Surgical and Anesthesiological-resuscitation Aspects of Therapeutic Tactics for Thrombotic and Hemorrhagic Complications in Patients With the New Coronavirus Infection COVID-19

The nature of the planned study:
The topic is of an applied nature and is aimed at improving the results of comprehensive treatment of patients with COVID-19, the course of whose disease was complicated by thrombotic or hemorrhagic catastrophes.
It is planned to analyze the results of treatment of this category of patients based on the work of several centers that provided surgical care to patients with COVID-19 during the pandemic (8 cities).
As a result of the analysis, it is planned to develop algorithms for the prevention and treatment of thrombotic and hemorrhagic complications in patients with COVID-19.
The proposed study will be multicenter, cohort, retrospective.
The purpose of the study:
Improvement of treatment results in COVID-19 patients with thrombotic or hemorrhagic complications
Scientific novelty:
For the first time, as a result of a multicenter study, it is expected to identify the most effective approach to the treatment and prevention of thrombotic and hemorrhagic complications in patients with COVID-19.
For the first time, it is planned to develop and put into practice algorithms for the application of the most effective methods of treatment and prevention of thrombohemorrhagic complications of COVID-19.

Start Date12 Jan 2024

Sponsor / Collaborator

Volgograd State Medical University

NCT04244435

/ Unknown statusEarly Phase 1IIT

Consequences of Using Thoracic Epidural Analgesia for Coronary Artery Bypass Grafting

Investigators plan to study the effect of thoracic epidural analgesia on postoperative parameters (complication rate, duration of hospitalization, mortality, etc.) of coronary artery bypass grafting.

Start Date01 Feb 2020

Sponsor / Collaborator

Volgograd State Medical University

NCT04023565

/ Unknown statusPhase 4IIT

Open-Label Non-Comparative Study of the Effects of a Combination Antihypertensive Treatment With Moxonidine + Perindopril in Hypertensive Patients With Metabolic Syndrome

The aim of study is to assess the angioprotective effects of antihypertensive combination therapy with perindopril 10 mg and moxonidine 0.4-0.6 mg in patients with arterial hypertension, metabolic syndrome, and obesity, who had Pulse Wave Velocity (PWV) > 10 m/s on the previously administered two-component combination antihypertensive therapy.
Open-label non-comparative prospective study for 24 week for each patient.

Start Date11 Mar 2019

Sponsor / Collaborator

Volgograd State Medical University

100 Clinical Results associated with Volgograd State Medical University

0 Patents (Medical) associated with Volgograd State Medical University

438

Literatures (Medical) associated with Volgograd State Medical University

11 Apr 2025·Current Alzheimer Research

Influence of Inflammation, Gut Microbiota, and Stress on Cognition and Oral Health Therapies

Article

Author: Liye, An ; Loktionova, Marina ; Zhang, Xinliang ; Glazachev, Oleg ; Saichao, Zhou ; Gavrikov, Leonid K.

Background:Prolonged or repeated psychological stress triggers dental and orthodontic diseases via inflammatory pathways and oxidative stress. This review aims to elucidate the role of inflammation, gut microbiota, stress, and cognition, exploring their impact on the development of therapeutics to enhance oral health.Objective:The primary aim pertinent to this systematic review is to elucidate the significant implications of cognition and stress in dental and orthodontic health. Specifically, the review aims to (1) investigate the association between emotional stress and the incidence or progression of periodontal disease; (2) explore the impact of physiological and emotional stress on cellular and molecular inflammatory responses in orthodontics; (3) examine the influence of gut-mediated psychophysiological factors on emotional changes in mental health and cognition with a focus on periodontics and orthodontics; and (4) investigate the potential of gut microbiota alterations to influence oral and cognitive/mental health, including the impact of probiotic supplementation and dietary interventions.Methods:A systematic review was conducted without comprehensive meta-analysis, focusing on literature from 1960 to 2024. Databases searched included PubMed, Embase, ReleMed, National Library of Medicine (NLM), Scopus, and Google Scholar. Keywords used were “cognition,” “emotional stress,” “gut microbiota,” “orthodontics,” “prosthetics,” “pathophysiology,” and “mental health.” Studies were selected based on relevance, publication date, access to full texts, and adherence to PRISMA guidelines. The review integrated findings on the impact of emotional stress on periodontal disease and orthodontic health through pathophysiological implications.Results:Age-related neurodegeneration causes Alzheimer’s disease and severe dementia that subsequently promotes poor oral health. The review identified a complex interplay between emotional stress and periodontal disease. While a direct association remains to be conclusively proven, several studies highlight the influence of stress on the severity and incidence of periodontal disease through inflammatory and immunological pathways. Stress manifests in various ways, such as increased masticatory muscle tone, changes in eating behavior, and the initiation of bruxism, all of which can affect dental health. Physiological stress induces an inflammatory response to orthodontic tooth movement, impacting orthodontic treatment outcomes. Furthermore, the review elucidates the role of gut-mediated psychophysiological factors in emotional changes, influencing periodontal and orthodontic health. Emerging evidence suggests that gut microbiota alterations can significantly impact oral and cognitive health through systemic inflammation and neuroimmune mechanisms.Conclusion:This review highlights the significant impact of physiological and emotional stress on periodontal and orthodontic health. Detailed exploration of cellular and molecular inflammatory responses provides insights into the pathophysiology of orthodontic diseases and their impact on oral health. Gut-brain-oral axis has significance in oral health, exploring how alterations in gut microbiota influence oral and cognitive health. It is essential to investigate the impact of probiotic supplementation and dietary modifications on gut microbiota composition, systemic inflammation, and their influence on both cognitive and oral health. Clinical trials assessing the effectiveness of anti-inflammatory treatments in reducing periodontal disease and cognitive decline could offer valuable insights. Integrating advanced microbiome analysis techniques and neuroimaging can help clarify the mechanisms linking gut health, systemic inflammation, and cognitive function. Exploring specific gut microbiota strains that regulate systemic inflammation and cognitive function may lead to targeted probiotic therapies, potentially alleviating neuroinflammation and enhancing cognitive performance. Additionally, understanding the role of oral probiotics in periodontal health and their effects on gut microbiota and systemic inflammation could contribute to the development of innovative treatment approaches. This knowledge can aid molecular biologists, dentists, and researchers in managing oral and gut health more effectively.

09 Apr 2025·Pirogov Russian Journal of Surgery

Factors of delayed gastric emptying after pancreaticoduodenectomy

Article

Author: Puzikova, A.V. ; Postolov, M.P. ; Linchenko, A.A. ; Suvorov, V.A. ; Lyubimov, M.A. ; Panova, A.V. ; Tolstopyatov, S.E. ; Panin, S.I.

Objective. To study the factors of delayed gastric emptying after pancreaticoduodenectomy using artificial intelligence Material and methods. The study included 142 patients after pancreaticoduodenectomy for malignant pancreaticoduodenal tumors. The probability of delayed gastric emptying was determined using neural network analysis (SPSS Statistics v.26). Quality of the model was assessed considering sensitivity, specificity, diagnostic efficacy and AUROC. Results. Delayed gastric emptying after pancreaticoduodenectomy occurred in 33 (23.2%) patients. In multivariate analysis, delayed gastric emptying was associated with BMI > 30 kg/m2, tumor diameter ≤2 cm and postoperative pancreatitis. Model sensitivity was 93.9%, specificity 97.2%, diagnostic efficacy 96.5%, AUROC 0.924±0.011 (95% CI: 0.834—0.967). Conclusion. Artificial intelligence makes it possible to determine the factors of delayed gastric emptying after pancreaticoduodenectomy.

08 Apr 2025·S.S. Korsakov Journal of Neurology and Psychiatry

The study of the behavioral reactions and duration of ultrasonic vocalization in rats from females stressed during pregnancy

Article

Author: Frolov, E.M. ; Muzyko, E.A. ; Karelina, D.A. ; Frolov, M.Yu. ; Tarasov, A.S. ; Lukina, A.S. ; Perfilova, V.N.

Objective. To study the psycho-emotional state and its relationship to the duration of ultrasonic vocalization in the offspring of rats with physiological and stress-complicated pregnancy. Material and methods. The experiments were performed on the offspring (n=120) of rats with physiological pregnancy and the offspring of animals stressed during the entire gestation period (21—23 days). Study animals were divided into the following groups: 1 — intact — males and females (n=52) born to healthy rats; 2 — stress — males and females (n=68) born to rats that underwent stress during pregnancy. At the age of 17 days, the total vocalization duration (at 50 kHz) was recorded in rats. To assess the psycho-emotional state of the offspring, the open field and elevated plus maze tests were performed at 22 days, marble burying at 35 days, and Porsolt forced swimming test at 47 days. To assess cognitive function in the offspring, short-term working memory was examined in the recognition of a new object test at 35 days and long-term memory in the conditioned passive avoidance reflex test at the age of 47 days. Results. The results of the open field and elevated plus maze tests indicated that the offspring of females stressed during pregnancy showed anxious behavior. In addition, animals from stressed rats exhibited compulsive and depressive behaviors in the marble burying and Porsolt forced swimming tests. The offspring of stressed rats showed impaired reproduction of the memory traces in the conditioned passive avoidance reflex test. Conclusion. In the offspring of females stressed during pregnancy, anxious, compulsive, and depressive behavior is observed, accompanied by an increase in the duration of ultrasonic vocalization at 50 kHz.

100 Deals associated with Volgograd State Medical University

100 Translational Medicine associated with Volgograd State Medical University

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