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Endocrinology and Metabolic Disease

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Small molecule drug

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Disease Domain	Count

Endocrinology and Metabolic Disease	1

Top 5 Drug Type	Count

Small molecule drug	2

Top 5 Target	Count

CB1R(Cannabinoid CB1 receptor)	2

A review.Beta titanium alloys were recognized as a distinct materials class in the 1950s, and following the introduction of Ti-13V-11Cr-3Al in the early 1960s, intensive research occurred for decades thereafter.By the 1980s, dozens of compositions had been explored and sufficient work had been accomplished to warrant the first major conference in 1983.Metallurgists of the time recognized beta alloys as highly versatile and capable of remarkable property development at much lower component weights than steels, coupled with excellent corrosion resistance.Although alloys such as Ti-15V-3Al-3Sn-3Cr, Ti-10V-2Fe-3Al and Ti-3Al-8V-6Cr-4Mo-4Zr (Beta C) were commercialized into well-known airframe systems by the 1980s, Ti-13V-11Cr-3Al was largely discarded following extensive employment on the SR-71 Blackbird.The 1990s saw the implementation of specialty beta alloys such as Beta 21S and Alloy C, in large part for their chem. and oxidation resistance.It was also predicted that by the 1990s, cost would be the major limitation on expansion into new applications.This turned out to be true and is part of the reason for some stagnation in commercialization of new such compositions over the past two decades, despite a good understanding of the relationships among chem., processing, and performance and some very attractive offerings.Since then, only a single addnl. metastable beta alloy, Ti-5Al-5V-5Mo-3Cr-0.5Fe, has been commercialized in aerospace, although low volumes of other chemistries have found a place in the biomedical implant market.This article examines the evolution of this important class of materials and the current status in airframe applications.It speculates on challenges for expanding their use.

01 Feb 2013·Metallurgical and Materials Transactions A

Optimization of Blended-Elemental Powder-Based Titanium Alloy Extrusions for Aerospace Applications

Author: Vladimir Moxson ; Ernie M. Crist ; Tony S. Esposito ; Michael B. Campbell ; Sami M. El-Soudani ; Joshua J. Phillips ; Kuang-O. Yu ; Vlad A. Duz ; Fusheng Sun

The process of canless extrusion in ambient environment, using cold isostatic pressed, and vacuum-sintered, direct-consolidated blended-elemental hydrided ADMA titanium powder, mixed with master alloy powder for the Ti-6Al-4V composition, has been successfully demonstrated.However, these initially processed unoptimized powder-based extrusions also exhibited oxygen content of about 3000 ppm, within the ASTM B817 Standard, but exceeding the AMS Specification 4935 maximum limit of 2000 ppm, and with pre-extrusion residual hydrogen within 300-500 ppm resulting in post-extrusion void nucleation aligned with the extrusion direction.Addnl. optimization of extrusion billets during the CIP-and-sintering steps has been successfully demonstrated reducing both oxygen and hydrogen contents to levels at or below the AMS Specification limits for Ti-6Al-4V composition (oxygen content of 2000 ppm maximum, and hydrogen content of 125 ppm maximum).Processing-microstructure-property correlations of the optimized, AMS-4935-Specification-conformant, Ti-6Al-4V blended-elemental powder-based product form exhibited an overall mech. property balance matching that of double-arc-remelted ingot-based extrusions.Property matching was not only in terms of static mech. properties (room-temperature tensile properties, and monotonic fracture toughness K _IC (K _Q) values), but also in terms of dynamic fatigue properties (combined S/N plus da/dN properties), as well as stress-corrosion resistance, as measured in terms of K _ISCC threshold values.

01 Jan 2013·Fatigue of Materials II

High Frequency Vibration Based Fatigue Testing of Developmental Alloys

Author: Casey M. Holycross ; Stephan M. Russ ; Seshacharyulu Tamirisakandala ; Tommy J. George ; Raghavan Srinivasan

Many fatigue test methods have been previously developed to rapidly evaluate fatigue behavior. This increased test speed can come at some expense, since these methods may require non-standard specimen geometry or increased facility and equipment capability. One such method, developed by George et al, involves a base-excited plate specimen driven into a high frequency bending resonant mode. This resonant mode is of sufficient frequency (typically 1200 to 1700 Hertz) to accumulate 107 cycles in a few hours. One of the main limitations of this test method is that fatigue cracking is almost certainly guaranteed to be surface initiated at regions of high stress. This brings into question the validity of the fatigue test results, as compared to more traditional uniaxial, smooth-bar testing, since high stresses are subjecting only a small volume to fatigue damage. This limitation also brings into question the suitability of this method to screen developmental alloys, should their initiation life be governed by subsurface flaws. However, if applicable, the rapid generation of fatigue data using this method would facilitate faster design iterations, identifying more quickly, material and manufacturing process deficiencies. The developmental alloy used in this study was a powder metallurgy boron-modified Ti-6Al-4V, a new alloy currently being considered for gas turbine engine fan blades. Plate specimens were subjected to fully reversed bending fatigue. Results are compared with existing data from commercially available Ti-6Al-4V using both vibration based and more traditional fatigue test methods.

100 Deals associated with RTI International Metals, Inc.

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100 Translational Medicine associated with RTI International Metals, Inc.

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Pipeline

Pipeline Snapshot as of 24 Jan 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

RTI-1092663 ( CB1R )	Abdominal Obesity Metabolic Syndrome More	Preclinical
RTICBM-74 ( CB1R )	Alcoholism More	Preclinical
RTI-113	Cocaine-Related Disorders More	Discontinued
RTI-108	Cocaine-Related Disorders More	Pending
SORI-6238 ( SERT )	Nervous System Diseases More	Pending