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Neoplasms	1

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Small molecule drug	1

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BAX x Bcl-2 x ROS1	1

A series of air-stable dinuclear complexes, [HNEt₃]₂[Ln₂(L)₂((CH₃O)₂PO₂)₄](BPh₄)₄ (L = 2,14-dimethyl-3,6,10,13,19-pentaazabicyclo[13.3.1]nonadeca1(19), 2,13,15,17-pentene, Ln = Dy, 1-Dy; Tb, 2-Tb; Gd, 3-Gd), has been synthesized and characterized using single-crystal X-ray crystallog. and magnetic measurements.The crystal structures disclose that two di-Me phosphate anions act as bridging ligands, linking two Ln(III) ions.Each Ln(III) ion is eight-coordinated by five nitrogen atoms from a pentadentate Schiff based ligand L and three oxygen atoms from three di-Me phosphates, forming a triangular dodecahedral coordination geometry.Direct-current magnetic susceptibility measurements indicate an extremely weak antiferromagnetic exchange between Gd(III) ions in 3-Gd.Complex 1-Dy exhibits slow magnetic relaxation with an effective energy barrier (U_eff) of 13 K under an applied field of 1000 Oe, whereas 2-Tb does not exhibit single-mol. magnet behavior.This work presents a novel strategy for constructing polynuclear single-mol. magnets by using a pentadetate macrocycle as magnetic building blocks integrated with replaceable axial ligands.

01 Jan 2025·Journal of Colloid and Interface Science

Two birds with one stone: Bimetallic ZnCo2S4 polyhedral nanoparticles decorated porous N-doped carbon nanofiber membranes for free-standing flexible anodes and microwave absorption

Article

Author: Zhang, Kaiyin ; Zhao, Tingting ; Cheng, Bingjie ; Guan, Guangguang ; Tong, Siyi ; Xiang, Jun ; Li, Xiaoqiang

Cost-efficient material with an ingenious design is important in the engineering applications of flexible energy storage and electromagnetic (EM) protection. In this study, bimetallic ZnCo₂S₄ (ZCS) polyhedral nanoparticles homogenously embedded in the surface of porous N-doped carbon nanofiber membranes (ZCS@PCNFM) have been fabricated by electrospinning technique combined with carbonization and hydrothermal processes. As a self-assembled electrode for lithium-ion batteries (LIBs), the bimetallic ZCS nanoparticles possess rich redox reactions, good electrical conductivity, and pseudocapacitive properties, while the three-dimensional (3D) multiaperture architecture of the nanofiber film not only shortens the transfer spacing of lithium ions and electrons but also effectively tolerates the volume variation during lithiation and delithiation cycles. Benefiting from the above merits, the ZCS@PCNFM electrode exhibits good cycle performance (662.3 mA h/g at 100 mA/g after 100 cycles), superior rate capacity (401.3 mA h/g at 1 A/g) and an extremely high initial specific capacity of 1152.2 mAh/g at 100 mA/g. Meanwhile, depending on the hierarchical nanostructure and multi-component heterogeneous interface effects constructed by 3D inlaid architecture, the ZCS@PCNFM nanocomposite exhibits fascinating microwave absorption (MA) characteristics with a superhigh reflection loss (RL) of -49.7 dB at a filling content of only 20 wt% and corresponding effective absorption bandwidth (EAB, RL<-10 dB) of 5.2 GHz ranging from 12.8 to 18.0 GHz at 2.2 mm.

01 Jan 2025·Domestic Animal Endocrinology

Impact of quercetin on autophagy and apoptosis induced by a high concentration of CuSO4 in porcine ovarian granulosa cells

Article

Author: Liu, Jiying ; Li, Mengxuan ; Qi, Nannan ; Xing, Wenwen ; Wang, Binbin

Copper is a vital micronutrient necessary for the maintenance of physiological functions. However, excessive amounts can lead to organ damage. Porcine ovarian granulosa cells are damaged by a high concentration of CuSO₄, which can reduce the reproductive capacity of sows. Quercetin has shown remarkable efficacy in mitigating the harmful effects of heavy metals. Therefore, the aim of this study was to investigate the effects of a high concentration of CuSO₄ on autophagy and apoptosis in porcine ovarian granulosa cells and to explore whether quercetin can counteract these toxic effect. Cell morphology, and the mRNA expression levels of autophagy-related genes (LC3-Ⅰ, ATG5, ATG7, ATG12, Beclin1, mTOR, LC3-Ⅱ and P62) were significantly changed upon treatment with 200 and 400 µM CuSO₄. Treatment with 200 µM CuSO₄ increased expression of P62 protein (P<0.05), promoted LC3-Ⅰ to LC3-Ⅱ conversion (P<0.05), and reduced PINK1 protein expression and the ATP content (P<0.05). In addition, expression of Caspase3 protein was increased and TUNEL staining indicated that the number of apoptotic cells was increased. However, co-treatment with 10 µM quercetin significantly decreased expression of P62 and conversion of LC3-Ⅰ to LC3-Ⅱ. Furthermore, flow cytometric analysis revealed that addition of 10 µM quercetin significantly reduced apoptosis induced by a high concentration of CuSO₄. In summary, the results indicate that a high concentration of CuSO₄ can trigger mitochondrial and autophagy dysfunction, activate mitochondrial apoptosis pathway, and exert cytotoxic effects. Quercetin can mitigate autophagy dysfunction, enhance autophagic processes, and alleviate apoptosis.

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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