A prospective study of reRNA™ HPV tumor vaccine alone or in combination with immune checkpoint inhibitors in patients with HPV16/18-positive unresectable recurrent or metastatic solid tumors

Start Date24 May 2023

Sponsor / Collaborator

The First Affiliated Hospital of Nanyang Medical College

ChiCTR2200066118 / RecruitingPhase 1

A Clinical Pharmacology Exploratory Study of RNA tumor vaccine injection alone or combined with PD-1 inhibitors in the treatment of advanced melanoma

Start Date24 Nov 2022

Sponsor / Collaborator

The First Affiliated Hospital of Nanyang Medical College

ChiCTR2200061327 / SuspendedEarly Phase 1

A clinical study of AAV vector expressing human coagulation factor FVIII gene therapy for hemophilia A

Start Date06 Jun 2022

Sponsor / Collaborator

The First Affiliated Hospital of Nanyang Medical College

100 Clinical Results associated with The First Affiliated Hospital of Nanyang Medical College

0 Patents (Medical) associated with The First Affiliated Hospital of Nanyang Medical College

373

Literatures (Medical) associated with The First Affiliated Hospital of Nanyang Medical College

01 Dec 2024·Cellular and Molecular Neurobiology

The Efficacy of Different Material Scaffold-Guided Cell Transplantation in the Treatment of Spinal Cord Injury in Rats: A Systematic Review and Network Meta-analysis

Review

Author: Li, Meihua ; Xie, Zhiping ; Guo, Boyu ; Wang, Zhihua ; Xu, Tianqi ; Li, Jun

AbstractCell transplantation is a promising treatment option for spinal cord injury (SCI). However, there is no consensus on the choice of carrier scaffolds to host the cells. This study aims to evaluate the efficacy of different material scaffold-mediated cell transplantation in treating SCI in rats. According to PRISMA’s principle, Embase, PubMed, Web of Science, and Cochrane databases were searched, and relevant literature was referenced. Only original research on cell transplantation plus natural or synthetic scaffolds in SCI rats was included. Direct and indirect evidence for improving hind limb motor function was pooled through meta-analysis. A subgroup analysis of some factors that may affect the therapeutic effect was conducted to understand the results fully. In total, 25 studies met the inclusion criteria, in which 293 rats received sham surgery, 78 rats received synthetic material scaffolds, and 219 rats received natural materials scaffolds. The network meta-analysis demonstrated that although synthetic scaffolds were slightly inferior to natural scaffolds in terms of restoring motor function in cell transplantation of SCI rats, no statistical differences were observed between the two (MD: −0.35; 95% CI −2.6 to 1.9). Moreover, the subgroup analysis revealed that the type and number of cells may be important factors in therapeutic efficacy (P < 0.01). Natural scaffolds and synthetic scaffolds are equally effective in cell transplantation of SCI rats without significant differences. In the future, the findings need to be validated in multicenter, large-scale, randomized controlled trials in clinical practice.Trial registration: Registration ID CRD42024459674 (PROSPERO).Graphical Abstract

01 Dec 2024·Journal of Trace Elements in Medicine and Biology

The novel prognostic analysis of AML based on ferroptosis and cuproptosis related genes

Article

Author: Kong, Chunfang ; Ding, Weirong ; Cheng, Hongbo ; Li, Anan ; Jin, Chenghao ; Wan, Caishui ; Zhang, Tingting ; Wei, Yujing ; Ke, Bo ; Wu, Mei

BACKGROUNDAcute myeloid leukemia (AML) is a hematological malignancy. The aim of this research was to develop a ferroptosis and cuproptosis related novel prognostic signature associated with AML.METHODSThe ferroptosis and cuproptosis related genes correlated with the prognosis of AML were identified by univariate Cox analysis. The consistent cluster analysis was performed for 150 AML patients in TCGA dataset. The key module genes associated with GSVA score of ferroptosis and cuproptosis were identified by WGCNA. univariate Cox and LASSO regression analysis were adopted to build a ferroptosis and cuproptosis AML prognostic signature. Finally, the expression of five prognostic genes in clinical tissue samples were verified by RT-qPCR.RESULTSA grand total of 27 FCRGs associated with AML prognosis were identified.Then, two AML sub-types with significantly different survival were obtained. We found 3 significantly differential expressed immune cells (naive CD4 cells, regulatory T cells and resting mast cells) between two risk sub-groups. Meanwhile, 'IL6 JAK STAT3 signaling' and 'P53 pathway' were enriched in low-risk group. A ferroptosis and cuproptosis related prognostic signature was build based on 8 prognostic genes. RT-qPCR results indicated that there was no significant difference in the expression of OLFML2A and CD109 between AML and normal samples. However, compared to the control group, LGALS1, SOCS1, and RHOC showed significantly lower expression in the AML group.CONCLUSIONThe prognostic signature comprised of OLFML2A, LGALS1, ABCB11, SOCS1, RHOC, CD109, RD3L and PTPN13 based on ferroptosis and cuproptosis was established, which provided theoretical basis for the research of AML.

01 Dec 2024·Journal of Affective Disorders

The role of physical activity in mitigating stress-induced internet addiction among Chinese college students

Article

Author: Chen, Xiangfan ; Luo, Man ; Duan, Zhizhou

BACKGROUNDThis study addresses the nexus of stress, physical exercise, and internet addiction in college students, aiming to unravel their complex interactions. With prior research hinting at correlations, this study seeks deeper insights into the optimal exercise duration and the mediating role of physical activity in the stress-internet addiction relationship.METHODSWe examined 2892 Chinese college students, assessing psychosocial traits via established scales: the Chinese Internet Addiction Scale (CIAS-R), International Physical Activity Questionnaire (IPAQ), and DASS-21 for stress. We adopted a questionnaire survey method to collect data, and through convenience sampling, participants were selected. Analysis involved Structural Equation Model (SEM) and restricted cubic splines (RCS).RESULTSAmong participants, 22.0 % self-reported internet addiction symptoms. Notably, a non-linear correlation between moderate (MPA) and vigorous physical activity (VPA) and internet addiction was evident (P < 0.001), while light physical activity (LPA) showed no significant association (P = 0.182). MPA initially reduced internet addiction as activity hours increased, but its efficacy lessened after 0.8 h/day. Conversely, VPA's impact fluctuated, declining from 0 to 0.18 h/day, then stabilizing. SEM analysis highlighted VPA and MPA's partial mediation in the stress-internet addiction relationship. Specifically, the path coefficient from stress to MPA was -0.037 (P < 0.05), and the path coefficient from MPA to internet addiction was -0.056 (P < 0.01). Additionally, the path coefficient from stress to VPA was -0.067 (P < 0.001), and the path coefficient from VPA to internet addiction was -0.102 (P < 0.001).CONCLUSIONThis study unveils the intricate interplay between physical activity, stress, and internet addiction among college students. With 22.0 % reporting addiction symptoms, urgent interventions tailored to promoting healthy physical activity levels are imperative to mitigate internet addiction risks.LIMITATIONSThe cross-sectional nature of our design precludes the establishment of causal relationships between psychological stress and internet addiction.

100 Deals associated with The First Affiliated Hospital of Nanyang Medical College

100 Translational Medicine associated with The First Affiliated Hospital of Nanyang Medical College

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