Determining Whether Mass Campaigns With Fractional Dose PCV10 Would Accelerate Herd Protection Against Pneumococcal Transmission in Sub-Saharan Africa

The aim of this study is to assess the impact of a mass campaign with a single, fractional dose of Pneumosil®, a PCV10, on VT carriage. A 20% fractional dose (1/5th) will be used as a practical formulation to prepare and administer. This study will assess whether the impact of a single fractional dose mass campaign on carriage is non-inferior to a single full dose mass campaign in a cluster randomized trial in a low coverage setting in Niger. The results would provide evidence of the population-level direct and indirect impact of fractional dose in older children which will be completed by mathematical modelling, to inform the policy debate regarding PCV dosing schedules in different contexts. This trial and the modelling exercises that follow, would allow for larger scale evaluation of fractional dose PCV strategies in multiple contexts.

Start Date30 Dec 2021

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Universite Abdou Moumouni de Niamey

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100 Clinical Results associated with Universite Abdou Moumouni de Niamey

0 Patents (Medical) associated with Universite Abdou Moumouni de Niamey

1,194

Literatures (Medical) associated with Universite Abdou Moumouni de Niamey

01 May 2025·World Neurosurgery

Anterior and Anterolateral Approaches to the Lumbar Spine in a Developing Country: A Series of 28 Cases

Article

Author: Kelani, Aminath ; Sawa Nouga, Brice Audrey ; Late Dzidoula, Lawson ; Haboubacar Chaibou, Sode ; Agada Kpègnon, Nicaise ; Assoumane Issa, Ibrahim ; Bankole, Nourou Dine Adeniran

BACKGROUNDThe frequency of lumbar trauma in surgical emergencies at Niamey National Hospital, Niamey, Niger, is enormous. Injuries are most often amenable to an anterior or anterolateral approach, but because of a lack of expertise in surgical technique, they are usually operated on using a posterior approach. We aim to evaluate the management of lumbar spine fractures, including hinge fractures, using an anterior or anterolateral approach in a precarious context.METHODSRetrospective and prospective observational descriptive study over 34 months including 28 patients who benefited from an anterior or anterolateral approach. The osteosynthesis material used was a bone graft fixed by a stainless steel plate and screws. The mean follow-up was 3 months.RESULTSAnterior and anterolateral approaches had a hospital incidence of 3.16%. At follow-up, there was no neurologic deterioration, with an improvement in 75% of patients, despite deterioration of locoregional kyphosis in 76.92% of cases. One patient died in the immediate postoperative period and 1 died during medium-term follow-up.CONCLUSIONSThe anterior approach to the spine is a therapeutic arsenal that needs to be mastered. Efforts are still required to acquire suitable equipment for correct sagittal balance.

01 Mar 2025·Annals of Medicine & Surgery

Epidemiology, clinic, therapeutic, and outcome of pelvic organ prolapse: a retrospective single-center cohort study

Article

Author: Harouna Salifou, Jamila ; Nayama, Madi ; Amadou Issa, Abdou ; Oumara, Maina ; Lankonde Salifou, Zelika ; Nouhou, Hassan ; Abdoul-Wahab Mahamadou, Moumouni ; Oumarou Garba, Souleymane ; Soumana Diaouga, Hamidou ; Abdoulaye, Maman Bachir

Introduction:Pelvic organ prolapse (POP) is a major public health problem. This study aims to determine the incidence, sociodemographic profile of patients, the management and outcomes of POP in a maternity hospital with limited resources in Niger.Methodology:This was an eight-year retrospective cohort study involving the analysis of medical records from patients who underwent management of POP between 1 January 2015 and 31 December 2022 in our department. The epidemiological data, treatment, and outcomes of POP were collated and subjected to analysis.Results:During the study period, 358 cases of POP were recorded out of a total of 12 536 patients treated in the department, representing a frequency of 2.8%. The mean age of the patients was 46.14 years (range: 17–90 years). The patients were identified as married (307 cases, 85.75%), unemployed (353 cases, 98.6%) and not attending school (332 cases, 92.74%). The largest number of cases were observed in large multiparous women (60.05%, 215 patients). The average parity was 6.5 children. The vast majority of patients (269 cases, 75.14%) lived in rural areas. The most frequent motif for consultation was the sensation of mass in the vagina (146 cases, 40.78%) and vulvar swelling (138 cases, 38.55%). The most frequent genital prolapses type was middle, made of the hysterocele essentially (150 cases, 41.90%). The stage III of genital prolapses was the most frequent in 76.51% (274 cases). All patients underwent surgical treatment (100%), and the vaginal access was most used in 57.55% (206 cases) of cases. Conservative treatment was performed in the majority of patients (197 cases, 55.02%). The intraoperative complications were vesical lesions (0.56%, two cases) and ureteral and vascular lesion (0.28%, one case).Conclusion:POP is a common occurrence in our region. Surgical treatment is the most practiced and hysterectomy by vaginal surgical approach is the most practiced.

13 Feb 2025·Nature

Regional and institutional trends in assessment for academic promotion

Article

Author: Germo Nzweundji, J ; Dominik, M ; Saktiawati, A M I ; Siciliano, V ; Morales-Salgado, V S ; Režek Jambrak, A ; Cloete, K J ; Balboa, L ; Backes, M ; Palomo, I ; Lopez-Verges, S ; Egamberdieva, D ; Hussein, H ; Chong, K K ; Dela Cruz, T E ; Enany, S ; Hernández-Mondragón, A C ; Flores Bueso, Y ; Vermeir, K ; Elagroudy, S ; D'Ippoliti, C ; Mondello, S ; Kumar, P ; Lim, B H ; Kimengsi, J N ; Molnar, A ; Simonyan, A ; Narita, V ; Sidi Zakari, I

AbstractThe assessment of research performance is widely seen as a vital tool in upholding the highest standards of quality, with selection and competition believed to drive progress. Academic institutions need to take critical decisions on hiring and promotion, while facing external pressure by also being subject to research assessment1–4. Here we present an outlook on research assessment for career progression with specific focus on promotion to full professorship, based on 314 policies from 190 academic institutions and 218 policies from 58 government agencies, covering 32 countries in the Global North and 89 countries in the Global South. We investigated how frequently various promotion criteria are mentioned and carried out a statistical analysis to infer commonalities and differences across policies. Although quantitative methods of assessment remain popular, in agreement with what is found in more geographically restricted studies5–9, they are not omnipresent. We find differences between the Global North and the Global South as well as between institutional and national policies, but less so between disciplines. A preference for bibliometric indicators is more marked in upper-middle-income countries. Although we see some variation, many promotion policies are based on the assumption of specific career paths that become normative rather than embracing diversity. In turn, this restricts opportunities for researchers. These results challenge current practice and have strategic implications for researchers, research managers and national governments.

100 Deals associated with Universite Abdou Moumouni de Niamey

100 Translational Medicine associated with Universite Abdou Moumouni de Niamey

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