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Nervous System Diseases

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GD2(Disialoganglioside GD2)	1

Author: Kendrick, Tina ; Waak, Michaela ; Long, Debbie ; Hall, Lisa ; Copnell, Beverley ; Harnischfeger, Jane ; Lake, Anna ; Davies, Kylie ; Forrest, Kate ; Erikson, Simon ; Ullman, Amanda ; Woodard, Mark ; Brown, Georgia ; Tume, Lyvonne ; Cooke, Marie ; Mitchell, Marion ; Irwin, Adam ; Charles, Karina ; Dargaville, Peter ; Schults, Jessica ; Ntoumenopoulos, George

01 Jun 2025·Clinical Neurophysiology

Diagnostic utility of threshold tracking TMS paradigms in early amyotrophic lateral sclerosis

Article

Author: Vucic, Steve ; Farrar, Michelle A ; Calma, Aicee Dawn ; van den Bos, Mehdi A J ; Silva, Cláudia Santos ; Yiannikas, Con ; Menon, Parvathi ; Kiernan, Matthew C ; Pavey, Nathan

OBJECTIVEThreshold tracking transcranial magnetic stimulation (TMS) has exhibited utility as a diagnostic technique in Amyotrophic Lateral Sclerosis (ALS). Different threshold tracking paradigms have recently been proposed. The present study assessed the diagnostic utility of serial ascending and parallel threshold tracking TMS in ALS.METHODSThreshold tracking TMS was undertaken on 90 prospectively recruited participants suspected of ALS. Short interval intracortical inhibition (SICI) was recorded with serial ascending and parallel threshold tracking paradigms between Interstimulus Interval (ISI) 1-to-7 ms. The primary outcome measure was differences in diagnostic utility of the paradigms in differentiating ALS from ALS mimicking disorders using receiver operating characteristic (ROC) analysis (DeLong statistical method).RESULTSReduction in SICI reliably differentiated ALS from mimic disorders, irrespective of the threshold tracking paradigm. Comparison of area under the curve (AUC) established a significantly higher value for mean SICI (1-7 ms) with the serial ascending SICI paradigm (0.81, 95 % confidence interval 0.72-0.91) compared to the parallel paradigm (SICI 0.72, 95 % confidence interval 0.61-0.83, p = 0.0065). The better diagnostic utility of serial ascending paradigm was evident for SICI recorded between 1-to-5 ms, and was maintained irrespective of disease onset site, degree of functional impairment, and the degree of lower motor neuron dysfunction. A comparable diagnostic utility across threshold tracking paradigms was evident in ALS participants who presented with a relative paucity of upper motor neuron signs.CONCLUSIONWhile threshold tracking TMS reliably differentiated ALS from mimic disorders, the present study established better diagnostic utility with the serial ascending threshold tracking TMS paradigm.SIGNIFICANCEThe serial ascending threshold tracking TMS should be used in a clinical setting as a diagnostic tool for ALS.

01 Jun 2025·Pediatric Neurology

Postconcussion Clinical Insomnia is Associated With Heightened Symptom Severity and Delayed Recovery in Children and Adolescents

Article

Author: Orr, Rhonda ; Cassimatis, Maree ; Browne, Gary ; Fyffe, Andrew

BACKGROUNDThere is limited evidence on the prevalence and implications of specific types of sleep disturbance in pediatric concussion. This study aimed to (1) identify the prevalence of postconcussion clinical insomnia (PCCI) in children, (2) determine the impact of PCCI on concussion recovery outcomes, and (3) ascertain clinical characteristics associated with PCCI.METHODSA cross-sectional study was conducted in patients (n = 164, aged 9-17 years) presenting to a pediatric tertiary referral concussion clinic from January 2021 to December 2022. PCCI was identified using the Insomnia Severity Index. Characteristics, including symptom severity, cognitive function, sleep hygiene behavior, and exercise tolerance, were compared between patients presenting with and without insomnia postinjury. A subgroup analysis of recovered patients was undertaken to determine the impact of PCCI on concussion recovery duration.RESULTSOver one third of patients (n = 59, 36%) presented with PCCI. Symptom severity was three times greater in patients with PCCI compared with patients without insomnia postconcussion (P < 0.001). Patients with PCCI had inferior cognitive function in verbal memory (P = 0.01) and visual memory (P = 0.02) cognitive test domains and poorer sleep hygiene behavior (P < 0.001). The subgroup analysis of recovered patients (n = 113) revealed that patients with PCCI had a significantly prolonged recovery duration, taking over one month longer to recover compared with patients without insomnia postinjury (mean recovery duration: 89 vs 57 days, P = 0.004).CONCLUSIONSPCCI is an important contributing factor of symptom burden and severity in pediatric concussion.

100 Deals associated with Sydney Childrens Hospitals Network

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Pipeline

Pipeline Snapshot as of 03 Sep 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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