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Overview

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Infectious Diseases

Other Diseases

Small molecule drug

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Infectious Diseases	3

Top 5 Drug Type	Count

Small molecule drug	4

Top 5 Target	Count

DNA	2
TLR7(Toll like receptor 7)	1

The national biofuel policy of the Indian government support to put a great emphasis on the synthesis of biodiesel from the nonedible feedstock.A potential option in this regard is Neem oil which is found in abundance in India (∼1,00,000 tonnes).The major hindrance to the commercialization of biodiesel is its shelf life due to poor oxidation and stability characteristics.The current work investigates the oxidation stability of Neem biodiesel as per EU standard (EN14214) using the Rancimat apparatusThe oxidation stability of 12.3 h without doping any chem. antioxidant in the synthesized Neem biodiesel makes it highly suitable for com. acceptance.The impact of pyrogallol (PY) antioxidant was also investigated on the shelf life of Neem biodiesel build on response surface methodol. (RSM) in accordance with Box-Behnken Design (BBD).Moreover, the execution and excretion characteristic of the Neem biodiesel blends: B15, B25, B35, and B45 are investigated on direct injection automotive compression ignition engine.Based on this broad exptl. investigation B15 blend can be used as a fuel to power the existing automotive compression ignition engine with no compromise in the execution and excretion characteristics of the engine.From the anal. of the data of life-cycle assessment of the Neem biodiesel, it was found that it possesses the global warming potential of 45.72gCO₂-eq Functional Unit^-1 which is six times lesser than mineral diesel.Moreover, the Neem plantation has a carbon dioxide isolation potential of around 10 t ha^-1 year ^-1.All these factors make the Neem Biodiesel highly suitable for blending with mineral diesel to power the existing compression ignition engines.

01 Oct 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Lipoic acid assisted microwave based synthesis of Au-Ag nanoclusters with tunable fluorescence for antimicrobial and bioimaging applications

Article

Author: Sharma, Rohit K ; Sharma, Deepika ; Sharma, Rohit ; Sharma, Pankaj ; Wangoo, Nishima

This study reports on the pioneering synthesis and application of monometallic lipoic acid (LA) stabilized gold nanoclusters (LA@AuNCs) and bimetallic gold-silver nanoclusters (LA@Au-AgNCs) fabricated via a novel microwave-assisted method. The synthesis process unveils a significant augmentation in the quantum yield of LA@AuAgNCs up to 7.9-fold compared to their monometallic counterparts (LA@Au NCs), showcasing the efficacy of the novel microwave-assisted fabrication methodology. The rapid synthesis facilitated by microwave heating not only ensures efficiency but also contributes to superior optical properties. Additionally, the strategic modulation of exogenous parameters, such as thermal conditions and ionic metal concentrations, was leveraged to meticulously engineer the nanocluster surface characteristics, facilitating the procurement of tunable photoluminescent emission spectra spanning from 650 to 800 nm. The applicability of the synthesized metallic nanoclusters has been rigorously evaluated, demonstrating their efficacy as a dual-functional therapeutic agent. Primarily, their antimicrobial properties are pronounced against both Gram-positive and Gram-negative bacterial strains, attributed to the ultrasmall dimensions of the synthesized nanoclusters. Also, these intrinsically fluorescent metallic nanoclusters were employed as advanced bioimaging probes for the precise labelling and visualization of bacterial cells.

01 Aug 2025·Advances in Colloid and Interface Science

Unravelling the therapeutic properties of aptamer-modified exosome nanocomposite

Review

Author: Priyadarshi, Nitesh ; Rana, Niket ; Kumar, Sandeep ; Singhal, Nitin Kumar ; Bajaj, Geetika ; Makkar, Simran

Exosomes are naturally occurring nanocarriers derived from various cells. In recent years, they have attained significant attention for their potential in precise drug delivery and therapeutic applications. Exosomes exhibit several advantages, remarkably improved stability, bioavailability, and delivery efficiency, which are further augmented by integration with nanomaterials. Functionalizing the aptamer and nanomaterial on the exosomal surface significantly improves the binding affinity and specificity. Here in this review, we examine the synergistic therapeutic effect of exosome-nanomaterial-aptamer conjugate with particular attention to their uses in cancer therapy, bone fracture regeneration, wound healing, etc. Recent advances in the field demonstrated that the amalgamation of different nanomaterials, aptamers, and exosomes has proven to be a transformative approach in the field of therapeutics. Here in the nanocomposite, the aptamer is exclusively used as a recognition molecule to provide specificity to the target cells. Exosomes serve as biocompatible nanocarriers, and different nanomaterials (AuNPs, AuNRs, SiNPs, Graphene, etc.) complement the therapeutic efficiency by PTT/PDT/ROS generation/SO generation, etc. Briefly, the above-mentioned nanocomposite serves as the perfect therapeutic agent by utilizing the exosome's biocompatibility, aptamer's high affinity and nanomaterial's multifunctionality. Furthermore, the challenges and limitations of this nanocomposite have been discussed, along with its prospects in clinical practices.

100 Deals associated with Punjabi University

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100 Translational Medicine associated with Punjabi University

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Pipeline

Pipeline Snapshot as of 08 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

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3

Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Bis-naphthalimides-5d ( DNA )	Bacterial Infections More	Preclinical
TLR7 agonists(Punjabi University) ( TLR7 )	Drug adjuvant More	Preclinical
Bis-naphthalimides-5o ( DNA )	Bacterial Infections More	Preclinical
Bile Acid Oligomers(Panjab University)	Staphylococcus Aureus Infections More	Discovery