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Last update 07 Mar 2025
LifeCell International Pvt Ltd.
Last update 07 Mar 2025
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CTRI/2021/10/037427
A Phase 3, Open label, multicenter, triple arm, Randomized clinical trial to determine the efficacy of Dehydrated human amnion chorion membrane allograft (AmchoPlast) and Dehydrated human amnion chorion membrane allograft - Polyhexamethylene Biguanide (AmchoPlast PHMB) with Standard Care alone in treatment of acute wounds.
CTRI/2021/09/036645
Evaluation of Safety and Efficacy of Human UmbilicalCord Derived Mesenchymal Stem Cells (MSCs) inPatients with Moderate to Severe SARS-CoV-2 Infection(SpO2 �94% and Respiratory Rate �24 per minute): AnAdaptive, Seamless Phase-1/Phase-2, Prospective,Open-labelled, Multi-center Study
100 Clinical Results associated with LifeCell International Pvt Ltd.
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04 Oct 2024Cureus Journal of Medical Science
Thanatophoric Dysplasia With Concurrent Hydroureteronephrosis: A Rare Case Report From Rural Southern India
Article
Author: V, Pratheep ; V, Soundharya ; Gambhir, Prakash
Thanatophoric dysplasia (TD) is a severe and typically fatal skeletal disorder caused by mutations in the FGFR3 gene, often leading to perinatal death. It is characterized by extreme short-limb dwarfism and, occasionally, associated anomalies such as hydronephrosis. Prenatal diagnosis, usually made in the third trimester through ultrasound and genetic testing, is crucial for guiding management decisions. Here, we report a case of TD with hydronephrosis diagnosed at 24 weeks of gestation in a 24-year-old primigravida from rural southern India. Ultrasound findings included significantly short and curved long bones, leading to the termination of the pregnancy. A post-termination examination confirmed the presence of dysplastic bones, a large head, and hydronephrosis, with histopathological analysis revealing obstructive uropathy. This case underscores the rarity of TD with hydronephrosis and highlights the importance of early and accurate prenatal diagnosis through ultrasound and molecular testing. Despite the challenges in diagnosing TD, especially when additional anomalies are present, early detection in the second trimester can play a crucial role in guiding genetic counseling and management decisions.
01 Sep 2023Virusdisease
Genotypic characterization of HPV serotypes in cervical samples from Indian women: a multi centric study
Article
Author: V, HariBalaji ; Sarvesan, Ganesh Kumar ; Parthasarathy, Krupakar ; Padhiar, Chirayu
Human papilloma virus (HPV infection) plays a important role in causing cervical cancer. Out of 184 different HPV genotypes, 40 diverse types only can cause anogenital infection. HPV present in >99% of cervical cancers with high risk types (16, 18) associated with cancer and Low risk types (6, 11) are associated with genital warts. Aim of the study is to determine the epidemiology of HPV infection in Indian women's population. Three hundred and thirty four liquid based cytology (LBC) samples were collected across India from the different age groups of Indian women. Pap smear, PCR and gene sequencing tests were performed for the collected LBC samples. Low risk serotype 6 (16.7%) were detected compared to other high risk serotypes. Majority of positive cases were observed in the age group between 19 and 39 groups. Northern part of India contributes high (7.1%) in HPV infection compared to other regions of India. Reports from these studies covered few regions of India showing a wide range in the prevalence of HPV infection and serotype distribution due to diversified socio economic and geo climatic conditions. This study aims to identify the epidemiology of HPV in the Indian population and concludes that early and periodic screening of women for HPV can avoid the risk of cervical cancer at the early stage of infection.
01 Aug 2023INDIAN PEDIATRICS
SCN1A Gene Mutations in Indian Children With Epilepsy: Single Center Experience
Article
Author: Maruthi, Goske ; Soundraoandiyan, Jagatheesh ; Dhayalan, Pavithra ; Kumaran, Priyanka ; Gambhir, Prakash
OBJECTIVE:
To study prevalence of SCN1A gene mutations in complex seizure disorders.
METHODS:
Retrospective laboratory based study on samples sent for molecular diagnosis in complex seizure disorders. Exome sequencing was performed. Phenotype- genotype correlation was done for patients showing variants in SCN1A gene.
RESULTS:
364 samples were evaluated; of which, 54% were of children below 5 years of age. SCN1A mutations were seen in 50 samples of patients with complex seizure disorders; 44 variants were identified. Types of seizure disorders commonly associated were Dravet syndrome and genetic epilepsy with febrile seizures.
CONCLUSIONS:
SCN1A mutations are common in complex seizure disorders, especially Dravet syndrome. Early identification of SCN1A gene in etiology is important for selection of correct antiepileptic and counselling.
100 Deals associated with LifeCell International Pvt Ltd.
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100 Translational Medicine associated with LifeCell International Pvt Ltd.
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