[Translation] A randomized, double-blind, placebo-controlled, dose-escalation Phase I clinical study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single subcutaneous injection of ART101 injection in healthy adult subjects
评价在健康成年受试者中单次皮下注射ART101的免疫原性特征; 评价在健康成年受试者中单次皮下注射ART101对肾素-血管紧张素-醛固酮系统(RAAS)的探索性生物标志物的影响; 评估在健康成年受试者中单次皮下注射ART101的暴露-效应关系; 评估在健康成年受试者中单次皮下注射ART101的潜在代谢产物特征
[Translation] To evaluate the immunogenicity profile of a single subcutaneous injection of ART101 in healthy adult subjects; To evaluate the effect of a single subcutaneous injection of ART101 on exploratory biomarkers of the renin-angiotensin-aldosterone system (RAAS) in healthy adult subjects; To evaluate the exposure-effect relationship of a single subcutaneous injection of ART101 in healthy adult subjects; To evaluate the potential metabolite profile of a single subcutaneous injection of ART101 in healthy adult subjects