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Last update 08 May 2025

Army Hospital

Hospital|Afghanistan

Last update 08 May 2025

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Deal

Translational Medicine

Overview

Clinical Trials associated with Army Hospital

CTRI/2023/03/050776

/ CompletedPhase 3IIT

Randomised controlled trial to determine the efficacy of darbepoetin in improving haemoglobin in patients of rheumatoid arthritis with anaemia of chronic disease

Start Date31 Mar 2023

Sponsor / Collaborator

Army Hospital

100 Clinical Results associated with Army Hospital

0 Patents (Medical) associated with Army Hospital

1,183

Literatures (Medical) associated with Army Hospital

04 May 2025·Journal of Asthma

A decision tree analysis to evaluate the optimal approach to screen allergic bronchopulmonary aspergillosis in asthmatic patients

Article

Author: Rudramurthy, Shivaprakash Mandya ; Prasad, Kuruswamy Thurai ; Agarwal, Ritesh ; Sehgal, Inderpaul Singh ; Chakrabarti, Arunaloke ; Dhooria, Sahajal ; Soundappan, Kathirvel ; Aggarwal, Ashutosh Nath ; Garg, Mandeep ; Muthu, Valliappan ; Saxena, Puneet

BACKGROUNDVarious methods are available to screen for allergic bronchopulmonary aspergillosis (ABPA) in asthma, but their comparative performance remains uncertain.OBJECTIVESTo identify the optimal screening algorithm for ABPA in asthmatic patients and evaluate the crude cost of various diagnostic approaches.METHODSWe performed a post hoc analysis of prospectively collected data from consecutive adult asthmatic patients evaluated for ABPA. The diagnosis was based on the revised International Society for Human and Animal Mycology ABPA Working Group criteria. Initial evaluations included measurements of serum Aspergillus fumigatus-IgE (≥0.35 kUA/L), serum total IgE (≥500 IU/mL), serum A. fumigatus-IgG (≥27 mgA/L), blood eosinophil count (BEC ≥500 cells/μL), and chest CT findings. A decision tree was manually constructed using recursive partitioning to identify the most effective diagnostic pathway.RESULTSAmong 543 adult asthmatics, 106 were diagnosed with ABPA. Serum A. fumigatus-IgE was positive in 221 (40.7%) patients, while serum total IgE was elevated (≥500 IU/mL) in 300 (55.3%) patients. The serum total IgE-based approach required 196 additional tests during screening, compared to 115 in the A. fumigatus-IgE method. The BEC-based strategy missed 28 cases of ABPA. Although the CT-directed protocol had the fewest false positives, it required 437 additional screening radiographic procedures and missed eight ABPA cases. The A. fumigatus-IgE pathway emerged as the most cost-effective, whereas imaging-based strategies were the most expensive.CONCLUSIONSSerum A. fumigatus-IgE is the optimal screening test for ABPA in asthma. It minimizes unnecessary testing while maintaining high diagnostic accuracy, making it a preferable approach in clinical practice.

01 Apr 2025·Injury

Lessons learned: The thematic analysis of eight countries with mature trauma systems

Article

Author: Caminsky, Natasha ; Cioffi, Stefano ; Ratnayake, Amila ; Bala, Miklosh ; Wong, Evan ; Cole, Elaine ; Fitzgerald, Mark ; Chiara, Osvaldo ; Levi, Amelia ; Scalea, Thomas ; Rivkind, Avraham I ; Civil, Ian ; James, Arthur ; Kushner, Adam L ; Gupta, Shailvi ; Balasubramaniam, Sunder

INTRODUCTIONAs the ravages of war, road traffic crashes, and interpersonal violence have led society to view injury as a preventable illness, the delivery of trauma care has shifted from the standalone hospital to system-based care. A trauma system is an organized, coordinated, integrated effort that delivers care from the prehospital setting to the facility, and then to rehabilitation, to reduce morbidity and mortality of the injured patient. However, many countries still lack this systematic care. Recognizing this discrepancy, we conducted what appears to be the first multinational, collaborative study of mature trauma systems in order to identify their successes and challenges, so that we may close this gap in care.METHODSFrom January 2022-January 2023, trauma system leaders in Australia, Canada, France, Israel, Italy, New Zealand, the United Kingdom, and the United States of America answered a semi-structured questionnaire. Each expert detailed their system's context for creation, delineated their successes and challenges, and described their plans for future development. From this data we extracted key themes shared by all eight systems.RESULTSOur results revealed that these eight mature trauma systems are encompassed by two main processes, which we titled 'development' and 'maturation'. We found that the developmental process relies on a sentinel paper inciting political leadership to build the system. The system then contains six essential elements: governance, trauma network, pre-hospital care, facility-based care, trauma registry/quality improvement, and rehabilitation. The maturation process is the course of operationalizing the system once it is established to produce the intended result. This consists of connectivity and coordination, supporting key stakeholders, and continually subjecting the system to review for improvement.CONCLUSIONThis innovative study describes eight distinct mature trauma systems and identifies commonalities between them. The lessons learned from these eight systems should be used both by countries with an existing trauma system to aid in maturation, and by developing nations looking to construct a trauma system, so that the disparities in trauma care delivery may start to dissipate.

01 Mar 2025·Indian Journal of Otolaryngology and Head & Neck Surgery

Evaluation of Scar Cosmesis and Quality of Life After Thyroid Surgery: A Retrospective Study

Article

Author: Dwivedi, Surjeet ; Dutta, Angshuman ; Varshaney, Amar ; Majumdar, Sumantra Shekher ; Sharma, Mandeep ; Kumar, Sanjay ; Dwivedi, Sabita ; Dinker, Yateendra ; Saxena, Vishal

IntroductionThyroid surgery is a common procedure for managing benign and malignant conditions. While the primary focus is on treating the underlying pathology, visible neck scars can significantly impact patients' self-esteem and quality of life (QoL). A comprehensive assessment of scar cosmesis alongside functional outcomes is essential. Despite the availability of tools such as the Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS), studies combining subjective and objective scar assessments with thyroid-specific and general QoL measures remain limited.MethodologyThis retrospective study evaluated scar cosmesis and QoL in 100 thyroidectomy patients treated between January 2021 and December 2023. Subjective satisfaction was measured using the Visual Analog Scale (VAS), and objective assessments were performed using VSS and POSAS. QoL was assessed using validated instruments, ThyPRO and SF-36, to capture thyroid-specific and general QoL domains. Statistical analyses included t-tests, Pearson correlation, and multivariate regression.ResultsThe mean VAS score was 7.8, with 85% of patients reporting satisfaction with their scars. Objective evaluations yielded mean VSS and POSAS scores of 5.2 and 6.8, respectively. Younger patients (VAS = 8.2 for ≤ 50 years) and females (VAS = 8.0) reported higher satisfaction with scar outcomes. QoL improved significantly, with physical functioning increasing from 65.3 to 76.8 (p < 0.01) and emotional well-being from 61.2 to 70.1 (p < 0.05). Significant correlations were observed between scar cosmesis scores and QoL domains, such as physical functioning (r = 0.42). Sensory changes, including numbness around the scar area, were reported in 12% of patients.ConclusionIntegrating subjective and objective measures, including ThyPRO and SF-36, provides a complete evaluation of scar cosmesis and QoL outcomes after thyroidectomy. Key predictors of higher satisfaction included younger age, female gender, and superior scar quality. These findings highlight the importance of addressing both aesthetic and functional outcomes in thyroid surgery to enhance patient satisfaction and QoL.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12070-025-05368-w.

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100 Translational Medicine associated with Army Hospital

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