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MechanismD1 receptor antagonists |
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Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc.US |
First Approval Date19 Nov 1946 |
马来酸甲麦角新碱片在健康人体内采用随机、开放、单中心药代动力学研究
[Translation] A randomized, open-label, single-center pharmacokinetic study of methylergonovine maleate tablets in healthy volunteers
通过马来酸甲麦角新碱片单次给药、食物影响、多次给药的药代动力学研究,测定血浆中甲麦角新碱浓度,评价药物在健康人体内吸收、分布和消除特点,及是否存在蓄积现象,为制定合理的临床给药方案提供依据,并初步评价马来酸甲麦角新碱片在女性健康受试者中的安全性。
[Translation] Through the pharmacokinetic study of single administration, food effect, and multiple administration of methylergonovine maleate tablets, the concentration of methylergonovine in plasma was determined, the absorption, distribution, and elimination characteristics of the drug in healthy humans were evaluated, and whether there was accumulation, to provide a basis for formulating a reasonable clinical dosing regimen, and to preliminarily evaluate the safety of methylergonovine maleate tablets in healthy female subjects.
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