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AbstractCancers of the gastrointestinal (GI) tract, including colorectal, pancreatic, and hepatocellular carcinomas, represent a significant global health burden due to their high incidence and mortality rates. Doublecortin‐like kinase 1 (DCLK1), initially identified for its role in neurogenesis, has emerged as a crucial player in GI cancer progression. This review comprehensively examines the multifaceted roles of DCLK1 in GI cancers, focusing on its structural isoforms, functions in normal and inflammatory states, and contributions to cancer progression and metastasis. DCLK1 is overexpressed in various GI cancers and is associated with poor prognosis, enhanced tumorigenic potential, and increased metastatic capacity. The review discusses the molecular mechanisms through which DCLK1 influences cancer stem cell maintenance, epithelial‐mesenchymal transition (EMT), and cell survival pathways, as well as its interactions with key signaling pathways such as Notch, WNT/β‐catenin, and NF‐κB. The potential of DCLK1 as a therapeutic target is also explored, highlighting preclinical and early clinical efforts to inhibit its function using small molecule inhibitors or monoclonal antibodies. Despite significant advancements, further research is needed to fully elucidate DCLK1's role in GI cancers and to develop effective therapeutic strategies targeting this protein.

01 Jan 2025·Clinical Case Reports

Iatrogenic Botulism After Cosmetic Use of Botulinum Toxin‐A: A Case Series

Article

Author: Mostafazadeh, Babak ; Asadi, Mohammad ; Shadnia, Shahin ; Evini, Peyman Erfan Talab ; Zandieh, Faraz ; Rahimi, Mitra

ABSTRACTBotulism symptoms after cosmetic botulinum toxin‐A (BTX‐A) injections happen very rarely, and it needs careful attention since it can be life‐threatening. Hence, it is advised to meticulously check the technique, dose, and authenticity of the BTX‐A before injections to reduce the adverse effects.

01 Jul 2023·Clinical Case Reports

A rare case report of lead encephalopathy due to high blood lead level

Author: Shadnia, Shahin ; Mostafazadeh, Babak ; Roshanzamiri, Soheil ; Evini, Peyman Erfantalab ; Rahimi, Mitra ; Masbough, Farnoosh

AbstractHere we report a case of lead poisoning having a serum lead level of 412 mcg dL−1 who presented with decreasing level of consciousness and recurrent seizures. He responded well to treatment with chelation therapy.

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