苯环喹溴铵鼻用喷雾剂代谢性相互作用(作用药物:帕罗西汀)试验
[Translation] Metabolic interaction of benzoquinium bromide nasal spray (acting drug: paroxetine) trial
本试验通过比较苯环喹溴铵单独用药及与帕罗西汀合并用药条件下苯环喹溴铵的主要药动学参数及药动学特征的变化情况,评价代谢酶CYP2D6的抑制剂与苯环喹溴铵鼻用喷雾剂合并给药后,是否会发生对苯环喹溴铵鼻用喷雾剂的代谢性药物相互作用。
[Translation] In this study, by comparing the changes of the main pharmacokinetic parameters and pharmacokinetic characteristics of fencycloquinium bromide under the conditions of phencycloquinium bromide alone and in combination with paroxetine, we evaluated the inhibitor of metabolic enzyme CYP2D6 and fencycloquine. Are there any metabolic drug interactions with benzoquinium bromide nasal spray following co-administration of bromide nasal spray.
苯环喹溴铵鼻用喷雾剂180 μg剂量组的单次和多次给药人体药代动力学试验
[Translation] Single- and multiple-dose human pharmacokinetics of benzoquinium bromide nasal spray 180 μg
对健康受试者进行苯环喹溴铵鼻用喷雾剂180 μg剂量的单次和多次给药人体药代动力学试验,观察健康受试者单次和多次给药后苯环喹溴铵的经时血药浓度,计算主要药代动力学参数,为申报生产和后续临床试验提供参考。
[Translation] A single and multiple administration human pharmacokinetic test of benzoquine bromide nasal spray of 180 μg was performed on healthy subjects, and the healthy subjects were observed after single and multiple administration of benzoquine bromide The time-dependent plasma concentration of ammonium is used to calculate the main pharmacokinetic parameters to provide a reference for the declaration of production and subsequent clinical trials.
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