A common structural feature of polyketide natural products is the presence of contiguous stereotetrad arrays; which are very challenging targets to synthesize; stereocontrol, in particular, is not trivial. We have successfully optimized the synthesis of the stereotetrad building blocks on hundreds of grams scales. Challenges facing the development of polyketide natural products are scarcity, lack of a sustainable supply, and their highly complex structures that impede chem. synthesis. At Akanocure, we found the solution to the building blocks supply problem through our patented Chiral Carbon Catalog synthesis platform (CCC) without the utilization of any chiral auxilliaries. Briefly, Cycloheptadienyl sulfone is converted on a practical synthetic scale to syn-, and anti-cycloheptadienyllsulfone stereodiads via improved procedures in a single process (no chromatog., crystallization or distillation required). These stereodiads are then transformed to stereotetrads that are key arrays in multiple polyketide natural products. Oxidative cleavages of these tetrads efficiently deliver complex termini-differentiated steroarrays ready for couplings. We have successfully applied our protocol towards the total synthesis of aplyronine A (ApA); an exceptionally scarce marine macrolide of unique mechanism and potent anticancer activity.