00 a.m. Central Time Location: Poster Hall – Hall A Grey Wolf has developed and is advancing a unique immune-oncology therapeutic strategy utilizing a proprietary antigen modulation strategy to reveal novel and potent cancer antigens on the surface of tumour cells. This is achieved through oral delivery of a targeted inhibitor of the endoplasmic reticulum aminopeptidases (ERAP1 or ERAP2), key proteins in the antigen presentation pathway. The targeted inhibition of ERAP is designed to elicit a de novo T cell response against tumours and to avoid T-cell exhaustion, thereby overcoming two key resistance mechanisms to current immuno-oncology therapy. The company is conducting an ongoing adaptive Phase 1/2 clinical trial of GRWD5769, which is evaluating the safety, tolerability, and efficacy of GRWD5769, including a planned combination with the PD-1 inhibitor Libtayo® (cemiplimab), in a range of solid tumour types. The company recently reported that it is expanding the scope of the Phase 1/2 trial, allowing for the enrolment of patients with additional tumour types. Additionally, the company has also recently initiated dosing in the study's first combination treatment cohort. About Grey Wolf Therapeutics Grey Wolf Therapeutics is a clinical-stage, UK- and Australian-based drug discovery and development biotechnology company spearheading a new therapeutic approach based on a first-of-its-kind antigen modulation platform. The company's innovative technology is centered on inhibiting the endoplasmic reticulum aminopeptidases (ERAP1 or ERAP2), which play a key role in the antigen presentation pathway, allowing therapeutic approaches to address the source of immune dysfunction in oncology and autoimmunity. The company's lead clinical development candidate, GRWD5769, is a potent and selective oral ERAP1 inhibitor that has shown the potential to elicit a powerful and differentiated immune response against tumours. A second ERAP1 inhibitor, GRWD0715, is advancing through preclinical development as a potential treatment for autoimmune disease. The company is also leveraging its leadership in neoantigen creation with an ERAP2 drug discovery program and by therapeutically targeting novel ERAP1 inhibitor generated cancer antigens with MHC Class I directed therapies, such as soluble T cell receptor (TCR) and TCR mimic bispecifics. For more information, please visit: Contacts: Grey Wolf Therapeutics Peter Joyce Chief Executive Officer +44 (0) 01235 644 970 [email protected] Vida Strategic Partners (on behalf of Grey Wolf Therapeutics) Tim Brons (Media) 415-675-7402 [email protected] SOURCE Grey Wolf Therapeutics

ImmunotherapyASCOPhase 1

100 Deals associated with Grey Wolf Therapeutics Ltd.

100 Translational Medicine associated with Grey Wolf Therapeutics Ltd.

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 28 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

Preclinical

Phase 2 Clinical

Current Projects

Drug(Targets)	Indications	Global Highest Phase

GRWD-5769 ( ERAP1 )	Solid tumor More	Phase 2 Clinical
GRWD-0715 ( ERAP1 )	Autoimmune Diseases More	Preclinical
ERAP2 (Grey Wolf Therapeutics) ( ERAP2 )	Neoplasms More	Preclinical
MHCI directed therapies(Grey Wolf Therapeutics)	Neoplasms More	Discovery

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Grey Wolf Therapeutics Ltd.

Overview

Tags

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 28 Nov 2024

Current Projects

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing