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Infectious Diseases

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A glimpse into the focused therapeutic areas

Technology Platform

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Disease Domain	Count

Infectious Diseases	3

Top 5 Drug Type	Count

Small molecule drug	4

Top 5 Target	Count

DNA	2
TLR7(Toll like receptor 7)	1

Imidazo based heterocyclic derivatives are considered as privileged scaffolds due to their presence in various pharmacologically active compounds and in marketed formulations. The present study reports toxicological evaluation of three imidazo based heterocyclic derivatives which are currently being investigated for their potential anticancer activity. Compounds IG-01-007, IG-01-008, and IG-01-009 were assessed for cytotoxicity, hemolysis, and DNA fragmentation activity. Acute oral toxicity studies were performed at doses of 300 mg/kg and 1000 mg/kg according to OECD guidelines, in both male and female Wistar rats. All test compounds at a concentration of 50 µM resulted in DNA fragmentation suggesting notable impact on DNA integrity. The in-vivo acute toxicity study indicated significant toxicity at doses of ≥ 1000 mg/kg, particularly for compounds IG-01-008 and IG-01-009, which caused hepatic damage and cholestasis in liver tissues. These results collectively suggest that imidazo based heterocyclic derivatives used in the present study exhibit cytotoxic potential.

01 Apr 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

A fluorometric sensor for Tin(II) detection using Azomethine-Triazole organosilane: Turn-off mechanism, antioxidant activity and molecular docking insights

Article

Author: Kaur, Harshbir ; Singh, K N ; Dalal, Anurag ; Puspa ; Rani, Bhavana ; Singh, Gurjaspreet ; Malik, Pooja

The need for metal ion sensors is increasing daily due to the harmful impact of metal ions on human health, the environment, and the aquatic ecosystem. The present study highlights synthesizing an azomethine functionalized triazole allied organosilane (5a) probe as a turn-off fluorometric sensor for Sn(II) recognition with high anti-interference even when the other metal ions are present. The probe (5a) offers a detection limit of up to 6.4 × 10^-10 M which is much lesser than the WHO acceptable limit (2 µg/L) of Sn(II) in drinking water. The fluorometric and absorbance-based UV-visible spectroscopy method is used for this analysis due to their ease of sample preparation, low cost, quick analysis, high sensitivity and selectivity, and less time-consuming nature. The real sample analysis (recovery % more than 97) results of the probe (5a) prove that it can detect the Sn(II) in different water samples increasing its practical applicability. The biological activities of the presently synthesized compounds were also studied providing valuable insights into their biological potential. Probe (5a) showed effective antioxidant potential. Bacterial domain inhibition by Probe (5a) was also analyzed using molecular docking, which showed good inhibitory activity by the probe (5a).

01 Apr 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Turn-off fluorescent magnetic Mn-ZnS molecularly imprinted probe for the detection of chlorpyrifos in vegetable samples

Article

Author: Bhogal, Shikha ; Malik, Ashok Kumar ; Kumar, Sandeep ; Aulakh, Jatinder Singh ; Kaur, Gurpreet

A sensitive and efficient fluorescent sensor based on a magnetic manganese-doped zinc sulfide molecularly imprinted probe (Fe₃O₄/Mn-ZnS/MIP) was successfully developed for the detection of chlorpyrifos (CPF). The probe combined the advantages of magnetic separation, the fluorescence properties of Mn-ZnS, and the exceptional molecule recognition capabilities of molecularly imprinted polymers. The developed sensor exhibits selective binding to CPF, resulting in a quenching of fluorescence intensity of Fe₃O₄/Mn-ZnS/MIP by a photo-induced electron transfer mechanism. The sensor demonstrated a detection limit of 0.41 ng/mL within a linear range of 1-50 ng/mL. Further, the probe was effectively utilized to analyze vegetable samples (cabbage, and cauliflower), yielding recoveries of 97.10-102.15 %. The objective of this research is to contribute to the development of a highly effective fluorescence sensing system capable of detecting several dangerous substances, including chlorpyrifos.

100 Deals associated with Punjabi University

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100 Translational Medicine associated with Punjabi University

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Pipeline

Pipeline Snapshot as of 03 Apr 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Discovery

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Preclinical

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

TLR7 agonists(Punjabi University) ( TLR7 )	Drug adjuvant More	Preclinical
Bis-naphthalimides-5d ( DNA )	Bacterial Infections More	Preclinical
Bis-naphthalimides-5o ( DNA )	Bacterial Infections More	Preclinical
Bile Acid Oligomers(Panjab University)	Staphylococcus Aureus Infections More	Discovery